2009
Frame‐shifts of digit identity in bird evolution and Cyclopamine‐treated wings
Vargas AO, Wagner GP. Frame‐shifts of digit identity in bird evolution and Cyclopamine‐treated wings. Evolution & Development 2009, 11: 163-169. PMID: 19245548, DOI: 10.1111/j.1525-142x.2009.00317.x.Peer-Reviewed Original ResearchMeSH KeywordsAlligators and CrocodilesAnimalsBirdsBody PatterningCartilageEvolution, MolecularFrameshift MutationGene Expression Regulation, DevelopmentalHomeodomain ProteinsMicePhenotypeTime FactorsVeratrum AlkaloidsWings, Animal
2008
Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals
Lynch VJ, Tanzer A, Wang Y, Leung FC, Gellersen B, Emera D, Wagner GP. Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14928-14933. PMID: 18809929, PMCID: PMC2567470, DOI: 10.1073/pnas.0802355105.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsChickensElephantsEndometriumEvolution, MolecularFemaleGene Expression Regulation, DevelopmentalHomeodomain ProteinsHumansMiceMolecular Sequence DataOpossumsPlacentaPregnancyProlactinPromoter Regions, GeneticSelection, GeneticConceptsCis-regulatory elementsHoxa-11Evolutionary changePlacental mammalsEutherian mammalsTranscription factorsCis-regulatory evolutionDirect regulatory targetsGene expression domainsStrong positive selectionNovel developmental pathwayPRL expressionTherian ancestorGene regulationExpression domainsPositive selectionRegulatory targetsNovel functionDevelopmental pathwaysMammalsSpatial expressionProlactin expressionGenesExpressionAdaptive changesThe gene regulatory logic of transcription factor evolution
Wagner GP, Lynch VJ. The gene regulatory logic of transcription factor evolution. Trends In Ecology & Evolution 2008, 23: 377-385. PMID: 18501470, DOI: 10.1016/j.tree.2008.03.006.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsEvolution, MolecularGene Expression Regulation, DevelopmentalHumansModels, GeneticMolecular Sequence DataProteinsRegulatory Elements, TranscriptionalTranscription FactorsConceptsTranscription factor proteinsDevelopmental evolutionGene regulatory logicMinimal pleiotropic effectsTranscription factor evolutionFactor proteinTranscription factor functionEvolution of developmentTranscription factor genesCis-regulatory elementsFunction of proteinsAdaptive evolutionDevelopmental biologyRegulatory logicNovel functionFactor genesFactor functionProtein changesPleiotropic effectsProteinRecent studiesEvolutionGenesRelative contributionBiology
2007
The developmental genetics of homology
Wagner GP. The developmental genetics of homology. Nature Reviews Genetics 2007, 8: 473-479. PMID: 17486120, DOI: 10.1038/nrg2099.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological EvolutionDevelopmental BiologyEyeGene Expression Regulation, DevelopmentalGenes, HomeoboxGeneticsHumansModels, GeneticTranscription FactorsA stochastic model for the evolution of transcription factor binding site abundance
Wagner GP, Otto W, Lynch V, Stadler PF. A stochastic model for the evolution of transcription factor binding site abundance. Journal Of Theoretical Biology 2007, 247: 544-553. PMID: 17475285, DOI: 10.1016/j.jtbi.2007.03.001.Peer-Reviewed Original ResearchAnimalsDNA-Binding ProteinsEvolution, MolecularGene Expression Regulation, DevelopmentalGenes, HomeoboxGenomeHumansModels, GeneticPlant ProteinsStochastic ProcessesTranscription Factors
2001
What is the promise of developmental evolution? Part II: A causal explanation of evolutionary innovations may be impossible
Wagner G. What is the promise of developmental evolution? Part II: A causal explanation of evolutionary innovations may be impossible. Journal Of Experimental Zoology 2001, 291: 305-309. PMID: 11754010, DOI: 10.1002/jez.1130.Commentaries, Editorials and LettersMeSH KeywordsAnimalsBiological EvolutionDevelopmental BiologyDrosophila melanogasterGene Expression Regulation, DevelopmentalModels, TheoreticalPhenotypeResearchSelection, GeneticXenopusThe tetrapod limb: A hypothesis on its origin
Wagner G, Chiu C. The tetrapod limb: A hypothesis on its origin. Journal Of Experimental Zoology 2001, 291: 226-240. PMID: 11598912, DOI: 10.1002/jez.1100.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdaptation, PhysiologicalAnimalsBiological EvolutionEcosystemExtremitiesFossilsGene Expression Regulation, DevelopmentalHomeodomain ProteinsVertebratesConceptsTetrapod limbsExpression domainsHoxa-13Hoxa-11Fin-limb transitionExclusive expression domainsMajor morphological adaptationsProximal-distal axisVertebrate evolutionFin developmentHoxa-11 expressionTerrestrial lifestyleFin skeletonMorphological adaptationsDevelopmental mechanismsExpression patternsLimb budPaleontological evidenceGenetic hypothesisExpressionZebrafishEvolutionHomologyAquaticGenes