2009
Role of Clopidogrel Loading Dose in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Angioplasty Results From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial
Dangas G, Mehran R, Guagliumi G, Caixeta A, Witzenbichler B, Aoki J, Peruga J, Brodie B, Dudek D, Kornowski R, Rabbani L, Parise H, Stone G, Investigators H. Role of Clopidogrel Loading Dose in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Angioplasty Results From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial. Journal Of The American College Of Cardiology 2009, 54: 1438-1446. PMID: 19796737, DOI: 10.1016/j.jacc.2009.06.021.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngioplasty, BalloonAnticoagulantsClopidogrelConfidence IntervalsFemaleHirudinsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPeptide FragmentsPlatelet Aggregation InhibitorsProportional Hazards ModelsRecombinant ProteinsTiclopidineTreatment OutcomeConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionPrimary PCIGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsClopidogrel loading doseHORIZONS-AMI trialElevation myocardial infarctionLoading doseMyocardial infarctionAdverse cardiac event ratesMajor adverse cardiac eventsEvent ratesCardiac event rateLoading dose groupProbable stent thrombosisAdverse cardiac eventsAdverse event ratesPercutaneous coronary interventionHigher bleeding rateBivalirudin monotherapyPrimary angioplastyAnticoagulation regimensCardiac eventsCoronary intervention
2005
Metabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus
Wilson P, D’Agostino R, Parise H, Sullivan L, Meigs J. Metabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus. Circulation 2005, 112: 3066-3072. PMID: 16275870, DOI: 10.1161/circulationaha.105.539528.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseMetabolic syndromeCardiovascular diseaseRelative riskAge-adjusted relative riskType 2 diabetes mellitusPopulation attributable risk estimatesNew cardiovascular diseaseMetabolic syndrome traitsMiddle-aged adultsDiabetes mellitusIncident casesHeart diseaseNew T2DMT2DMType 2SyndromeEvent ratesRisk estimatesDiseaseSyndrome traitsMellitusWomenMenRisk