2019
Paraspinous muscle gene expression profiling following simulated staged endovascular repair of thoracoabdominal aortic aneurysm: exploring potential therapeutic pathways
Lewis ER, Geisbüsch S, Chang YJ, Costa V, Husain S, Soteropoulos P, Griepp RB, Di Luozzo G. Paraspinous muscle gene expression profiling following simulated staged endovascular repair of thoracoabdominal aortic aneurysm: exploring potential therapeutic pathways. European Journal Of Cardio-Thoracic Surgery 2019, 57: 30-38. PMID: 31006003, DOI: 10.1093/ejcts/ezz113.Peer-Reviewed Original ResearchConceptsAneurysm repairGene expression profilingCollateral networkThoracoabdominal aortic aneurysm repairSpinal collateral networkSpinal segmental arteriesSuch extensive proceduresThoracoabdominal aortic aneurysmsAortic aneurysm repairSpinal cord perfusionSpinal cord injuryPotential therapeutic pathwayExpression profilingArteriolar remodellingTAAA repairCord perfusionNeurological complicationsEndovascular repairNeuroprotective effectsEndovascular techniquesCord injuryAortic aneurysmCoil embolizationEndovascular coilingEndovascular intervention
2013
Endovascular coil embolization of segmental arteries prevents paraplegia after subsequent thoracoabdominal aneurysm repair: An experimental model
Geisbüsch S, Stefanovic A, Koruth JS, Lin HM, Morgello S, Weisz DJ, Griepp RB, Di Luozzo G. Endovascular coil embolization of segmental arteries prevents paraplegia after subsequent thoracoabdominal aneurysm repair: An experimental model. Journal Of Thoracic And Cardiovascular Surgery 2013, 147: 220-227. PMID: 24220154, PMCID: PMC3918675, DOI: 10.1016/j.jtcvs.2013.09.022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationEmbolization, TherapeuticEndovascular ProceduresHindlimbLumbosacral RegionModels, AnimalMuscle, SkeletalParaplegiaRecovery of FunctionRegional Blood FlowSpinal Cord IschemiaSwineThoracic ArteriesTime FactorsVideo RecordingConceptsSpinal cord injuryThoracoabdominal aneurysm repairHind limb functionSegmental arteriesTAAA repairAneurysm repairCord injuryGroup 2Tarlov scoreLimb functionCoil embolizationExperimental modelSpinal cordGroup 1Ischemic spinal cord injuryPostoperative spinal cord injuryHybrid TAAA repairJuvenile Yorkshire pigsLumbar segmental arteriesModified Tarlov scoreEndovascular coil embolizationLower thoracic/upper lumbar regionUpper lumbar regionPrevents paraplegiaHistopathologic injuryHypothermia for aortic surgery
Griepp RB, Di Luozzo G. Hypothermia for aortic surgery. Journal Of Thoracic And Cardiovascular Surgery 2013, 145: s56-s58. PMID: 23410782, DOI: 10.1016/j.jtcvs.2012.11.072.Peer-Reviewed Original ResearchConceptsHypothermic circulatory arrestCirculatory arrestAcceptable neurologic outcomesAortic arch repairThoracoabdominal aortic aneurysmsAortic surgeryNeurologic outcomeArch repairSurgical patientsBrain metabolismOrgan protectionAortic aneurysmDeep hypothermiaClinical practicePig modelRoutine useHypothermiaArrestRepairPatientsSurgeryAneurysmsPerfusion
2012
Imaging of vascular remodeling after simulated thoracoabdominal aneurysm repair
Geisbüsch S, Schray D, Bischoff MS, Lin HM, Griepp RB, Di Luozzo G. Imaging of vascular remodeling after simulated thoracoabdominal aneurysm repair. Journal Of Thoracic And Cardiovascular Surgery 2012, 144: 1471-1478. PMID: 23010582, PMCID: PMC3496032, DOI: 10.1016/j.jtcvs.2012.08.062.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortic Aneurysm, ThoracicArteriesBarium SulfateBehavior, AnimalCollateral CirculationContrast MediaDilatation, PathologicDisease Models, AnimalFemaleLatexLigationMammary ArteriesMultidetector Computed TomographyNeovascularization, PhysiologicParaplegiaReplica TechniquesSpinal CordSpinal Cord IschemiaSwineTime FactorsVascular Surgical ProceduresConceptsAnterior spinal arterySpinal cord blood supplySmall collateral vesselsAneurysm repairCollateral vesselsBlood supplyJuvenile Yorkshire pigsRisk of paraplegiaThoracoabdominal aneurysm repairThoracoabdominal aortic aneurysmsSpinal cord circulationEndovascular repairSpinal arteryArtery sacrificeIntercostal arteriesCord circulationInternal thoracicAortic aneurysmTomographic scanTomographic scanningVascular remodelingGroup 2Group 1Group 3Previous interventions
2011
Staged Approach Prevents Spinal Cord Injury in Hybrid Surgical-Endovascular Thoracoabdominal Aortic Aneurysm Repair: An Experimental Model
