2008
Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals
Lynch VJ, Tanzer A, Wang Y, Leung FC, Gellersen B, Emera D, Wagner GP. Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14928-14933. PMID: 18809929, PMCID: PMC2567470, DOI: 10.1073/pnas.0802355105.Peer-Reviewed Original ResearchConceptsCis-regulatory elementsHoxa-11Evolutionary changePlacental mammalsEutherian mammalsTranscription factorsCis-regulatory evolutionDirect regulatory targetsGene expression domainsStrong positive selectionNovel developmental pathwayPRL expressionTherian ancestorGene regulationExpression domainsPositive selectionRegulatory targetsNovel functionDevelopmental pathwaysMammalsSpatial expressionProlactin expressionGenesExpressionAdaptive changes
1993
How can a character be developmentally constrained despite variation in developmental pathways?
Wagner G, Misof B. How can a character be developmentally constrained despite variation in developmental pathways? Journal Of Evolutionary Biology 1993, 6: 449-455. DOI: 10.1046/j.1420-9101.1993.6030449.x.Commentaries, Editorials and LettersDevelopmental constraintsDevelopmental biologyDevelopmental pathwaysEvolutionary developmental biologyComparative developmental biologyDevelopmental variationBody planAdaptive pressuresConservative patternAdult variationFundamental riddleHomologyBiologyBiological basisConservationPathwayAnatomical featuresMorphological patternsHomologuesEarly perturbationsVariationPatternsEarly stagesAdult patternFunction