2020
Predicting Antidepressant Citalopram Treatment Response via Changes in Brain Functional Connectivity After Acute Intravenous Challenge
Klöbl M, Gryglewski G, Rischka L, Godbersen GM, Unterholzner J, Reed MB, Michenthaler P, Vanicek T, Winkler-Pjrek E, Hahn A, Kasper S, Lanzenberger R. Predicting Antidepressant Citalopram Treatment Response via Changes in Brain Functional Connectivity After Acute Intravenous Challenge. Frontiers In Computational Neuroscience 2020, 14: 554186. PMID: 33123000, PMCID: PMC7573155, DOI: 10.3389/fncom.2020.554186.Peer-Reviewed Original ResearchBeck Depression InventoryFunctional connectivitySymptom improvementMajor depressionDepression InventoryLong-term antidepressant effectsSelective serotonin reuptake inhibitorsHamilton Depression Rating ScaleResting-state functional magnetic resonanceAcute pharmacological challengeSerotonin reuptake inhibitorsWhole-brain functional connectivityCross-over fashionDepression Rating ScaleMajor depressive disorderHigher lifetime prevalenceBrain functional connectivityDefault mode networkHeterogeneity of responseFunctional magnetic resonanceEscitalopram therapyAntidepressant effectsReuptake inhibitorsStandard medicationIntravenous challenge
2017
Administration of ketamine for unipolar and bipolar depression
Kraus C, Rabl U, Vanicek T, Carlberg L, Popovic A, Spies M, Bartova L, Gryglewski G, Papageorgiou K, Lanzenberger R, Willeit M, Winkler D, Rybakowski JK, Kasper S. Administration of ketamine for unipolar and bipolar depression. International Journal Of Psychiatry In Clinical Practice 2017, 21: 2-12. PMID: 28097909, DOI: 10.1080/13651501.2016.1254802.Peer-Reviewed Original ResearchConceptsBipolar depressionSide effectsResponse rateMost common side effectsLong-term side effectsHamilton Depression Rating ScaleAntidepressant response ratesNausea/vomitingOpen-label trialRapid antidepressant efficacyTreatment-resistant depressionAnti-suicidal effectsCommon side effectsEfficacious treatment optionPrimary outcome measureAdministration of ketamineDepression Rating ScaleNew administration routesWeb of ScienceKetamine efficacyResistant depressionAntidepressant efficacyRelapse rateAntidepressant responseSafety profile