2009
Successful Integration of Tuberculosis and HIV Treatment in Rural South Africa: The Sizonq'oba Study
Gandhi NR, Moll AP, Lalloo U, Pawinski R, Zeller K, Moodley P, Meyer E, Friedland G. Successful Integration of Tuberculosis and HIV Treatment in Rural South Africa: The Sizonq'oba Study. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2009, 50: 37-43. PMID: 19295333, DOI: 10.1097/qai.0b013e31818ce6c4.Peer-Reviewed Original ResearchConceptsTB/HIV-coinfected patientsHIV treatmentCubic millimeterCD4 count increaseDaily antiretroviral therapyImmune reconstitution eventsIntegration of tuberculosisMedian CD4 countUndetectable viral loadSevere adverse eventsDrug-resistant tuberculosisRural resource-poor settingsCause of deathHome-based therapyResource-poor settingsRural KwaZulu-NatalARV dosesTreatment defaultAntiretroviral therapyCD4 countHIV careOperational research studyTB patientsAdverse eventsObserved therapy
2004
A Pilot Study of Once-Daily Antiretroviral Therapy Integrated With Tuberculosis Directly Observed Therapy in a Resource-Limited Setting
Jack C, Lalloo U, Karim QA, Karim SA, El-Sadr W, Cassol S, Friedland G. A Pilot Study of Once-Daily Antiretroviral Therapy Integrated With Tuberculosis Directly Observed Therapy in a Resource-Limited Setting. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2004, 36: 929-934. PMID: 15220699, DOI: 10.1097/00126334-200408010-00006.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdolescentAdultAlkynesAnti-HIV AgentsAntibiotics, AntitubercularAntiretroviral Therapy, Highly ActiveBenzoxazinesCosts and Cost AnalysisCyclopropanesDidanosineDrug Therapy, CombinationFemaleHIV InfectionsHumansLamivudineMaleMiddle AgedOutpatient Clinics, HospitalOxazinesPilot ProjectsSouth AfricaTreatment OutcomeTuberculosisUrban PopulationConceptsAntiretroviral therapyTB therapyViral loadPilot studyTwenty HIV-positive patientsSmear-positive pulmonary TBCD4 count increaseDrug-sensitive TBObserved therapy programStandard TB therapyActive antiretroviral therapyHIV-positive patientsMean CD4 countMean viral loadCells/Resource limited settingsResource-limited settingsDaily didanosineHAART regimenCD4 countHIV clinicPulmonary TBTB clinicNeurologic toxicityObserved therapy