2000
Immunocytochemical Characterization of Murine Hex, a Homeobox-Containing Protein
Ghosh B, Ganea G, Denson L, Iannucci R, Jacobs H, Bogue C. Immunocytochemical Characterization of Murine Hex, a Homeobox-Containing Protein. Pediatric Research 2000, 48: 634-638. PMID: 11044484, DOI: 10.1203/00006450-200011000-00014.Peer-Reviewed Original ResearchConceptsMouse embryosGlutathione S-transferase fusion proteinS-transferase fusion proteinDivergent homeobox genesWhole mouse embryosTerminal amino acidsHepatic specificationHex proteinHomeobox genesMouse developmentDefinitive endodermBlood islandsNuclear localizationEndodermal cellsFusion proteinHex expressionProtein presentCultured cellsAmino acidsWhole mountsConfocal microscopyHepatic diverticulumProteinEmbryosWestern blot
1990
Corticosteroids and Intratracheal Surfactant Both Alter the Distribution between the Airways and Lung Tissue of Intratracheally Administered Radiolabeled Phosphatidylcholine in the Preterm Rabbit
Fiascone J, Mercurio M, Lima D, Jacobs H. Corticosteroids and Intratracheal Surfactant Both Alter the Distribution between the Airways and Lung Tissue of Intratracheally Administered Radiolabeled Phosphatidylcholine in the Preterm Rabbit. Experimental Lung Research 1990, 16: 311-321. PMID: 2394199, DOI: 10.3109/01902149009108847.Peer-Reviewed Original ResearchConceptsIntratracheal surfactantLung tissueAlveolar spaceCorticosteroid exposureMechanical ventilationRinger's lactateAntenatal corticosteroid exposurePrenatal corticosteroid exposurePreterm rabbitsLung clearanceIntratracheal injectionAlveolar lavageDay 25FetusesClearanceVentilationAirwayRadiolabel distributionLactateTissueRabbitsExposureRadiolabelCorticosteroidsLavage
1989
Antenatal steroids, postnatal surfactant, and pulmonary function in premature rabbits
Gladstone I, Mercurio M, Devenny S, Jacobs H. Antenatal steroids, postnatal surfactant, and pulmonary function in premature rabbits. Journal Of Applied Physiology 1989, 67: 1377-1382. PMID: 2793738, DOI: 10.1152/jappl.1989.67.4.1377.Peer-Reviewed Original ResearchConceptsDynamic compliancePulmonary functionLung resistanceTotal lung conductanceTotal lung resistancePulmonary function testsRespiratory distress syndromeConsistent tidal volumeAntenatal corticosteroidsAntenatal steroidsIntramuscular betamethasonePostnatal surfactantDistress syndromeFunction testsCombination therapyPulmonary mechanicsExpiratory timePremature rabbitsTidal volumeStatic complianceLung conductanceFirst breathDay 27Day 25SteroidsSurface tension and pulmonary compliance in premature rabbits
Mercurio M, Fiascone J, Lima D, Jacobs H. Surface tension and pulmonary compliance in premature rabbits. Journal Of Applied Physiology 1989, 66: 2039-2044. PMID: 2745272, DOI: 10.1152/jappl.1989.66.5.2039.Peer-Reviewed Original Research
1988
Reutilization of surfactant phosphatidylglycerol and lysophosphatidylcholine by adult rabbits
Jacobs H, Lima D, Fiascone J, Mercurio M. Reutilization of surfactant phosphatidylglycerol and lysophosphatidylcholine by adult rabbits. Biochimica Et Biophysica Acta 1988, 962: 227-233. PMID: 3167080, DOI: 10.1016/0005-2760(88)90164-6.Peer-Reviewed Original Research
1987
Betamethasone Increases Pulmonary Compliance in Part by Surfactant-Independent Mechanisms in Preterm Rabbits
Fiascone J, Jacobs H, Moya F, Mercurio M, Lima D. Betamethasone Increases Pulmonary Compliance in Part by Surfactant-Independent Mechanisms in Preterm Rabbits. Pediatric Research 1987, 22: 730-735. PMID: 3431959, DOI: 10.1203/00006450-198712000-00024.Peer-Reviewed Original ResearchConceptsAntenatal corticosteroidsIntratracheal surfactantPulmonary complianceDynamic complianceAlveolar surfactant contentHigher dynamic complianceAntenatal exposurePreterm rabbitsPreterm animalsSingle therapyAlveolar lavageTidal volumeCorticosteroidsFirst breathFetusesDay 25Compliance studiesVentilationRabbitsComplianceCompliance measurementsLavageGestationBetamethasoneTherapy
1985
Reutilization of surfactant phosphatidylcholine in adult rabbits
Jacobs H, Ikegami M, Jobe A, Berry D, Jones S. Reutilization of surfactant phosphatidylcholine in adult rabbits. Biochimica Et Biophysica Acta 1985, 837: 77-84. PMID: 3840389, DOI: 10.1016/0005-2760(85)90087-6.Peer-Reviewed Original ResearchLeakage of protein in the immature rabbit lung; effect of surfactant replacement
