2022
Correlation of receptor density and mRNA expression patterns in the human cerebral cortex
Murgaš M, Michenthaler P, Reed MB, Gryglewski G, Lanzenberger R. Correlation of receptor density and mRNA expression patterns in the human cerebral cortex. NeuroImage 2022, 256: 119214. PMID: 35452805, DOI: 10.1016/j.neuroimage.2022.119214.Peer-Reviewed Original ResearchConceptsMRNA expression patternsExpression patternsPost-translational processesGene expression patternsRNA sequencing dataComprehensive proteomic studyMolecular targetsMulti-receptor systemsMessenger ribonucleic acid transcriptsRibonucleic acid transcriptsTranscriptome dataProteomic informationProteomic dataProteomic studiesMost proteinsSequencing dataVivo linkMicroarray dataAllen Human Brain AtlasMRNA expressionProtein densitySubunits α3ProteinHuman Brain AtlasHigh-resolution topology
2021
Neuroplastic effects of a selective serotonin reuptake inhibitor in relearning and retrieval
Reed MB, Vanicek T, Seiger R, Klöbl M, Spurny B, Handschuh P, Ritter V, Unterholzner J, Godbersen GM, Gryglewski G, Kraus C, Winkler D, Hahn A, Lanzenberger R. Neuroplastic effects of a selective serotonin reuptake inhibitor in relearning and retrieval. NeuroImage 2021, 236: 118039. PMID: 33852940, PMCID: PMC7610799, DOI: 10.1016/j.neuroimage.2021.118039.Peer-Reviewed Original ResearchConceptsLeft angular gyrusAngular gyrusMemory retrievalAssociative learningLearning taskAssociative learning taskFunctional MRI sessionsRetrieval tasksTime interactionFunctional brain activationInsula activationExecutive functionCognitive functioningBrain activationGreater deactivationTask performanceTime interaction effectsMRI scanning sessionsRight insulaSubsequent retrievalNeuroplastic effectsLearning phaseScanning sessionSelective serotonin reuptake inhibitorsNeuroplastic processes
2019
Hippocampal GABA levels correlate with retrieval performance in an associative learning paradigm
Spurny B, Seiger R, Moser P, Vanicek T, Reed MB, Heckova E, Michenthaler P, Basaran A, Gryglewski G, Klöbl M, Trattnig S, Kasper S, Bogner W, Lanzenberger R. Hippocampal GABA levels correlate with retrieval performance in an associative learning paradigm. NeuroImage 2019, 204: 116244. PMID: 31606475, PMCID: PMC7610791, DOI: 10.1016/j.neuroimage.2019.116244.Peer-Reviewed Original ResearchConceptsHippocampal GABA levelsGABA levelsLong-term depressionLong-term potentiationHealthy participantsChanges of GABAMain inhibitory neurotransmitterMulti-voxel magnetic resonance spectroscopyMemory formationBaseline GABA levelsLongitudinal study designGlutamatergic systemInhibitory neurotransmitterNeuroplastic processesGlutamate concentrationNeural plasticityStudy designGABAAssociative learning paradigmThalamusHippocampusHuman brainInsulaNeurochemical underpinningsBrain
2018
Structural changes in amygdala nuclei, hippocampal subfields and cortical thickness following electroconvulsive therapy in treatment-resistant depression: longitudinal analysis
Gryglewski G, Baldinger-Melich P, Seiger R, Godbersen GM, Michenthaler P, Klöbl M, Spurny B, Kautzky A, Vanicek T, Kasper S, Frey R, Lanzenberger R. Structural changes in amygdala nuclei, hippocampal subfields and cortical thickness following electroconvulsive therapy in treatment-resistant depression: longitudinal analysis. The British Journal Of Psychiatry 2018, 214: 159-167. PMID: 30442205, PMCID: PMC6383756, DOI: 10.1192/bjp.2018.224.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionElectroconvulsive therapyMagnetic resonance imagingCortical thicknessHippocampal subfieldsAmygdala nucleiHippocampal-amygdaloid transition areaRight unilateral electroconvulsive therapyEffects of ECTHigh-resolution structural magnetic resonance imagingUnipolar treatment-resistant depressionCorticoamygdaloid transition areaPathophysiology of depressionPre-post study designCorrelation of imagingUnilateral electroconvulsive therapyTreatment of choiceStructural magnetic resonance imagingSpecific hippocampal subfieldsSevere mental illnessGrant/research supportStress-related disordersClinical parametersRepeated-measures ANOVADentate gyrusParcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo
James GM, Gryglewski G, Vanicek T, Berroterán-Infante N, Philippe C, Kautzky A, Nics L, Vraka C, Godbersen GM, Unterholzner J, Sigurdardottir HL, Spies M, Seiger R, Kranz GS, Hahn A, Mitterhauser M, Wadsak W, Bauer A, Hacker M, Kasper S, Lanzenberger R. Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo. Cerebral Cortex 2018, 29: 372-382. PMID: 30357321, PMCID: PMC6294402, DOI: 10.1093/cercor/bhy249.Peer-Reviewed Original ResearchConceptsPositron emission tomographyEmission tomographySerotonin neurotransmitter systemSerotonin 1ACerebral cortexEnzyme monoamine oxidase AMonoamine oxidase ANeurotransmitter systemsSerotonin systemPsychotropic drugsNeuropsychiatric disordersBrain functionHealthy participantsSerotonin transporterMolecular imaging dataMolecular targetsMolecular profileOxidase AWhole-brain coverageCortexParcellationTomographyDefined clustersClose associationImaging data