2022
Meta-analysis of molecular imaging of translocator protein in major depression
Eggerstorfer B, Kim JH, Cumming P, Lanzenberger R, Gryglewski G. Meta-analysis of molecular imaging of translocator protein in major depression. Frontiers In Molecular Neuroscience 2022, 15: 981442. PMID: 36226319, PMCID: PMC9549359, DOI: 10.3389/fnmol.2022.981442.Peer-Reviewed Original ResearchBody mass indexMajor depressive disorderMDD patientsMolecular imaging studiesTranslocator proteinImaging studiesTSPO availabilityPositron emission tomography studyMarkers of neuroinflammationSerotonin transporter availabilityEmission tomography studiesSystematic literature searchTime of scanningEffect sizeMolecular neuroimaging studiesMass indexDepressive disorderHealthy controlsMajor depressionTransporter availabilityHealthy subjectsTreatment statusDepression severityTemporal cortexBrain regions
2018
Striatal dopaminergic alterations in Tourette’s syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies
Hienert M, Gryglewski G, Stamenkovic M, Kasper S, Lanzenberger R. Striatal dopaminergic alterations in Tourette’s syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies. Translational Psychiatry 2018, 8: 143. PMID: 30072700, PMCID: PMC6072751, DOI: 10.1038/s41398-018-0202-y.Peer-Reviewed Original ResearchConceptsTourette patientsTourette syndromeDopamine transporterDopaminergic alterationsDopamine systemCurrent pathophysiological hypothesesStriatal dopaminergic alterationsStriatal dopamine receptorsStudy population characteristicsStriatal dopamine transporterStriatal dopamine functionFree patientsHealthy controlsPathophysiological hypothesesDopamine receptorsMolecular imaging studiesNonsignificant trendDopamine functionPatientsSPECT studiesSystematic reviewImaging studiesSyndromeNeuroimaging studiesReceptor binding
2014
Meta-Analysis of Molecular Imaging of Serotonin Transporters in Major Depression
Gryglewski G, Lanzenberger R, Kranz GS, Cumming P. Meta-Analysis of Molecular Imaging of Serotonin Transporters in Major Depression. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1096-1103. PMID: 24802331, PMCID: PMC4083395, DOI: 10.1038/jcbfm.2014.82.Peer-Reviewed Original ResearchConceptsMajor depressive disorderSerotonin selective reuptake inhibitorsBrains of patientsSeverity of depressionMolecular imaging findingsPositron emission tomographySerotonin reuptake sitesSingle photon emissionMore severe reductionsSignificant comorbiditiesReuptake inhibitorsImaging findingsMDD patientsControl subjectsMonoamine theoryReuptake sitesDepressive disorderSerotonergic neurotransmissionMajor depressionMolecular imaging studiesStudy populationCingulate cortexMeta-AnalysisEmission tomographyImaging studies