Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding
Baldinger P, Kraus C, Rami-Mark C, Gryglewski G, Kranz GS, Haeusler D, Hahn A, Spies M, Wadsak W, Mitterhauser M, Rujescu D, Kasper S, Lanzenberger R. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage 2015, 111: 505-512. PMID: 25652393, DOI: 10.1016/j.neuroimage.2015.01.049.Peer-Reviewed Original ResearchConceptsPositron emission tomographySerotonin transporterSerotonin releaseRespective projection areasReuptake of serotoninExtracellular serotonin concentrationBilateral parahippocampal gyrusComplex receptor interactionsProtein expression levelsProjection areaSerotonin 1ASerotonergic transmissionSerotonergic effectsSerotonin concentrationsSerotonergic toneRaphe regionSerotonergic neurotransmissionWhole-brain ANOVAReceptor expressionSerotonergic systemSerotonin systemGenotype statusHealthy subjectsSerotonergic structuresParahippocampal gyrus