2015
Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding
Baldinger P, Kraus C, Rami-Mark C, Gryglewski G, Kranz GS, Haeusler D, Hahn A, Spies M, Wadsak W, Mitterhauser M, Rujescu D, Kasper S, Lanzenberger R. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage 2015, 111: 505-512. PMID: 25652393, DOI: 10.1016/j.neuroimage.2015.01.049.Peer-Reviewed Original ResearchConceptsPositron emission tomographySerotonin transporterSerotonin releaseRespective projection areasReuptake of serotoninExtracellular serotonin concentrationBilateral parahippocampal gyrusComplex receptor interactionsProtein expression levelsProjection areaSerotonin 1ASerotonergic transmissionSerotonergic effectsSerotonin concentrationsSerotonergic toneRaphe regionSerotonergic neurotransmissionWhole-brain ANOVAReceptor expressionSerotonergic systemSerotonin systemGenotype statusHealthy subjectsSerotonergic structuresParahippocampal gyrus
2014
High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People
Kranz GS, Wadsak W, Kaufmann U, Savli M, Baldinger P, Gryglewski G, Haeusler D, Spies M, Mitterhauser M, Kasper S, Lanzenberger R. High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People. Biological Psychiatry 2014, 78: 525-533. PMID: 25497691, PMCID: PMC4585531, DOI: 10.1016/j.biopsych.2014.09.010.Peer-Reviewed Original ResearchConceptsSerotonin reuptake transporterSERT bindingFemale transsexualsStart of treatmentSteroid hormone treatmentNew treatment modalitiesTreatment of depressionMedian raphe nucleusHormone plasma levelsTreatment-induced increaseMid-cingulate cortexPositron emission tomographyMechanism of actionTreatment startSerotonergic transmissionEstradiol levelsRaphe nucleusEstrogen treatmentReuptake transporterTreatment modalitiesAndrogen treatmentEpidemiologic findingsPlasma levelsSex hormonesSERT expression