2000
HNF3β and GATA-4 transactivate the liver-enriched homeobox gene, Hex
Denson L, McClure M, Bogue C, Karpen S, Jacobs H. HNF3β and GATA-4 transactivate the liver-enriched homeobox gene, Hex. Gene 2000, 246: 311-320. PMID: 10767553, DOI: 10.1016/s0378-1119(00)00082-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCOS CellsDNADNA-Binding ProteinsGATA4 Transcription FactorGenes, HomeoboxHepatocyte Nuclear Factor 3-betaHomeodomain ProteinsHumansLiverLuciferasesMaleMiceMolecular Sequence DataNuclear ProteinsPlasmidsPromoter Regions, GeneticProtein BindingRatsRats, Sprague-DawleyRecombinant Fusion ProteinsSequence Analysis, DNASp1 Transcription FactorSp3 Transcription FactorTranscription FactorsTranscriptional ActivationTransfectionTumor Cells, Cultured
1998
Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats
Jacobs H, Bogue C, Pinter E, Wilson C, Warshaw J, Gross I. Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats. Pediatric Research 1998, 44: 99-104. PMID: 9667378, DOI: 10.1203/00006450-199807000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButyratesButyric AcidDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGestational AgeHistone Deacetylase InhibitorsLungOrgan Culture TechniquesPregnancyPregnancy in DiabeticsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsLung developmentLung explantsSurfactant apoproteinExperimental animalsLung mRNA levelsElevated levelsEffect of diabetesFetal rat lung explantsLungs of fetusesRat lung explantsEffect of butyrateAntenatal exposureMaternal diabetesMetabolic abnormalitiesStreptozotocin treatmentLower incidenceNormal ratsDiabetesDexamethasoneLevel of expressionRatsTreatment of explantsSodium butyrateMRNA levelsAlters expression
1994
Identification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression
Bogue CW, Gross I, Vasavada H, Dynia DW, Wilson CM, Jacobs HC. Identification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression. American Journal Of Physiology 1994, 266: l448-l454. PMID: 7909996, DOI: 10.1152/ajplung.1994.266.4.l448.Peer-Reviewed Original ResearchConceptsGestational ageReverse transcription-polymerase chain reactionNewborn mouse lungRat lung explantsMouse lungRetinoic acidMRNA levelsLung explantsRat lungFetal rat lung explantsEffects of RATranscription-polymerase chain reactionM retinoic acidTime-dependent increaseNewborn lungRA treatmentFetal miceLungRodent lungsSignificant doseHigher mRNA levelsFetal tissuesDivergent homeobox gene HexGene expressionPattern of expressionHeat shock does not induce tolerance to hyperoxia
Strand C, Warshaw J, Snow K, Jacobs H. Heat shock does not induce tolerance to hyperoxia. Lung 1994, 172: 79-89. PMID: 8114515, DOI: 10.1007/bf00185079.Peer-Reviewed Original ResearchConceptsHeat shock proteinsHyperoxic exposureHyperoxic stressOxidant stressLeast partial toleranceShock proteinsComparison of lungInduced toleranceLeast partial protectionInduction of HSP70Diphenyl tetrazolium bromideClinical situationsPartial toleranceLung fibroblastsPartial protectionMinimal inductionTetrazolium bromideOverlap of mechanismsHSP70 mRNAInductionLive animalsAbility of cellsLevel of protectionExposureAnimals