1984
The clinical spectrum and treatment of Lyme disease.
Steere A, Malawista S, Bartenhagen N, Spieler P, Newman J, Rahn D, Hutchinson G, Green J, Snydman D, Taylor E. The clinical spectrum and treatment of Lyme disease. The Yale Journal Of Biology And Medicine 1984, 57: 453-61. PMID: 6516448, PMCID: PMC2590003.Peer-Reviewed Original ResearchMeSH KeywordsAcrodermatitisAnti-Bacterial AgentsBites and StingsDiagnosis, DifferentialEdemaHumansLyme DiseasePrognosisTicksConceptsLyme diseaseHigh-dose intravenous penicillinJuvenile rheumatoid arthritisEarly Lyme diseaseErosion of cartilageErythema chronicum migransB-cell alloantigensIntravenous penicillinRheumatoid arthritisClinical spectrumProlonged illnessMultisystem disorderCardiac abnormalitiesIntermittent attacksEffective drugsPatientsDiseaseArthritisIllnessWeeksPenicillinSeparate entitiesGeographic clusteringAlloantigensLater stages
1983
The early clinical manifestations of Lyme disease.
Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Rahn DW, Sigal LH, Spieler PN, Stenn KS, Malawista SE. The early clinical manifestations of Lyme disease. Annals Of Internal Medicine 1983, 99: 76-82. PMID: 6859726, DOI: 10.7326/0003-4819-99-1-76.Peer-Reviewed Original ResearchConceptsLyme diseaseSkin lesionsElevated serum IgM levelsMigratory musculoskeletal painTick-transmitted spirochetesUnique skin lesionAspartate transaminase levelsEarly clinical manifestationsEarly Lyme diseaseSerum IgM levelsErythema chronicum migransMeningeal irritationLaboratory abnormalitiesNonproductive coughTransaminase levelsUrticarial rashMusculoskeletal painRegional lymphadenopathySkin manifestationsSore throatDermatologic manifestationsSerologic testingClinical manifestationsIgM levelsPeriorbital edema