2019
Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression
Kautzky A, James GM, Philippe C, Baldinger-Melich P, Kraus C, Kranz GS, Vanicek T, Gryglewski G, Hartmann AM, Hahn A, Wadsak W, Mitterhauser M, Rujescu D, Kasper S, Lanzenberger R. Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression. Translational Psychiatry 2019, 9: 5. PMID: 30664620, PMCID: PMC6341100, DOI: 10.1038/s41398-018-0308-2.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor (BDNF) geneAffective disordersReceptor bindingSingle nucleotide polymorphismsPhenotype of depressionNeurotrophic factor geneSerotonin 1A receptor geneFunctional single nucleotide polymorphismsReceptor profileHealthy subjectsPET resultsRisk genotypesRs6265Multifactorial riskCortical regionsMixed modelsRisk allelesRs6295DisordersCortical surfaceReceptor geneReceptorsMolecular phenotypesHTR1ADepression
2017
Administration of ketamine for unipolar and bipolar depression
Kraus C, Rabl U, Vanicek T, Carlberg L, Popovic A, Spies M, Bartova L, Gryglewski G, Papageorgiou K, Lanzenberger R, Willeit M, Winkler D, Rybakowski JK, Kasper S. Administration of ketamine for unipolar and bipolar depression. International Journal Of Psychiatry In Clinical Practice 2017, 21: 2-12. PMID: 28097909, DOI: 10.1080/13651501.2016.1254802.Peer-Reviewed Original ResearchConceptsBipolar depressionSide effectsResponse rateMost common side effectsLong-term side effectsHamilton Depression Rating ScaleAntidepressant response ratesNausea/vomitingOpen-label trialRapid antidepressant efficacyTreatment-resistant depressionAnti-suicidal effectsCommon side effectsEfficacious treatment optionPrimary outcome measureAdministration of ketamineDepression Rating ScaleNew administration routesWeb of ScienceKetamine efficacyResistant depressionAntidepressant efficacyRelapse rateAntidepressant responseSafety profile
2016
Commentary: The serotonin transporter in depression: Meta-analysis of in vivo and post mortem findings and implications for understanding and treating depression
Cumming P, Gryglewski G, Kranz GS, Lanzenberger R. Commentary: The serotonin transporter in depression: Meta-analysis of in vivo and post mortem findings and implications for understanding and treating depression. Journal Of Affective Disorders 2016, 199: 21-22. PMID: 27057649, DOI: 10.1016/j.jad.2016.03.058.Peer-Reviewed Original ResearchMeSH KeywordsAutopsyDepressionDepressive DisorderHumansSerotoninSerotonin Plasma Membrane Transport Proteins