Predicting Antidepressant Citalopram Treatment Response via Changes in Brain Functional Connectivity After Acute Intravenous Challenge
Klöbl M, Gryglewski G, Rischka L, Godbersen GM, Unterholzner J, Reed MB, Michenthaler P, Vanicek T, Winkler-Pjrek E, Hahn A, Kasper S, Lanzenberger R. Predicting Antidepressant Citalopram Treatment Response via Changes in Brain Functional Connectivity After Acute Intravenous Challenge. Frontiers In Computational Neuroscience 2020, 14: 554186. PMID: 33123000, PMCID: PMC7573155, DOI: 10.3389/fncom.2020.554186.Peer-Reviewed Original ResearchBeck Depression InventoryFunctional connectivitySymptom improvementMajor depressionDepression InventoryLong-term antidepressant effectsSelective serotonin reuptake inhibitorsHamilton Depression Rating ScaleResting-state functional magnetic resonanceAcute pharmacological challengeSerotonin reuptake inhibitorsWhole-brain functional connectivityCross-over fashionDepression Rating ScaleMajor depressive disorderHigher lifetime prevalenceBrain functional connectivityDefault mode networkHeterogeneity of responseFunctional magnetic resonanceEscitalopram therapyAntidepressant effectsReuptake inhibitorsStandard medicationIntravenous challenge