2022
Increased left dorsolateral prefrontal cortex density following escitalopram intake during relearning: a randomized, placebo-controlled trial in healthy humans
Vanicek T, Reed M, Seiger R, Godbersen G, Klöbl M, Unterholzner J, Spurny-Dworak B, Gryglewski G, Handschuh P, Schmidt C, Kraus C, Stimpfl T, Rupprecht R, Kasper S, Lanzenberger R. Increased left dorsolateral prefrontal cortex density following escitalopram intake during relearning: a randomized, placebo-controlled trial in healthy humans. Therapeutic Advances In Psychopharmacology 2022, 12: 20451253221132085. PMID: 36420117, PMCID: PMC9677158, DOI: 10.1177/20451253221132085.Peer-Reviewed Original ResearchLeft dorsolateral prefrontal cortexAssociative learning taskNon-emotional contentDorsolateral prefrontal cortexVoxel-based morphometry analysisEmotional processingExecutive functionLearning taskNeurobiological processesVoxel-based morphometryPrefrontal cortexBrain plasticityEscitalopram intakeNeural plasticityBrain areasNeuroplastic processesBlood levelsBrain structuresHealthy individualsMorphometry analysisDouble-blind placebo controlGray matterStress-induced dendritic atrophySelective serotonin reuptake inhibitorsPlacebo intake
2021
Comparison and Reliability of Hippocampal Subfield Segmentations Within FreeSurfer Utilizing T1- and T2-Weighted Multispectral MRI Data
Seiger R, Hammerle FP, Godbersen GM, Reed MB, Spurny-Dworak B, Handschuh P, Klöbl M, Unterholzner J, Gryglewski G, Vanicek T, Lanzenberger R. Comparison and Reliability of Hippocampal Subfield Segmentations Within FreeSurfer Utilizing T1- and T2-Weighted Multispectral MRI Data. Frontiers In Neuroscience 2021, 15: 666000. PMID: 34602964, PMCID: PMC8480394, DOI: 10.3389/fnins.2021.666000.Peer-Reviewed Original ResearchHigh-resolution T2-weighted sequencesProcessing pipelineT2-weighted sequencesAccurate segmentationMultispectral informationMultispectral MRI dataPutative imaging biomarkersDifferent processing pipelinesStructural MRI sequencesT1-weighted sequencesTest-retest variabilityDifferent input configurationsCross-sectional mannerInput imageSegmentation resultsDisease progressionMagnetic resonance imaging dataHippocampal fissureHippocampal formationHippocampal subfieldsHippocampal subfield segmentationPatient stratificationBrain areasPsychiatric diseasesDice coefficient