2023
Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo
Spies M, Murgaš M, Vraka C, Philippe C, Gryglewski G, Nics L, Balber T, Baldinger-Melich P, Hartmann A, Rujescu D, Hacker M, Winkler-Pjrek E, Winkler D, Lanzenberger R. Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo. Translational Psychiatry 2023, 13: 208. PMID: 37322010, PMCID: PMC10272199, DOI: 10.1038/s41398-023-02506-2.Peer-Reviewed Original ResearchConceptsMAO-A levelsMAO-A VTSerotonin turnoverCerebral serotonin systemPositron emission tomography studyGenetic variantsEmission tomography studiesTryptophan hydroxylase 2 geneCerebral MAODepressed cohortBrain MAOMonoamine oxidase ASerotonin systemRelated clinical phenomenaRs1386494Distribution volumeTPH2 polymorphismsTomography studyClinical phenomenaMonoamine oxidase
2022
ABCB1 variants and sex affect serotonin transporter occupancy in the brain
Silberbauer LR, Rischka L, Vraka C, Hartmann AM, Godbersen GM, Philippe C, Pacher D, Nics L, Klöbl M, Unterholzner J, Stimpfl T, Wadsak W, Hahn A, Hacker M, Rujescu D, Kasper S, Lanzenberger R, Gryglewski G. ABCB1 variants and sex affect serotonin transporter occupancy in the brain. Molecular Psychiatry 2022, 27: 4502-4509. PMID: 36071112, PMCID: PMC7613909, DOI: 10.1038/s41380-022-01733-1.Peer-Reviewed Original ResearchConceptsMinor allele carriersTransporter occupancyAllele carriersABCB1 single nucleotide polymorphismsBasic clinical variablesCitalopram plasma concentrationsYears of ageMajor allele homozygotesCross-over designPET/MRISERT occupancyClinical variablesTreatment promisesClinical algorithmMajor depressionPlasma concentrationsPrecision pharmacotherapyABCB1 variantsHealthy volunteersABCB1 geneAllele homozygotesSame dosageDrug-target engagementTarget engagementSingle nucleotide polymorphismsRegional gene expression patterns are associated with task‐specific brain activation during reward and emotion processing measured with functional MRI
Komorowski A, Murgaš M, Vidal R, Singh A, Gryglewski G, Kasper S, Wiltfang J, Lanzenberger R, Goya‐Maldonado R. Regional gene expression patterns are associated with task‐specific brain activation during reward and emotion processing measured with functional MRI. Human Brain Mapping 2022, 43: 5266-5280. PMID: 35796185, PMCID: PMC9812247, DOI: 10.1002/hbm.26001.Peer-Reviewed Original ResearchCorrelation of receptor density and mRNA expression patterns in the human cerebral cortex
Murgaš M, Michenthaler P, Reed MB, Gryglewski G, Lanzenberger R. Correlation of receptor density and mRNA expression patterns in the human cerebral cortex. NeuroImage 2022, 256: 119214. PMID: 35452805, DOI: 10.1016/j.neuroimage.2022.119214.Peer-Reviewed Original ResearchConceptsMRNA expression patternsExpression patternsPost-translational processesGene expression patternsRNA sequencing dataComprehensive proteomic studyMolecular targetsMulti-receptor systemsMessenger ribonucleic acid transcriptsRibonucleic acid transcriptsTranscriptome dataProteomic informationProteomic dataProteomic studiesMost proteinsSequencing dataVivo linkMicroarray dataAllen Human Brain AtlasMRNA expressionProtein densitySubunits α3ProteinHuman Brain AtlasHigh-resolution topologySimultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual
