2008
Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals
Lynch VJ, Tanzer A, Wang Y, Leung FC, Gellersen B, Emera D, Wagner GP. Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14928-14933. PMID: 18809929, PMCID: PMC2567470, DOI: 10.1073/pnas.0802355105.Peer-Reviewed Original ResearchConceptsCis-regulatory elementsHoxa-11Evolutionary changePlacental mammalsEutherian mammalsTranscription factorsCis-regulatory evolutionDirect regulatory targetsGene expression domainsStrong positive selectionNovel developmental pathwayPRL expressionTherian ancestorGene regulationExpression domainsPositive selectionRegulatory targetsNovel functionDevelopmental pathwaysMammalsSpatial expressionProlactin expressionGenesExpressionAdaptive changesPleiotropic scaling of gene effects and the ‘cost of complexity’
Wagner GP, Kenney-Hunt JP, Pavlicev M, Peck JR, Waxman D, Cheverud JM. Pleiotropic scaling of gene effects and the ‘cost of complexity’. Nature 2008, 452: 470-472. PMID: 18368117, DOI: 10.1038/nature06756.Peer-Reviewed Original ResearchConceptsQuantitative trait lociEffects of pleiotropyOrganismal complexityGenetic sequence dataHigher organismsEvolutionary biologyTrait lociMouse genomeSequence dataBiology questionsSkeletal traitsGene effectsMost mutationsCost of complexityGenetic mutationsTraitsMutationsMultiple effectsGenomeSkeletal characteristicsPleiotropyLociPleiotropicOrganismsBiology
2001
What is the promise of developmental evolution? Part II: A causal explanation of evolutionary innovations may be impossible
Wagner G. What is the promise of developmental evolution? Part II: A causal explanation of evolutionary innovations may be impossible. Journal Of Experimental Zoology 2001, 291: 305-309. PMID: 11754010, DOI: 10.1002/jez.1130.Commentaries, Editorials and LettersModeling Genetic Architecture: A Multilinear Theory of Gene Interaction
Hansen T, Wagner G. Modeling Genetic Architecture: A Multilinear Theory of Gene Interaction. Theoretical Population Biology 2001, 59: 61-86. PMID: 11243929, DOI: 10.1006/tpbi.2000.1508.Peer-Reviewed Original ResearchConceptsGenotype-phenotype mapGene interactionsQuantitative genetic variationEffects of epistasisGenetic canalizationGenetic experimentsGenetic variationGene substitutionGenetic backgroundEpistasisTractable modelComplex functionsCentral importanceLociBiologyCanalizationPhenotypeGenotypesInteractionSum of linear
1996
Apparent Stabilizing Selection and the Maintenance of Neutral Genetic Variation
Wagner G. Apparent Stabilizing Selection and the Maintenance of Neutral Genetic Variation. Genetics 1996, 143: 617-619. PMID: 8722811, PMCID: PMC1207295, DOI: 10.1093/genetics/143.1.617.Peer-Reviewed Original Research
1985
On the evolution of dominance modifiers II: a non-equilibrium approach to the evolution of genetic systems
Wagner G, Bürger R. On the evolution of dominance modifiers II: a non-equilibrium approach to the evolution of genetic systems. Journal Of Theoretical Biology 1985, 113: 475-500. PMID: 3999784, DOI: 10.1016/s0022-5193(85)80034-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological EvolutionDrosophilaGenes, DominantMathematicsModels, GeneticMothsSelection, Genetic