2022
Correlation of receptor density and mRNA expression patterns in the human cerebral cortex
Murgaš M, Michenthaler P, Reed MB, Gryglewski G, Lanzenberger R. Correlation of receptor density and mRNA expression patterns in the human cerebral cortex. NeuroImage 2022, 256: 119214. PMID: 35452805, DOI: 10.1016/j.neuroimage.2022.119214.Peer-Reviewed Original ResearchConceptsMRNA expression patternsExpression patternsPost-translational processesGene expression patternsRNA sequencing dataComprehensive proteomic studyMolecular targetsMulti-receptor systemsMessenger ribonucleic acid transcriptsRibonucleic acid transcriptsTranscriptome dataProteomic informationProteomic dataProteomic studiesMost proteinsSequencing dataVivo linkMicroarray dataAllen Human Brain AtlasMRNA expressionProtein densitySubunits α3ProteinHuman Brain AtlasHigh-resolution topology
2021
Differential patterns of gray matter volumes and associated gene expression profiles in cognitively-defined Alzheimer’s disease subgroups
Groot C, Grothe MJ, Mukherjee S, Jelistratova I, Jansen I, van Loenhoud AC, Risacher SL, Saykin AJ, Mac Donald C, Mez J, Trittschuh EH, Gryglewski G, Lanzenberger R, Pijnenburg YAL, Barkhof F, Scheltens P, van der Flier WM, Crane PK, Ossenkoppele R. Differential patterns of gray matter volumes and associated gene expression profiles in cognitively-defined Alzheimer’s disease subgroups. NeuroImage Clinical 2021, 30: 102660. PMID: 33895633, PMCID: PMC8186562, DOI: 10.1016/j.nicl.2021.102660.Peer-Reviewed Original ResearchConceptsGray matter volumeRegional GM volumeAd memoryAd executivesGM volumeMatter volumeRegional gray matter volumeVoxel-wise contrastsAlzheimer’s disease subgroupsCognitive domainsCognitive profileNeuropsychological assessmentNeurobiological mechanismsNeurobiological differencesPsychometric frameworkAd languageRelative impairmentTemporal lobeHuman brainAllen Human Brain AtlasDifferential patternsStructural MRILower GM volumeHuman Brain AtlasPosterior areas