2013
Hypothermia for aortic surgery
Griepp RB, Di Luozzo G. Hypothermia for aortic surgery. Journal Of Thoracic And Cardiovascular Surgery 2013, 145: s56-s58. PMID: 23410782, DOI: 10.1016/j.jtcvs.2012.11.072.Peer-Reviewed Original ResearchConceptsHypothermic circulatory arrestCirculatory arrestAcceptable neurologic outcomesAortic arch repairThoracoabdominal aortic aneurysmsAortic surgeryNeurologic outcomeArch repairSurgical patientsBrain metabolismOrgan protectionAortic aneurysmDeep hypothermiaClinical practicePig modelRoutine useHypothermiaArrestRepairPatientsSurgeryAneurysmsPerfusion
2012
Open Repair of Descending and Thoracoabdominal Aortic Aneurysms and Dissections in Patients Aged Younger Than 60 Years: Superior to Endovascular Repair?
Di Luozzo G, Geisbüsch S, Lin HM, Bischoff MS, Schray D, Pawale A, Griepp RB. Open Repair of Descending and Thoracoabdominal Aortic Aneurysms and Dissections in Patients Aged Younger Than 60 Years: Superior to Endovascular Repair? The Annals Of Thoracic Surgery 2012, 95: 12-19. PMID: 22785215, DOI: 10.1016/j.athoracsur.2012.05.071.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAortic Aneurysm, ThoracicAortic DissectionBlood Vessel Prosthesis ImplantationCirculatory Arrest, Deep Hypothermia InducedFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedNew YorkRetrospective StudiesStentsSurvival RateTime FactorsTreatment OutcomeYoung AdultConceptsThoracoabdominal aortic aneurysmsEndovascular repairOpen repairStent graftingAortic aneurysmDeep hypothermic circulatory arrestPrevious aortic operationHypothermic circulatory arrestOpen surgical repairNeurologic complication rateCerebrospinal fluid drainageModality of choiceChronic dissectionAcute dissectionAortic complicationsAortic operationsDiversity of patientsYounger patientsCirculatory arrestCommon indicationComplication rateNeurologic monitoringSurgical repairEarly mortalityLinearized rateCerebral Protection for Aortic Arch Surgery: Deep Hypothermia
Di Luozzo G, Griepp RB. Cerebral Protection for Aortic Arch Surgery: Deep Hypothermia. Seminars In Thoracic And Cardiovascular Surgery 2012, 24: 127-130. PMID: 22920529, DOI: 10.1053/j.semtcvs.2011.12.006.Peer-Reviewed Original ResearchConceptsAortic arch surgeryArch surgeryDeep hypothermiaDeep hypothermic circulatory arrestBranched graft techniqueSelective cerebral perfusionTotal arch replacementHypothermic circulatory arrestAortic arch aneurysmArch replacementCerebral protectionArch aneurysmCerebral perfusionCirculatory arrestSurgical outcomesCardiac surgeonsGraft techniqueSurgeryHypothermiaAneurysmsPerfusionSurgeonsTechnical aspectsSelective cerebral perfusion for thoracic aortic surgery: Association with neurocognitive outcome
Uysal S, Lin HM, Fischer GW, Di Luozzo G, Reich DL. Selective cerebral perfusion for thoracic aortic surgery: Association with neurocognitive outcome. Journal Of Thoracic And Cardiovascular Surgery 2012, 143: 1205-1212. PMID: 22306226, DOI: 10.1016/j.jtcvs.2012.01.012.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAorta, ThoracicCardiopulmonary BypassCerebrovascular CirculationChi-Square DistributionCirculatory Arrest, Deep Hypothermia InducedCognitionCognition DisordersFemaleHumansLinear ModelsLogistic ModelsMaleMiddle AgedNeuropsychological TestsNew York CityPerfusionProspective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeVascular Surgical ProceduresConceptsSelective cerebral perfusionHypothermic circulatory arrestSelective cerebral perfusion timeCerebral perfusion timeCardiopulmonary bypass timeThoracic aortic surgeryCerebral perfusionCardiopulmonary bypassCirculatory arrestAortic surgeryBypass timeSurgical patientsNeurocognitive outcomesPerfusion timeHypothermic circulatory arrest timeAortic arch surgeryBrain protection strategiesGroup 3 patientsOptimal brain protectionPostoperative neurocognitive testingGroup 1 patientsGroup 2 patientsThoracic aortic repairCirculatory arrest timeNeurocognitive test scores
