2019
Association of norepinephrine transporter methylation with in vivo NET expression and hyperactivity–impulsivity symptoms in ADHD measured with PET
Sigurdardottir HL, Kranz GS, Rami-Mark C, James GM, Vanicek T, Gryglewski G, Berroterán-Infante N, Kautzky A, Hienert M, Traub-Weidinger T, Mitterhauser M, Wadsak W, Hartmann AM, Hacker M, Rujescu D, Kasper S, Lanzenberger R. Association of norepinephrine transporter methylation with in vivo NET expression and hyperactivity–impulsivity symptoms in ADHD measured with PET. Molecular Psychiatry 2019, 26: 1009-1018. PMID: 31383926, PMCID: PMC7910214, DOI: 10.1038/s41380-019-0461-x.Peer-Reviewed Original ResearchAdultAttention Deficit Disorder with HyperactivityBrainHumansImpulsive BehaviorNorepinephrine Plasma Membrane Transport ProteinsPositron-Emission Tomography
2015
Effects of norepinephrine transporter gene variants on NET binding in ADHD and healthy controls investigated by PET
Sigurdardottir HL, Kranz GS, Rami‐Mark C, James GM, Vanicek T, Gryglewski G, Kautzky A, Hienert M, Traub‐Weidinger T, Mitterhauser M, Wadsak W, Hacker M, Rujescu D, Kasper S, Lanzenberger R. Effects of norepinephrine transporter gene variants on NET binding in ADHD and healthy controls investigated by PET. Human Brain Mapping 2015, 37: 884-895. PMID: 26678348, PMCID: PMC4949568, DOI: 10.1002/hbm.23071.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttention Deficit Disorder with HyperactivityBrainBrain MappingCohort StudiesFemaleGenotyping TechniquesHumansLinkage DisequilibriumMaleMorpholinesNorepinephrine Plasma Membrane Transport ProteinsPolymorphism, Single NucleotidePositron-Emission TomographyPromoter Regions, GeneticRadiopharmaceuticalsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationConceptsAttention deficit hyperactivity disorderPositron emission tomographyHealthy controlsNorepinephrine transporterSingle nucleotide polymorphismsAllele carriersMajor alleleFunctional promoter single nucleotide polymorphismsMajor allele carriersMinor allele carriersPromoter single nucleotide polymorphismsNET geneSymptoms of hyperactivityTransporter gene variantsLinear mixed model analysisDeficit hyperactivity disorderAdult patientsGenotype-dependent differencesADHD treatmentMixed model analysisMALDI-TOF platformADHD patientsStrong genetic componentEmission tomographyBPND