Vraka C, Murgaš M, Rischka L, Geist BK, Lanzenberger R, Gryglewski G, Zenz T, Wadsak W, Mitterhauser M, Hacker M, Philippe C, Pichler V. Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual. Scientific Reports 2022, 12: 3283. PMID: 35228586, PMCID: PMC8885643, DOI: 10.1038/s41598-022-06906-0.Peer-Reviewed Original ResearchEscitalopram administration, relearning, and neuroplastic effects: A diffusion tensor imaging study in healthy individuals
Vanicek T, Reed MB, Unterholzner J, Klöbl M, Godbersen GM, Handschuh PA, Spurny-Dworak B, Ritter V, Gryglewski G, Kraus C, Winkler D, Lanzenberger R, Seiger R. Escitalopram administration, relearning, and neuroplastic effects: A diffusion tensor imaging study in healthy individuals. Journal Of Affective Disorders 2022, 301: 426-432. PMID: 35016914, DOI: 10.1016/j.jad.2021.12.135.Peer-Reviewed Original ResearchSerotonergic modulation of effective connectivity in an associative relearning network during task and rest
Reed MB, Klöbl M, Godbersen GM, Handschuh PA, Ritter V, Spurny-Dworak B, Unterholzner J, Kraus C, Gryglewski G, Winkler D, Seiger R, Vanicek T, Hahn A, Lanzenberger R. Serotonergic modulation of effective connectivity in an associative relearning network during task and rest. NeuroImage 2022, 249: 118887. PMID: 34999203, DOI: 10.1016/j.neuroimage.2022.118887.Peer-Reviewed Original ResearchConceptsRight angular gyrusAnterior cingulate cortexEffective connectivityRight insulaCognitive flexibilityAngular gyrusCingulate cortexAssociative learning taskAssociative learningLearning taskTask connectivityLearning phaseInsulaGray matter volume changesSelective serotonin reuptake inhibitor escitalopramDouble-blind designNeuroplastic changesGyrusTaskParticipantsSSRI intakeCortexEffective connectionSerotonergic modulationConnectivity
2021
Coexpression of Gene Transcripts with Monoamine Oxidase A Quantified by Human In Vivo Positron Emission Tomography
Godbersen GM, Murgaš M, Gryglewski G, Klöbl M, Unterholzner J, Rischka L, Spies M, Baldinger-Melich P, Winkler D, Lanzenberger R. Coexpression of Gene Transcripts with Monoamine Oxidase A Quantified by Human In Vivo Positron Emission Tomography. Cerebral Cortex 2021, 32: 3516-3524. PMID: 34952543, DOI: 10.1093/cercor/bhab430.Peer-Reviewed Original ResearchConceptsExact testPositron emission tomography scanCerebral distribution volumeMonoamine oxidaseEmission tomography scanNovel therapeutic targetVivo positron emission tomographyFisher's exact testPositron emission tomographyFalse discovery rate correctionVivo MAOTomography scanHealthy subjectsSubcortical areasCortical areasTherapeutic targetMAOA expressionDistribution volumeEmission tomographyNeuropsychiatric disordersNeuron projectionsNeuron developmentNeuron differentiationSpearman's ρCell-cell signalingEscitalopram modulates learning content-specific neuroplasticity of functional brain networks
Klöbl M, Seiger R, Vanicek T, Handschuh P, Reed MB, Spurny-Dworak B, Ritter V, Godbersen GM, Gryglewski G, Kraus C, Hahn A, Lanzenberger R. Escitalopram modulates learning content-specific neuroplasticity of functional brain networks. NeuroImage 2021, 247: 118829. PMID: 34923134, DOI: 10.1016/j.neuroimage.2021.118829.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexSelective serotonin reuptake inhibitorsPrefrontal cortexBroca's areaLingual gyrusFunctional connectivityFunctional magnetic resonance imagingResting-state functional magnetic resonance imagingFunctional brain networksBrain functional connectivityFear extinctionComplexity of learningSerotonin reuptake inhibitorsHuman neuroplasticityBrain networksMagnetic resonance imagingEscitalopram intakeComparable modulationClinical improvementSSRI escitalopramDaily doseReuptake inhibitorsNeuroplastic changesHealthy subjectsNeuroplasticityFirst-in-Humans Brain PET Imaging of the GluN2B-Containing N-methyl-d-aspartate Receptor with (R)-11C-Me-NB1
