2001
The Integrin-Mediated Cyclic Strain-Induced Signaling Pathway in Vascular Endothelial Cells
Frangos S, Knox R, Yano Y, Chen E, Di Luozzo G, Chen A, Sumpio B. The Integrin-Mediated Cyclic Strain-Induced Signaling Pathway in Vascular Endothelial Cells. Endothelium 2001, 8: 1-10. PMID: 11409847, DOI: 10.3109/10623320109063153.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinase (MAPK) familyCytoplasmic protein kinaseProtein kinase familySignal transduction pathwaysFocal adhesion kinaseExtracellular matrix receptorsProcess of phosphorylationEndothelial cellsKinase familySignal transductionTranscription factorsAdhesion kinaseProtein kinaseTransduction pathwaysMatrix receptorsGene expressionTyrosine residuesSignaling pathwaysCyclic circumferential strainVascular endothelial cellsPathwayKinaseIntegrinsHemodynamic forcesVasculature results
2000
Vascular smooth muscle cell effect on endothelial cell endothelin-1 production
Di Luozzo G, Bhargava J, Powell R. Vascular smooth muscle cell effect on endothelial cell endothelin-1 production. Journal Of Vascular Surgery 2000, 31: 781-789. PMID: 10753286, DOI: 10.1067/mva.2000.103788.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsET-1 productionEndothelin-1SMC proliferationEndothelial cellsNitro-L-arginine methyl esterNitric oxide synthase activityEC stimulationEndothelin-1 productionVascular lesion developmentNO synthase inhibitorOxide synthase activityEffects of SMCEts-1 proteinReceptor blockersCo-culture modelSMC inhibitionSynthase inhibitorLesion developmentB receptorMuscle cellsPotent mitogenRNA levelsProtein levelsPutative factors