2011
A propensity score–matched comparison of deep versus mild hypothermia during thoracoabdominal aortic surgery
Weiss AJ, Lin HM, Bischoff MS, Scheumann J, Lazala R, Griepp RB, Di Luozzo G. A propensity score–matched comparison of deep versus mild hypothermia during thoracoabdominal aortic surgery. Journal Of Thoracic And Cardiovascular Surgery 2011, 143: 186-193. PMID: 21885069, DOI: 10.1016/j.jtcvs.2011.07.020.Peer-Reviewed Original ResearchConceptsPermanent adverse outcomesThoracoabdominal aortic aneurysm repairDeep hypothermic circulatory arrestAortic aneurysm repairHypothermic circulatory arrestAdverse outcomesHypothermic circulatory arrest groupCirculatory arrest groupRenal failureLiver failureAneurysm repairCirculatory arrestArrest groupHypothermic circulatory arrest techniqueThoracoabdominal aortic aneurysm operationsPropensity score-matched analysisPropensity score-matched comparisonAortic aneurysm operationsPropensity-matched studySignificant decreased oddsThirty-day mortalityThoracoabdominal aortic surgeryAcute renal failureAdverse outcome ratesElephant trunk procedure
2010
Experimental Basis and Clinical Studies of Brain Protection in Aortic Arch Surgery
Di Luozzo G, Griepp R. Experimental Basis and Clinical Studies of Brain Protection in Aortic Arch Surgery. 2010, 219-228. DOI: 10.1007/978-1-84996-293-3_18.Peer-Reviewed Original ResearchBrain protection strategiesHypothermic circulatory arrestBrain protectionComplex aortic arch diseaseAntegrade brain perfusionAortic arch surgeryAortic arch diseasePediatric cardiac surgeonsArch diseaseArch surgeryCirculatory arrestBrain metabolismAortic aneurysmAortic archBrain perfusionSurgical techniqueClinical studiesCardiac surgeonsClinical practiceResectionSurgeryAneurysmsHypothermiaCommon denominatorPerfusionMathematical model for describing cerebral oxygen desaturation in patients undergoing deep hypothermic circulatory arrest
Fischer GW, Benni PB, Lin H, Satyapriya A, Afonso A, Di Luozzo G, Griepp RB, Reich DL. Mathematical model for describing cerebral oxygen desaturation in patients undergoing deep hypothermic circulatory arrest. British Journal Of Anaesthesia 2010, 104: 59-66. PMID: 19933513, PMCID: PMC2791548, DOI: 10.1093/bja/aep335.Peer-Reviewed Original ResearchConceptsDeep hypothermic circulatory arrestHypothermic circulatory arrestCirculatory arrestCerebral desaturationArrest timeMin of DHCACerebral oxygen desaturationAortic arch diseaseArch diseaseAortic surgeryIschemic thresholdNeurological sequelaeOxygen desaturationCerebral oximetryCerebral ischaemiaSurgical treatmentPatient heightPatientsDesaturationArrestMixed modelsX logIschaemiaSequelaeSurgery
2009
Redo Lateral Thoracotomy for Reoperative Descending and Thoracoabdominal Aortic Repair: A Consecutive Series of 60 Patients
