2011
Downregulation of Filamin A Interacting Protein 1-Like is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer
Burton ER, Gaffar A, Lee SJ, Adeshuko F, Whitney KD, Chung JY, Hewitt SM, Huang GS, Goldberg GL, Libutti SK, Kwon M. Downregulation of Filamin A Interacting Protein 1-Like is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer. Molecular Cancer Research 2011, 9: 1126-1138. PMID: 21693594, PMCID: PMC3157597, DOI: 10.1158/1541-7786.mcr-11-0162.Peer-Reviewed Original ResearchMeSH KeywordsCarrier ProteinsCell LineCell Line, TumorCell MovementCell ProliferationCpG IslandsCyclic AMP Response Element-Binding ProteinCytoskeletal ProteinsDNA MethylationFemaleGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessNeoplasm StagingOvarian NeoplasmsPhenotypePromoter Regions, GeneticConceptsOvarian cancer cellsFILIP1L expressionOvarian cancerCAMP-responsive element binding proteinCancer cellsClinical ovarian cancer specimensFive-year survival rateMore effective therapeutic interventionsInvasive phenotypeLethal gynecologic malignancyOvarian cancer cell linesNormal ovarian epithelial cellsOvarian cancer specimensOvarian cancer invasionOvarian cancer therapyEffective therapeutic interventionsCell linesOvarian epithelial cellsOvarian cell linesCancer cell linesGynecologic malignanciesOvarian specimensCancer specimensStage IIIDNA demethylating agent
2007
Serum CA125 predicts extrauterine disease and survival in uterine carcinosarcoma
Huang GS, Chiu LG, Gebb JS, Gunter MJ, Sukumvanich P, Goldberg GL, Einstein MH. Serum CA125 predicts extrauterine disease and survival in uterine carcinosarcoma. Gynecologic Oncology 2007, 107: 513-517. PMID: 17935762, PMCID: PMC2696225, DOI: 10.1016/j.ygyno.2007.08.060.Peer-Reviewed Original ResearchConceptsDeep myometrial invasionCA125 elevationExtrauterine diseasePrognostic factorsUterine carcinosarcomaPreoperative CA125CA125 levelsCA125 measurementMyometrial invasionPoor survivalExact testCox proportional hazards modelClinicopathologic prognostic factorsEstrogen receptor positivityIndependent prognostic factorManagement of patientsUnivariate survival analysisUseful serum markerPearson's chi-square testProportional hazards modelFisher's exact testChi-square testSerous histologyConsecutive patientsReceptor positivity