How to prevent and manage hyperammonemic encephalopathies in valproate therapy
Mitschek M, Vanicek T, Unterholzner J, Kraus C, Weidenauer A, Naderi-Heiden A, Frey R, Silberbauer L, Gryglewski G, Papageorgiou K, Winkler D, Dold M, Kasper S, Praschak-Rieder N, Bartova L. How to prevent and manage hyperammonemic encephalopathies in valproate therapy. Journal Of Affective Disorders Reports 2021, 5: 100186. DOI: 10.1016/j.jadr.2021.100186.Peer-Reviewed Case Reports and Technical NotesSevere cognitive impairmentValproic acidHyperammonemic encephalopathyPlasma levelsCognitive impairmentPotential drug interactionsYoung male patientLife-threatening symptomsUrea cycle deficiencyUrea cycle defectsValproate therapyMale patientsCase seriesFemale patientsUrinary levelsComatose stateDrug interactionsIndividual patientsPsychotic episodePatientsAffective symptomsCurrent psychotic episodePsychiatric inpatientsPolypharmacyEncephalopathyMeta-analysis of brain structural changes after electroconvulsive therapy in depression
Gryglewski G, Lanzenberger R, Silberbauer LR, Pacher D, Kasper S, Rupprecht R, Frey R, Baldinger-Melich P. Meta-analysis of brain structural changes after electroconvulsive therapy in depression. Brain Stimulation 2021, 14: 927-937. PMID: 34119669, DOI: 10.1016/j.brs.2021.05.014.Peer-Reviewed Original ResearchConceptsElectroconvulsive therapyDentate gyrusHippocampal subfieldsSignificant volume increaseSeries of ECTStandardized mean change scoresBrain structuresLongitudinal magnetic resonance imagingBrain structural changesCornu ammonis 1Mean change scoresRegional brain volumesRandom-effects modelMagnetic resonance imagingClinical outcomesSymptom improvementDepressive patientsTreatment outcomesStandardized mean changeBilateral hippocampusIndividual patientsMean changeBrain volumeWarrant replicationResonance imaging