Rischka L, Vraka C, Pichler V, Rasul S, Nics L, Gryglewski G, Handschuh P, Murgaš M, Godbersen GM, Silberbauer LR, Unterholzner J, Wotawa C, Haider A, Ahmed H, Schibli R, Mindt T, Mitterhauser M, Wadsak W, Hahn A, Lanzenberger R, Hacker M, Ametamey SM. First-in-Humans Brain PET Imaging of the GluN2B-Containing N-methyl-d-aspartate Receptor with (R)-11C-Me-NB1. Journal Of Nuclear Medicine 2021, 63: 936-941. PMID: 34620732, PMCID: PMC9157734, DOI: 10.2967/jnumed.121.262427.Peer-Reviewed Original ResearchMeta-analysis of brain structural changes after electroconvulsive therapy in depression
Gryglewski G, Lanzenberger R, Silberbauer LR, Pacher D, Kasper S, Rupprecht R, Frey R, Baldinger-Melich P. Meta-analysis of brain structural changes after electroconvulsive therapy in depression. Brain Stimulation 2021, 14: 927-937. PMID: 34119669, DOI: 10.1016/j.brs.2021.05.014.Peer-Reviewed Original ResearchConceptsElectroconvulsive therapyDentate gyrusHippocampal subfieldsSignificant volume increaseSeries of ECTStandardized mean change scoresBrain structuresLongitudinal magnetic resonance imagingBrain structural changesCornu ammonis 1Mean change scoresRegional brain volumesRandom-effects modelMagnetic resonance imagingClinical outcomesSymptom improvementDepressive patientsTreatment outcomesStandardized mean changeBilateral hippocampusIndividual patientsMean changeBrain volumeWarrant replicationResonance imagingNeuroplastic effects of a selective serotonin reuptake inhibitor in relearning and retrieval
Reed MB, Vanicek T, Seiger R, Klöbl M, Spurny B, Handschuh P, Ritter V, Unterholzner J, Godbersen GM, Gryglewski G, Kraus C, Winkler D, Hahn A, Lanzenberger R. Neuroplastic effects of a selective serotonin reuptake inhibitor in relearning and retrieval. NeuroImage 2021, 236: 118039. PMID: 33852940, PMCID: PMC7610799, DOI: 10.1016/j.neuroimage.2021.118039.Peer-Reviewed Original ResearchConceptsLeft angular gyrusAngular gyrusMemory retrievalAssociative learningLearning taskAssociative learning taskFunctional MRI sessionsRetrieval tasksTime interactionFunctional brain activationInsula activationExecutive functionCognitive functioningBrain activationGreater deactivationTask performanceTime interaction effectsMRI scanning sessionsRight insulaSubsequent retrievalNeuroplastic effectsLearning phaseScanning sessionSelective serotonin reuptake inhibitorsNeuroplastic processesDifferential patterns of gray matter volumes and associated gene expression profiles in cognitively-defined Alzheimer’s disease subgroups
Groot C, Grothe MJ, Mukherjee S, Jelistratova I, Jansen I, van Loenhoud AC, Risacher SL, Saykin AJ, Mac Donald C, Mez J, Trittschuh EH, Gryglewski G, Lanzenberger R, Pijnenburg YAL, Barkhof F, Scheltens P, van der Flier WM, Crane PK, Ossenkoppele R. Differential patterns of gray matter volumes and associated gene expression profiles in cognitively-defined Alzheimer’s disease subgroups. NeuroImage Clinical 2021, 30: 102660. PMID: 33895633, PMCID: PMC8186562, DOI: 10.1016/j.nicl.2021.102660.Peer-Reviewed Original ResearchConceptsGray matter volumeRegional GM volumeAd memoryAd executivesGM volumeMatter volumeRegional gray matter volumeVoxel-wise contrastsAlzheimer’s disease subgroupsCognitive domainsCognitive profileNeuropsychological assessmentNeurobiological mechanismsNeurobiological differencesPsychometric frameworkAd languageRelative impairmentTemporal lobeHuman brainAllen Human Brain AtlasDifferential patternsStructural MRILower GM volumeHuman Brain AtlasPosterior areasEnrichment of Disease-Associated Genes in Cortical Areas Defined by Transcriptome-Based Parcellation
