2021
Meta-analysis of brain structural changes after electroconvulsive therapy in depression
Gryglewski G, Lanzenberger R, Silberbauer LR, Pacher D, Kasper S, Rupprecht R, Frey R, Baldinger-Melich P. Meta-analysis of brain structural changes after electroconvulsive therapy in depression. Brain Stimulation 2021, 14: 927-937. PMID: 34119669, DOI: 10.1016/j.brs.2021.05.014.Peer-Reviewed Original ResearchConceptsElectroconvulsive therapyDentate gyrusHippocampal subfieldsSignificant volume increaseSeries of ECTStandardized mean change scoresBrain structuresLongitudinal magnetic resonance imagingBrain structural changesCornu ammonis 1Mean change scoresRegional brain volumesRandom-effects modelMagnetic resonance imagingClinical outcomesSymptom improvementDepressive patientsTreatment outcomesStandardized mean changeBilateral hippocampusIndividual patientsMean changeBrain volumeWarrant replicationResonance imaging
2019
Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression
Gryglewski G, Seiger R, Baldinger-Melich P, Unterholzner J, Spurny B, Vanicek T, Hahn A, Kasper S, Frey R, Lanzenberger R. Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression. The International Journal Of Neuropsychopharmacology 2019, 23: 20-25. PMID: 31740958, PMCID: PMC7064047, DOI: 10.1093/ijnp/pyz059.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionElectroconvulsive therapyWhite matter microstructureRight unilateral electroconvulsive therapyDiffusivity metricsUnipolar treatment-resistant depressionPoor antidepressant responseEffective therapeutic optionUnilateral electroconvulsive therapyDiffusion tensor imaging sequencesElectrode placementTract-based spatial statisticsAntidepressant responseClinical outcomesTherapeutic optionsInternal capsuleRepeated-measures ANOVAPosterior limbTreatment responseMagnetic resonanceElectrical stimulationTherapyAxial diffusivityLeft hemisphereWarrants investigation
2017
Effects of Selective Serotonin Reuptake Inhibitors on Interregional Relation of Serotonin Transporter Availability in Major Depression
James GM, Baldinger-Melich P, Philippe C, Kranz GS, Vanicek T, Hahn A, Gryglewski G, Hienert M, Spies M, Traub-Weidinger T, Mitterhauser M, Wadsak W, Hacker M, Kasper S, Lanzenberger R. Effects of Selective Serotonin Reuptake Inhibitors on Interregional Relation of Serotonin Transporter Availability in Major Depression. Frontiers In Human Neuroscience 2017, 11: 48. PMID: 28220069, PMCID: PMC5292566, DOI: 10.3389/fnhum.2017.00048.Peer-Reviewed Original ResearchSelective serotonin reuptake inhibitorsPositron emission tomographySerotonin reuptake inhibitorsMajor depressive disorderHealthy controlsReuptake inhibitorsSerotonergic neurotransmissionBrain regionsState functional magnetic resonance imaging studySerotonin transporterMagnetic resonance imaging studyReuptake of serotoninSerotonin transporter availabilityResonance imaging studyFunctional magnetic resonance imaging studyAnterior cingulate cortexSSRI doseAntidepressant effectsAntidepressant treatmentClinical outcomesSSRI administrationMDD patientsDepressive disorderMajor depressionMDD pathophysiology