Robertson B, Berry D, Curstedt T, Grossmann G, Machiko I, Jacobs H, Jobe A, Jones S. Leakage of protein in the immature rabbit lung; effect of surfactant replacement. Respiratory Physiology & Neurobiology 1985, 61: 265-276. PMID: 3840603, DOI: 10.1016/0034-5687(85)90070-2.Peer-Reviewed Original ResearchConceptsSurfactant-treated animalsControl animalsSurfactant replacementAlveolar wash samplesOnset of ventilationAverage tidal volumeImmature rabbit lungsImmature newborn rabbitsInsufflation pressureImmature lungSurfactant inhibitorsTidal volumeRabbit lungsAlveolar compartmentNewborn rabbitsDay 27Wash samplesPrevious treatmentLeakage of proteinsReutilization of phosphatidylglycerol and phosphatidylethanolamine by the pulmonary surfactant system in 3-day-old rabbits
Jacobs H, Jobe A, Ikegami M, Jones S. Reutilization of phosphatidylglycerol and phosphatidylethanolamine by the pulmonary surfactant system in 3-day-old rabbits. Biochimica Et Biophysica Acta 1985, 834: 172-179. PMID: 3838906, DOI: 10.1016/0005-2760(85)90153-5.Peer-Reviewed Original ResearchClearance of Large Amounts of Natural Surfactants and Liposomes of Dipalmitoylphosphatidylcholine from the Lungs of Rabbits
Oguchi K, Ikegami M, Jacobs H, Jobe A. Clearance of Large Amounts of Natural Surfactants and Liposomes of Dipalmitoylphosphatidylcholine from the Lungs of Rabbits. Experimental Lung Research 1985, 9: 221-235. PMID: 3841050, DOI: 10.3109/01902148509057525.Peer-Reviewed Original ResearchConceptsTotal lungLung tissueRabbit surfactantAlveolar washSheep surfactantAlveolar surfactant pool sizeEndogenous surfactant metabolismEndogenous surfactant poolsSurfactant pool sizeDifferent surfactant preparationsNatural rabbit surfactantLungs of rabbitsNatural sheep surfactantIntratracheal administrationIntratracheal injectionLung phosphatidylcholineSurfactant poolQuantity of phosphatidylcholineSurfactant metabolismLungClearance rateSurfactant phosphatidylcholineTotal phosphatidylcholineMetabolic responseSurfactant preparations
1984
Reutilization of phosphatidylcholine analogues by the pulmonary surfactant system The lack of specificity
Jacobs H, Jobe A, Machiko I, Miller D, Jones S. Reutilization of phosphatidylcholine analogues by the pulmonary surfactant system The lack of specificity. Biochimica Et Biophysica Acta 1984, 793: 300-309. PMID: 6546884, DOI: 10.1016/0005-2760(84)90333-3.Peer-Reviewed Original ResearchAdrenal Epinephrine and the Regulation of Pulmonary Surfactant Release in Neonatal Rabbits
Padbury J, Jacobs H, Lam R, Conaway D, Jobe A, Fisher D. Adrenal Epinephrine and the Regulation of Pulmonary Surfactant Release in Neonatal Rabbits. Experimental Lung Research 1984, 7: 177-186. PMID: 6549291, DOI: 10.3109/01902148409087911.Peer-Reviewed Original ResearchConceptsAdrenal E contentPulmonary surfactant releaseSKF 29661Surfactant releaseFetal adrenal glandE contentEpinephrine synthesisMaternal doseNeonatal periodAdrenal epinephrineAdrenal glandPregnant rabbitsNeonatal rabbitsAlveolar washPhosphatidylcholine contentBirthRabbitsAgeReleaseEpinephrineDoseSecretion
1983
Route of incorporation of alveolar palmitate and choline into surfactant phosphatidylcholine in rabbits
Jacobs H, Jobe A, Ikegami M, Jones S, Miller D. Route of incorporation of alveolar palmitate and choline into surfactant phosphatidylcholine in rabbits. Biochimica Et Biophysica Acta 1983, 752: 178-181. PMID: 6687812, DOI: 10.1016/0005-2760(83)90246-1.Peer-Reviewed Original ResearchThe significance of reutilization of surfactant phosphatidylcholine.
Jacobs H, Jobe A, Ikegami M, Conaway D. The significance of reutilization of surfactant phosphatidylcholine. Journal Of Biological Chemistry 1983, 258: 4159-4165. PMID: 6687593, DOI: 10.1016/s0021-9258(18)32599-7.Peer-Reviewed Original Research
1982
Surfactant phosphatidylcholine source, fluxes, and turnover times in 3-day-old, 10-day-old, and adult rabbits.
Jacobs H, Jobe A, Ikegami M, Jones S. Surfactant phosphatidylcholine source, fluxes, and turnover times in 3-day-old, 10-day-old, and adult rabbits. Journal Of Biological Chemistry 1982, 257: 1805-1810. PMID: 7035455, DOI: 10.1016/s0021-9258(19)68109-3.Peer-Reviewed Original Research
1981
Changes in the amount of lung and airway phosphatidylcholine in 0.5–12.5-day-old rabbits
Jobe A, Ikegami M, Jacobs H. Changes in the amount of lung and airway phosphatidylcholine in 0.5–12.5-day-old rabbits. Biochimica Et Biophysica Acta 1981, 664: 182-187. PMID: 6894550, DOI: 10.1016/0005-2760(81)90040-0.Peer-Reviewed Original Research