2019
Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression
Gryglewski G, Seiger R, Baldinger-Melich P, Unterholzner J, Spurny B, Vanicek T, Hahn A, Kasper S, Frey R, Lanzenberger R. Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression. The International Journal Of Neuropsychopharmacology 2019, 23: 20-25. PMID: 31740958, PMCID: PMC7064047, DOI: 10.1093/ijnp/pyz059.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionElectroconvulsive therapyWhite matter microstructureRight unilateral electroconvulsive therapyDiffusivity metricsUnipolar treatment-resistant depressionPoor antidepressant responseEffective therapeutic optionUnilateral electroconvulsive therapyDiffusion tensor imaging sequencesElectrode placementTract-based spatial statisticsAntidepressant responseClinical outcomesTherapeutic optionsInternal capsuleRepeated-measures ANOVAPosterior limbTreatment responseMagnetic resonanceElectrical stimulationTherapyAxial diffusivityLeft hemisphereWarrants investigation
2017
Administration of ketamine for unipolar and bipolar depression
Kraus C, Rabl U, Vanicek T, Carlberg L, Popovic A, Spies M, Bartova L, Gryglewski G, Papageorgiou K, Lanzenberger R, Willeit M, Winkler D, Rybakowski JK, Kasper S. Administration of ketamine for unipolar and bipolar depression. International Journal Of Psychiatry In Clinical Practice 2017, 21: 2-12. PMID: 28097909, DOI: 10.1080/13651501.2016.1254802.Peer-Reviewed Original ResearchConceptsBipolar depressionSide effectsResponse rateMost common side effectsLong-term side effectsHamilton Depression Rating ScaleAntidepressant response ratesNausea/vomitingOpen-label trialRapid antidepressant efficacyTreatment-resistant depressionAnti-suicidal effectsCommon side effectsEfficacious treatment optionPrimary outcome measureAdministration of ketamineDepression Rating ScaleNew administration routesWeb of ScienceKetamine efficacyResistant depressionAntidepressant efficacyRelapse rateAntidepressant responseSafety profile