2021
Escitalopram modulates learning content-specific neuroplasticity of functional brain networks
Klöbl M, Seiger R, Vanicek T, Handschuh P, Reed MB, Spurny-Dworak B, Ritter V, Godbersen GM, Gryglewski G, Kraus C, Hahn A, Lanzenberger R. Escitalopram modulates learning content-specific neuroplasticity of functional brain networks. NeuroImage 2021, 247: 118829. PMID: 34923134, DOI: 10.1016/j.neuroimage.2021.118829.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexSelective serotonin reuptake inhibitorsPrefrontal cortexBroca's areaLingual gyrusFunctional connectivityFunctional magnetic resonance imagingResting-state functional magnetic resonance imagingFunctional brain networksBrain functional connectivityFear extinctionComplexity of learningSerotonin reuptake inhibitorsHuman neuroplasticityBrain networksMagnetic resonance imagingEscitalopram intakeComparable modulationClinical improvementSSRI escitalopramDaily doseReuptake inhibitorsNeuroplastic changesHealthy subjectsNeuroplasticity
2020
Predicting Antidepressant Citalopram Treatment Response via Changes in Brain Functional Connectivity After Acute Intravenous Challenge
Klöbl M, Gryglewski G, Rischka L, Godbersen GM, Unterholzner J, Reed MB, Michenthaler P, Vanicek T, Winkler-Pjrek E, Hahn A, Kasper S, Lanzenberger R. Predicting Antidepressant Citalopram Treatment Response via Changes in Brain Functional Connectivity After Acute Intravenous Challenge. Frontiers In Computational Neuroscience 2020, 14: 554186. PMID: 33123000, PMCID: PMC7573155, DOI: 10.3389/fncom.2020.554186.Peer-Reviewed Original ResearchBeck Depression InventoryFunctional connectivitySymptom improvementMajor depressionDepression InventoryLong-term antidepressant effectsSelective serotonin reuptake inhibitorsHamilton Depression Rating ScaleResting-state functional magnetic resonanceAcute pharmacological challengeSerotonin reuptake inhibitorsWhole-brain functional connectivityCross-over fashionDepression Rating ScaleMajor depressive disorderHigher lifetime prevalenceBrain functional connectivityDefault mode networkHeterogeneity of responseFunctional magnetic resonanceEscitalopram therapyAntidepressant effectsReuptake inhibitorsStandard medicationIntravenous challenge