2012
Coming to Grips with Evolvability
Pavlicev M, Wagner G. Coming to Grips with Evolvability. Evolution: Education And Outreach 2012, 5: 231-244. DOI: 10.1007/s12052-012-0430-1.Peer-Reviewed Original ResearchGenotype-phenotype mapOrganismal developmentMost genesCryptic mutationsPhenotypic traitsComplex organismsPhenotypic charactersMost traitsRandom mutationsReal organismsGenetic effectsEvolvabilityGenetic backgroundOrganismsGenesMutationsTraitsNew environmentRandom changesPhenotypeFitnessEvolutionSelectionConventional computer languages
2009
Measuring Evolutionary Constraints Through the Dimensionality of the Phenotype: Adjusted Bootstrap Method to Estimate Rank of Phenotypic Covariance Matrices
Pavlicev M, Wagner G, Cheverud J. Measuring Evolutionary Constraints Through the Dimensionality of the Phenotype: Adjusted Bootstrap Method to Estimate Rank of Phenotypic Covariance Matrices. Evolutionary Biology 2009, 36: 339-353. DOI: 10.1007/s11692-009-9066-7.Peer-Reviewed Original ResearchEvolutionary constraintsCovariance matrixPhenotypic covariance matrixGenetic covariance matrixPhenotypic evolutionBootstrap methodPhenotypic variationGenetic variationPhenotype spaceLack of variationSelection responseFull rankMatrix rankRank estimatesNumber of variablesPhenotypeVariational dimensionsDimensionalityPhenotypicTraitsConstraintsMatrixVariationRankSample sizeMeasuring Morphological Integration Using Eigenvalue Variance
Pavlicev M, Cheverud J, Wagner G. Measuring Morphological Integration Using Eigenvalue Variance. Evolutionary Biology 2009, 36: 157-170. DOI: 10.1007/s11692-008-9042-7.Peer-Reviewed Original Research
2008
Pleiotropic scaling of gene effects and the ‘cost of complexity’
Wagner GP, Kenney-Hunt JP, Pavlicev M, Peck JR, Waxman D, Cheverud JM. Pleiotropic scaling of gene effects and the ‘cost of complexity’. Nature 2008, 452: 470-472. PMID: 18368117, DOI: 10.1038/nature06756.Peer-Reviewed Original ResearchConceptsQuantitative trait lociEffects of pleiotropyOrganismal complexityGenetic sequence dataHigher organismsEvolutionary biologyTrait lociMouse genomeSequence dataBiology questionsSkeletal traitsGene effectsMost mutationsCost of complexityGenetic mutationsTraitsMutationsMultiple effectsGenomeSkeletal characteristicsPleiotropyLociPleiotropicOrganismsBiology
2007
The road to modularity
Wagner GP, Pavlicev M, Cheverud JM. The road to modularity. Nature Reviews Genetics 2007, 8: 921-931. PMID: 18007649, DOI: 10.1038/nrg2267.Peer-Reviewed Original ResearchConceptsProtein-protein interaction networkMolecular systems biologyPatterns of evolutionGene duplicationGene regulationEvolutionary biologyNeutral mutationsBiological organizationQuantitative traitsInteraction networksSystems biologyStructure of macromoleculesEnvironmental conditionsBiologyDuplicationTraitsMutationsRegulationSelectionModularityMacromolecules
2006
EVIDENCE FOR THE REVERSIBILITY OF DIGIT LOSS: A PHYLOGENETIC STUDY OF LIMB EVOLUTION IN BACHIA (GYMNOPHTHALMIDAE: SQUAMATA)
Kohlsdorf T, Wagner GP. EVIDENCE FOR THE REVERSIBILITY OF DIGIT LOSS: A PHYLOGENETIC STUDY OF LIMB EVOLUTION IN BACHIA (GYMNOPHTHALMIDAE: SQUAMATA). Evolution 2006, 60: 1896-1912. PMID: 17089974, DOI: 10.1111/j.0014-3820.2006.tb00533.x.Peer-Reviewed Original ResearchConceptsDigit lossSouth American genusMolecular phylogenyLimb evolutionComplex traitsPhylogenetic studiesEvolutionary changeBachiaAmerican generaGenetic informationDigit numberReevolutionMost membersSpecific phenotypesTraitsStrong evidencePhylogenyVisible effectTaxaGenusGenesMorphological structurePhenotypeEvolutionLimited numberEVIDENCE FOR THE REVERSIBILITY OF DIGIT LOSS: A PHYLOGENETIC STUDY OF LIMB EVOLUTION IN BACHIA (GYMNOPHTHALMIDAE: SQUAMATA)
Kohlsdorf T, Wagner G. EVIDENCE FOR THE REVERSIBILITY OF DIGIT LOSS: A PHYLOGENETIC STUDY OF LIMB EVOLUTION IN BACHIA (GYMNOPHTHALMIDAE: SQUAMATA). Evolution 2006, 60: 1896-1912. DOI: 10.1554/06-056.1.Peer-Reviewed Original ResearchDigit lossSouth American genusMolecular phylogenyLimb evolutionComplex traitsPhylogenetic studiesEvolutionary changeBachiaAmerican generaGenetic informationDigit numberReevolutionMost membersSpecific phenotypesTraitsStrong evidencePhylogenyVisible effectTaxaGenusGenesMorphological structurePhenotypeEvolutionLimited number
2000
Canalization in evolutionary genetics: a stabilizing theory?
Gibson G, Wagner G. Canalization in evolutionary genetics: a stabilizing theory? BioEssays 2000, 22: 372-380. PMID: 10723034, DOI: 10.1002/(sici)1521-1878(200004)22:4<372::aid-bies7>3.0.co;2-j.Commentaries, Editorials and LettersCharacter identification in evolutionary biology: The role of the organism
Wagner G, Laubichler M. Character identification in evolutionary biology: The role of the organism. Theory In Biosciences 2000, 119: 20-40. DOI: 10.1007/s12064-000-0003-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBiological processesBiological charactersImportant biological charactersHigher-level biological processesAdaptive evolutionEvolutionary biologyMathematical theoryRelevant charactersMathematical modelCharacter decompositionOrganismsBiologyOrganismic perspectiveBiological modelsPhysical sciencesBiological theoryIdentificationTheoryTraitsInheritanceModelAnalytical methodCellsCharacterAppropriate instances