Gryglewski G, Murgaš M, Klöbl M, Reed MB, Unterholzner J, Michenthaler P, Lanzenberger R. Enrichment of Disease-Associated Genes in Cortical Areas Defined by Transcriptome-Based Parcellation. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 7: 10-23. PMID: 33711548, DOI: 10.1016/j.bpsc.2021.02.012.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGene setsEnrichment analysisAssociation studiesDistinct gene expression profilesCortical areasDisease-associated genesGene expression profilesEnrichment patternsSimilar enrichment patternsExpert-curated databasesNovel disease mechanismsTranscriptome dataBrain disordersPleiotropic genesSpecific genesExpression profilesGenesMicroarray dataSpecific cortical areasAmyotrophic lateral sclerosisInferior parietal lobuleFunctional differentiationTranscriptomeRegional enrichmentThe Influence of Acute SSRI Administration on White Matter Microstructure in Patients Suffering From Major Depressive Disorder and Healthy Controls
Seiger R, Gryglewski G, Klöbl M, Kautzky A, Godbersen GM, Rischka L, Vanicek T, Hienert M, Unterholzner J, Silberbauer LR, Michenthaler P, Handschuh P, Hahn A, Kasper S, Lanzenberger R. The Influence of Acute SSRI Administration on White Matter Microstructure in Patients Suffering From Major Depressive Disorder and Healthy Controls. The International Journal Of Neuropsychopharmacology 2021, 24: 542-550. PMID: 33667309, PMCID: PMC8299824, DOI: 10.1093/ijnp/pyab008.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsMajor depressive disorderSSRI administrationDepressive disorderAxial diffusivityRadial diffusivityMean diffusivityFractional anisotropySerotonin transporterInterventional longitudinal studySerotonin reuptake inhibitorsLevels of serotoninWM microstructureAcute SSRI administrationTract-based spatial statisticsWhite matter alterationsAnterior corona radiataBrain WM microstructureCross-over designAntidepressant therapySSRI treatmentReuptake inhibitorsWhite matter microstructureRepeated-measures ANOVA modelsExternal capsuleEffects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm
Spurny B, Vanicek T, Seiger R, Reed MB, Klöbl M, Ritter V, Unterholzner J, Godbersen GM, Silberbauer LR, Pacher D, Klug S, Konadu ME, Gryglewski G, Trattnig S, Bogner W, Lanzenberger R. Effects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm. NeuroImage 2021, 232: 117913. PMID: 33657450, PMCID: PMC7610796, DOI: 10.1016/j.neuroimage.2021.117913.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsGamma-aminobutyric acidMajor depressive disorderSerotonin reuptake inhibitorsSSRI treatmentPlacebo administrationReuptake inhibitorsGlutamatergic functionGlutamatergic neurotransmissionDepressive disorderNeuroplastic effectsSerotonergic systemNeurotransmitter systemsHealthy subjectsPsychiatric disordersImpaired cognitive flexibilityBrain regionsNeurotransmitter concentrationsCognitive functionWidespread symptomsMemory formationLast dayDisordersDownstream effectsTreatment
2020
Topologically Guided Prioritization of Candidate Gene Transcripts Coexpressed with the 5-HT1A Receptor by Combining In Vivo PET and Allen Human Brain Atlas Data
