2021
Meta-analysis of brain structural changes after electroconvulsive therapy in depression
Gryglewski G, Lanzenberger R, Silberbauer LR, Pacher D, Kasper S, Rupprecht R, Frey R, Baldinger-Melich P. Meta-analysis of brain structural changes after electroconvulsive therapy in depression. Brain Stimulation 2021, 14: 927-937. PMID: 34119669, DOI: 10.1016/j.brs.2021.05.014.Peer-Reviewed Original ResearchConceptsElectroconvulsive therapyDentate gyrusHippocampal subfieldsSignificant volume increaseSeries of ECTStandardized mean change scoresBrain structuresLongitudinal magnetic resonance imagingBrain structural changesCornu ammonis 1Mean change scoresRegional brain volumesRandom-effects modelMagnetic resonance imagingClinical outcomesSymptom improvementDepressive patientsTreatment outcomesStandardized mean changeBilateral hippocampusIndividual patientsMean changeBrain volumeWarrant replicationResonance imaging
2018
Structural changes in amygdala nuclei, hippocampal subfields and cortical thickness following electroconvulsive therapy in treatment-resistant depression: longitudinal analysis
Gryglewski G, Baldinger-Melich P, Seiger R, Godbersen GM, Michenthaler P, Klöbl M, Spurny B, Kautzky A, Vanicek T, Kasper S, Frey R, Lanzenberger R. Structural changes in amygdala nuclei, hippocampal subfields and cortical thickness following electroconvulsive therapy in treatment-resistant depression: longitudinal analysis. The British Journal Of Psychiatry 2018, 214: 159-167. PMID: 30442205, PMCID: PMC6383756, DOI: 10.1192/bjp.2018.224.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionElectroconvulsive therapyMagnetic resonance imagingCortical thicknessHippocampal subfieldsAmygdala nucleiHippocampal-amygdaloid transition areaRight unilateral electroconvulsive therapyEffects of ECTHigh-resolution structural magnetic resonance imagingUnipolar treatment-resistant depressionCorticoamygdaloid transition areaPathophysiology of depressionPre-post study designCorrelation of imagingUnilateral electroconvulsive therapyTreatment of choiceStructural magnetic resonance imagingSpecific hippocampal subfieldsSevere mental illnessGrant/research supportStress-related disordersClinical parametersRepeated-measures ANOVADentate gyrus