Bischoff MS, Scheumann J, Brenner RM, Ladage D, Bodian CA, Kleinman G, Ellozy SH, Di Luozzo G, Etz CD, Griepp RB. Staged Approach Prevents Spinal Cord Injury in Hybrid Surgical-Endovascular Thoracoabdominal Aortic Aneurysm Repair: An Experimental Model. The Annals Of Thoracic Surgery 2011, 92: 138-146. PMID: 21718839, DOI: 10.1016/j.athoracsur.2011.03.098.Peer-Reviewed Original ResearchMeSH KeywordsAngiographyAngioplastyAnimalsAortic Aneurysm, ThoracicCombined Modality TherapyDisease Models, AnimalFemaleFollow-Up StudiesIntraoperative ComplicationsMonitoring, IntraoperativeRandom AllocationRisk AssessmentSpinal CordSpinal Cord InjuriesStentsSurvival RateSwineTreatment OutcomeVascular Surgical ProceduresConceptsGroup 1Group 2Thoracoabdominal aortic aneurysm repairJuvenile Yorkshire pigsSevere ischemic damageHind limb functionAortic aneurysm repairStent graft occlusionLumbar spinal cordModified Tarlov scoreSpinal cord injuryEndovascular coverageTarlov scoreGraft occlusionAneurysm repairArtery ligationIntercostal arteriesIschemic damageCord injuryLimb functionSudden occlusionSpinal cordLower thoracicHistopathologic analysisPorcine modelSpinal Cord Preservation in Thoracoabdominal Aneurysm Repair
Bischoff MS, Di Luozzo G, Griepp EB, Griepp RB. Spinal Cord Preservation in Thoracoabdominal Aneurysm Repair. Perspectives In Vascular Surgery And Endovascular Therapy 2011, 23: 214-222. PMID: 21502113, DOI: 10.1177/1531003511400622.Peer-Reviewed Original ResearchConceptsSpinal cord injuryThoracoabdominal aneurysm repairAneurysm repairIncidence of paraplegiaSpinal cord preservationSpinal cord protectionEndovascular aortic repairOpen surgical repairSpinal cord vasculatureAortic repairEndovascular approachSurgical repairDreadful complicationCord injuryEndovascular proceduresCollateral networkInvasive natureRepairRecent technical advancementsParaparesisComplicationsParaplegiaInjuryIncidenceVasculature
2010
Measuring the collateral network pressure to minimize paraplegia risk in thoracoabdominal aneurysm resection
Etz CD, Zoli S, Bischoff MS, Bodian C, Di Luozzo G, Griepp RB. Measuring the collateral network pressure to minimize paraplegia risk in thoracoabdominal aneurysm resection. Journal Of Thoracic And Cardiovascular Surgery 2010, 140: s125-s130. PMID: 21092778, DOI: 10.1016/j.jtcvs.2010.07.040.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortic Aneurysm, ThoracicBlood PressureBlood Pressure DeterminationCatheterization, PeripheralCentral Venous PressureCerebrospinal Fluid PressureCollateral CirculationDisease Models, AnimalHumansParaplegiaRisk AssessmentRisk FactorsSpinal CordSwineTime FactorsVascular Surgical ProceduresConceptsMean aortic pressureSpinal cord injurySegmental arteriesCord injuryAortic pressureSpinal cord perfusion pressureThoracoabdominal aortic aneurysm repairThoracoabdominal aneurysm resectionSpinal cord perfusionAortic aneurysm repairAneurysm resectionParaplegia riskDistal bypassCord perfusionHypogastric arteryAneurysm repairPerfusion pressureArterial ligationEpidural spaceCollateral networkParavertebral musclesPulsatile perfusionArteryOutflow pressureInjuryExperimental Two-Stage Simulated Repair of Extensive Thoracoabdominal Aneurysms Reduces Paraplegia Risk
Zoli S, Etz CD, Roder F, Brenner RM, Bodian CA, Kleinman G, Di Luozzo G, Griepp RB. Experimental Two-Stage Simulated Repair of Extensive Thoracoabdominal Aneurysms Reduces Paraplegia Risk. The Annals Of Thoracic Surgery 2010, 90: 722-729. PMID: 20732484, DOI: 10.1016/j.athoracsur.2010.04.047.Peer-Reviewed Original ResearchConceptsSpinal cord perfusion pressureHind limb functionGroup 2Artery sacrificeLimb functionExtensive segmental artery sacrificeExtensive thoracoabdominal aneurysmsJuvenile Yorkshire pigsSevere ischemic damageMotor-evoked potentialsLumbar spinal cordSpinal cord functionModified Tarlov scoreSpinal cord injuryParaplegia riskTarlov scoreThoracoabdominal aneurysmsAneurysm repairCord functionDistal stumpIschemic damagePerfusion pressureCord injurySpinal cordLower thoracic
2005
Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration
Di Luozzo G, Pradhan S, Dhadwal AK, Chen A, Ueno H, Sumpio BE. Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration. Atherosclerosis 2005, 178: 271-277. PMID: 15694934, DOI: 10.1016/j.atherosclerosis.2004.09.017.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cell migrationSmooth muscle cell migrationMuscle cell migrationInhibitors of p38VSMC migrationMitogen-activated protein kinaseEndothelial cellsDevelopment of atherosclerosisEffects of nicotineCell migrationWestern blotting methodInjury modelVascular endotheliumCigarette smokeBoyden chamber chemotaxis assaysAortic VSMCsChemotactic effectMAPKs p38NicotineChemoattractant moleculesChemotaxis assaysCellular mechanismsUltrastructural changesVSMCP44/42 activation
2000
Vascular smooth muscle cell effect on endothelial cell endothelin-1 production
Di Luozzo G, Bhargava J, Powell R. Vascular smooth muscle cell effect on endothelial cell endothelin-1 production. Journal Of Vascular Surgery 2000, 31: 781-789. PMID: 10753286, DOI: 10.1067/mva.2000.103788.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsET-1 productionEndothelin-1SMC proliferationEndothelial cellsNitro-L-arginine methyl esterNitric oxide synthase activityEC stimulationEndothelin-1 productionVascular lesion developmentNO synthase inhibitorOxide synthase activityEffects of SMCEts-1 proteinReceptor blockersCo-culture modelSMC inhibitionSynthase inhibitorLesion developmentB receptorMuscle cellsPotent mitogenRNA levelsProtein levelsPutative factors