Unterholzner J, Gryglewski G, Philippe C, Seiger R, Pichler V, Godbersen GM, Berroterán-Infante N, Murgaš M, Hahn A, Wadsak W, Mitterhauser M, Kasper S, Lanzenberger R. Topologically Guided Prioritization of Candidate Gene Transcripts Coexpressed with the 5-HT1A Receptor by Combining In Vivo PET and Allen Human Brain Atlas Data. Cerebral Cortex 2020, 30: 3771-3780. PMID: 31989157, PMCID: PMC7232988, DOI: 10.1093/cercor/bhz341.Peer-Reviewed Original ResearchConceptsMRNA expressionRole of BDNFSerotonin 1A receptorEfficacy of drugsTreatment of disordersReceptor subtypesHealthy subjectsPsychiatric drugsBrain tissueCortical regionsVivo PETSerotonergic functioningViable targetDrugsSpearman's rhoCandidate gene transcriptsReceptorsCoexpression patternsRelative inaccessibility
2019
Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression
Gryglewski G, Seiger R, Baldinger-Melich P, Unterholzner J, Spurny B, Vanicek T, Hahn A, Kasper S, Frey R, Lanzenberger R. Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression. The International Journal Of Neuropsychopharmacology 2019, 23: 20-25. PMID: 31740958, PMCID: PMC7064047, DOI: 10.1093/ijnp/pyz059.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionElectroconvulsive therapyWhite matter microstructureRight unilateral electroconvulsive therapyDiffusivity metricsUnipolar treatment-resistant depressionPoor antidepressant responseEffective therapeutic optionUnilateral electroconvulsive therapyDiffusion tensor imaging sequencesElectrode placementTract-based spatial statisticsAntidepressant responseClinical outcomesTherapeutic optionsInternal capsuleRepeated-measures ANOVAPosterior limbTreatment responseMagnetic resonanceElectrical stimulationTherapyAxial diffusivityLeft hemisphereWarrants investigationHippocampal GABA levels correlate with retrieval performance in an associative learning paradigm
Spurny B, Seiger R, Moser P, Vanicek T, Reed MB, Heckova E, Michenthaler P, Basaran A, Gryglewski G, Klöbl M, Trattnig S, Kasper S, Bogner W, Lanzenberger R. Hippocampal GABA levels correlate with retrieval performance in an associative learning paradigm. NeuroImage 2019, 204: 116244. PMID: 31606475, PMCID: PMC7610791, DOI: 10.1016/j.neuroimage.2019.116244.Peer-Reviewed Original ResearchConceptsHippocampal GABA levelsGABA levelsLong-term depressionLong-term potentiationHealthy participantsChanges of GABAMain inhibitory neurotransmitterMulti-voxel magnetic resonance spectroscopyMemory formationBaseline GABA levelsLongitudinal study designGlutamatergic systemInhibitory neurotransmitterNeuroplastic processesGlutamate concentrationNeural plasticityStudy designGABAAssociative learning paradigmThalamusHippocampusHuman brainInsulaNeurochemical underpinningsBrainAssociation of norepinephrine transporter methylation with in vivo NET expression and hyperactivity–impulsivity symptoms in ADHD measured with PET
Sigurdardottir HL, Kranz GS, Rami-Mark C, James GM, Vanicek T, Gryglewski G, Berroterán-Infante N, Kautzky A, Hienert M, Traub-Weidinger T, Mitterhauser M, Wadsak W, Hartmann AM, Hacker M, Rujescu D, Kasper S, Lanzenberger R. Association of norepinephrine transporter methylation with in vivo NET expression and hyperactivity–impulsivity symptoms in ADHD measured with PET. Molecular Psychiatry 2019, 26: 1009-1018. PMID: 31383926, PMCID: PMC7910214, DOI: 10.1038/s41380-019-0461-x.Peer-Reviewed Original Research