2024
Stiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodelingIntimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis
Hassab A, Hur D, Vallabhajosyula P, Tellides G, Assi R. Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis. JCI Insight 2024, 9: e172437. PMID: 38592807, PMCID: PMC11141924, DOI: 10.1172/jci.insight.172437.Peer-Reviewed Original ResearchConceptsDepartment of SurgerySmooth muscle cellsCellular response to injuryResponse to injuryImmunofluorescence confocal microscopyVessel wall repairPrimary lesionAscending aortaConduit functionAneurysmal diseaseDense fibrosisRadiological signsMural hematomaTear progressionMuscle cellsNon-hemorrhagicErythrocyte extravasationWall repairAortaTear completionInduce atherosclerosisHealed lesionsScattered leukocytesMinimal injuryConclusionThese findings
2021
Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis
Zhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, Fernández-Hernando C. Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2107682118. PMID: 34782454, PMCID: PMC8617522, DOI: 10.1073/pnas.2107682118.Peer-Reviewed Original ResearchConceptsCholesterol biosynthetic intermediatesBiosynthetic intermediatesDependent inflammasome activationSingle-cell transcriptomicsMitochondrial reactive oxygen species productionFoam cell formationMacrophage foam cellsReactive oxygen species productionHuman coronary artery lesionsConversion of desmosterolTranscriptomic analysisMacrophage cholesterol metabolismPhysiological contextOxygen species productionLiver X receptor ligandsApoptosis-associated speck-like proteinRetinoid X receptor activationX receptor ligandsInflammasome activationAtherosclerotic plaquesSpeck-like proteinCholesterol homeostasisMacrophage inflammasome activationKey moleculesCell formation
2001
Single-clamp technique does not protect against cerebrovascular accident in coronary artery bypass grafting⋆
Kim R, Mariconda D, Tellides G, Kopf G, Dewar M, Lin Z, Elefteriades J. Single-clamp technique does not protect against cerebrovascular accident in coronary artery bypass grafting⋆. European Journal Of Cardio-Thoracic Surgery 2001, 20: 127-132. PMID: 11423285, DOI: 10.1016/s1010-7940(01)00765-5.Peer-Reviewed Original ResearchConceptsSingle-clamp techniqueCoronary artery bypassPostoperative strokeArtery bypassStroke preventionCerebrovascular accidentSide-biting aortic clampAdverse myocardial effectsCross-clamp timePostoperative adverse eventsPerioperative myocardial infarctionCoronary bypass operationsLogistic regression analysisEmbolic consequencesHospital mortalityAdverse eventsAortic clampMyocardial effectsBypass operationMyocardial infarctionMyocardial protectionClinical practiceClamp techniqueSecond surgeonStroke
2000
Effect of left ventricular volume on results of coronary artery bypass grafting
Kim R, Ugurlu B, Tereb D, Wackers F, Tellides G, Elefteriades J. Effect of left ventricular volume on results of coronary artery bypass grafting. The American Journal Of Cardiology 2000, 86: 1261-1264. PMID: 11090805, DOI: 10.1016/s0002-9149(00)01216-9.Peer-Reviewed Original ResearchConceptsCoronary artery bypassArtery bypassSignificant left ventricular dilationLeft ventricular dilationLV chamber sizeLV ejection fractionMedium-term survivalSurgical revascularizationAngina symptomsEjection fractionIschemic cardiomyopathyLV dilationVentricular dilationVentricular sizeVentricular volumePatientsSignificant reductionBypassChamber sizeDilationRevascularizationCardiomyopathySymptoms
1998
Pathogenesis of Systemic Air Embolism During Bronchoscopic Nd:YAG Laser Operations
Tellides G, Ugurlu B, Kim R, Hammond G. Pathogenesis of Systemic Air Embolism During Bronchoscopic Nd:YAG Laser Operations. The Annals Of Thoracic Surgery 1998, 65: 930-934. PMID: 9564904, DOI: 10.1016/s0003-4975(98)00109-x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAirAluminum SilicatesAortic DiseasesBronchial NeoplasmsBronchoscopyEchocardiography, TransesophagealElectrocardiographyEmbolism, AirEndoscopyEquipment DesignFemaleHeart DiseasesHumansHypotensionIntracranial Embolism and ThrombosisLaser TherapyLung NeoplasmsMaleMiddle AgedMonitoring, IntraoperativeMyocardial IschemiaNeodymiumSafetyUltrasonography, InterventionalYttriumConceptsSystemic air embolismAir embolismSystemic air emboliIschemic electrocardiographic changesLaser tumor ablationNeurologic complicationsCatastrophic complicationThird patientElectrocardiographic changesTransesophageal echocardiographyAir emboliEmbolismTumor ablationComplicationsPatientsSafety recommendationsBronchoscopic NdLaser fiberHypotensionEchocardiographyEmboliEmbolicPathogenesisShould Angiographically Disease-Free Saphenous Vein Grafts Be Replaced at the Time of Redo Coronary Artery Bypass Grafting?
Mehta I, Weinberg J, Jones M, Tellides G, Kopf G, Shaw R, Zaret B, Elefteriades J. Should Angiographically Disease-Free Saphenous Vein Grafts Be Replaced at the Time of Redo Coronary Artery Bypass Grafting? The Annals Of Thoracic Surgery 1998, 65: 17-23. PMID: 9456088, DOI: 10.1016/s0003-4975(97)01192-2.Peer-Reviewed Original ResearchConceptsSaphenous vein graftsVein graftsRedo CABGDisease-free graftsNR groupRedo Coronary Artery Bypass GraftingR groupCoronary Artery Bypass GraftingRedo coronary artery bypassGood late survivalArtery Bypass GraftingCoronary artery bypassLate myocardial infarctionFirst CABGRecurrent anginaRedo revascularizationArtery bypassBypass GraftingOperative mortalitySurgical mortalityAngiographic evaluationCardiac hospitalizationConsecutive patientsNew stenosisRandomized study
1994
Retrosternal ileocolic esophageal replacement in children revisited Antireflux role of the ileocecal valve
Touloukian R, Tellides G. Retrosternal ileocolic esophageal replacement in children revisited Antireflux role of the ileocecal valve. Journal Of Thoracic And Cardiovascular Surgery 1994, 107: 1067-1072. PMID: 8159028, DOI: 10.1016/s0022-5223(94)70382-5.Peer-Reviewed Original ResearchConceptsIleocecal valveEsophageal replacementEsophageal atresiaGastric tube interpositionSymptomatic gastroesophageal refluxPostoperative respiratory complicationsMonths of ageIleocolic interpositionOperative deathsGastroesophageal refluxPulmonary aspirationRespiratory complicationsAnastomotic leakPostoperative refluxPrimary anastomosisBarium swallowPediatric patientsGastrostomy tubeRegular dietPatientsRefluxAtresiaStrictureColonInterposition