Etz CD, Zoli S, Kari FA, Mueller CS, Bodian CA, Di Luozzo G, Plestis KA, Griepp RB. Redo Lateral Thoracotomy for Reoperative Descending and Thoracoabdominal Aortic Repair: A Consecutive Series of 60 Patients. The Annals Of Thoracic Surgery 2009, 88: 758-767. PMID: 19699894, DOI: 10.1016/j.athoracsur.2009.04.140.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAortic Aneurysm, ThoracicAortic CoarctationAortic DiseasesAortic DissectionAtherosclerosisCardiopulmonary BypassCirculatory Arrest, Deep Hypothermia InducedEvoked Potentials, MotorEvoked Potentials, SomatosensoryFemaleHeart Bypass, LeftHospital MortalityHumansKaplan-Meier EstimateMaleMarfan SyndromeMiddle AgedNeurologic ExaminationPostoperative ComplicationsReoperationSurvival RateThoracotomyYoung AdultConceptsPartial left heart bypassSegmental artery pairsHypothermic circulatory arrestLeft heart bypassPartial cardiopulmonary bypassPermanent dialysisAtherosclerotic aneurysmsCirculatory arrestCardiopulmonary bypassHeart bypassAdverse outcomesExtensive adhesionsThoracoabdominal aortic aneurysm surgeryArtery pairsChronic obstructive pulmonary diseaseAortic aneurysm surgeryIntensive care unit recoveryObstructive pulmonary diseaseThoracoabdominal aortic repairCoronary artery diseaseAneurysm extentHospital mortalityRedo thoracotomyTAAA repairRespiratory complicationsDirect Spinal Cord Perfusion Pressure Monitoring in Extensive Distal Aortic Aneurysm Repair
Etz CD, Di Luozzo G, Zoli S, Lazala R, Plestis KA, Bodian CA, Griepp RB. Direct Spinal Cord Perfusion Pressure Monitoring in Extensive Distal Aortic Aneurysm Repair. The Annals Of Thoracic Surgery 2009, 87: 1764-1774. PMID: 19463592, DOI: 10.1016/j.athoracsur.2009.02.101.Peer-Reviewed Original ResearchConceptsSpinal cord perfusion pressureDeep hypothermic circulatory arrestThoracoabdominal aortic aneurysmsAortic aneurysm repairHypothermic circulatory arrestNonpulsatile cardiopulmonary bypassCardiopulmonary bypassPerfusion pressureSegmental arteriesEndovascular repairAneurysm repairCirculatory arrestAortic aneurysmThoracoabdominal aortic aneurysm repairNormal spinal cord functionPerfusion pressure monitoringThoracic segmental arteriesMean arterial pressureSpinal cord functionSpinal cord recoveryParaspinal collateral networkArterial pressureCord functionCollateral networkPressure monitoringSupradiaphragmatic Inferior Vena Cava Cannulation for Thoracoabdominal Aortic Aneurysm Repair
Di Luozzo G, Etz CD, Griepp RB. Supradiaphragmatic Inferior Vena Cava Cannulation for Thoracoabdominal Aortic Aneurysm Repair. The Annals Of Thoracic Surgery 2009, 87: 1286-1288. PMID: 19324177, DOI: 10.1016/j.athoracsur.2008.07.025.Peer-Reviewed Original ResearchConceptsSupradiaphragmatic inferior vena cavaThoracoabdominal aortic aneurysm repairDeep hypothermic circulatory arrestFemoral venous accessAortic aneurysm repairHypothermic circulatory arrestInferior vena cavaSite of cannulationThoracoabdominal aneurysmsCirculatory arrestAneurysm repairCardiopulmonary bypassCardiopulmonary supportVenous accessCannulation siteVena cavaPreoperative preparationCannulationRare occasions
2007
Aortic root reconstruction with a bioprosthetic valved conduit: A consecutive series of 275 procedures
Etz CD, Homann TM, Rane N, Bodian CA, Di Luozzo G, Plestis KA, Spielvogel D, Griepp RB. Aortic root reconstruction with a bioprosthetic valved conduit: A consecutive series of 275 procedures. Journal Of Thoracic And Cardiovascular Surgery 2007, 133: 1455-1463. PMID: 17532939, DOI: 10.1016/j.jtcvs.2007.01.058.Peer-Reviewed Original ResearchConceptsBioprosthetic valved conduitAortic root reconstructionValved conduitRoot reconstructionExtensive arch reconstructionOpen distal anastomosisPostoperative mortality rateAortic root replacementPatients 12 yearsRate of strokeHypothermic circulatory arrestLong-term outcomesLong-term survivalDegenerative aneurysmsHemiarch reconstructionHospital mortalityPermanent strokeAtherosclerotic aneurysmsRoot replacementArch reconstructionCirculatory arrestDistal anastomosisAdditional patientsDacron graftSignificant hemorrhage