2003
Impaired B cell development and function in mice with a targeted disruption of the homeobox gene Hex
Bogue CW, Zhang PX, McGrath J, Jacobs HC, Fuleihan RL. Impaired B cell development and function in mice with a targeted disruption of the homeobox gene Hex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 556-561. PMID: 12522149, PMCID: PMC141034, DOI: 10.1073/pnas.0236979100.Peer-Reviewed Original ResearchConceptsB cell developmentB cellsChimeric miceT cell-dependent antigensT cell-independent antigensSerum IgM levelsCell developmentMature B cellsIgM levelsImpaired B cell developmentAntibody responseIgG antibodiesPlasma cellsBone marrowAbsence of HexLymphocyte developmentMiceTargeted disruptionHomozygous disruptionAntigenCellsHomeobox gene HexMarrowDramatic increaseAntibodies
2001
Defining the specific physiological requirements for c-Myc in T cell development
Douglas N, Jacobs H, Bothwell A, Hayday A. Defining the specific physiological requirements for c-Myc in T cell development. Nature Immunology 2001, 2: 307-315. PMID: 11276201, DOI: 10.1038/86308.Peer-Reviewed Original ResearchConceptsDevelopmental gene expressionC-MycSpecific physiological requirementsMYC family membersT cell developmentAbstractc-MycN-myc expressionGene expressionDeregulated expressionCell developmentCell growthPhysiological requirementsAge-dependent mannerThymocyte maturationDN stageNormal lymphocytesExpressionNonredundant contributionsDistinct patternsFamily membersCellsLymphomagenesisMaturationLymphocytes