2012
Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: Results from the DIAD study
Tandon S, Wackers F, Inzucchi SE, Bansal S, Staib LH, Chyun DA, Davey JA, Young LH. Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: Results from the DIAD study. Diabetes And Vascular Disease Research 2012, 9: 124-130. PMID: 22228772, DOI: 10.1177/1479164111431470.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsymptomatic DiseasesCanadaCardiovascular DiseasesDiabetes ComplicationsDiabetes Mellitus, Type 2FemaleHumansIncidenceKaplan-Meier EstimateMaleMass ScreeningMiddle AgedMyocardial Perfusion ImagingPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsSex FactorsTime FactorsUnited StatesConceptsType 2 diabetesMyocardial perfusion imagingCardiovascular outcomesStress myocardial perfusion imagingAsymptomatic Diabetics (DIAD) studyBetter cardiac outcomesHigh-risk womenCoronary artery diseaseHigh-risk menDetection of ischemiaMPI abnormalitiesAsymptomatic patientsAsymptomatic menCardiac eventsCardiac outcomesArtery diseaseAsymptomatic womenAbnormal screeningDiabetic studyPerfusion imagingDIAD studyWomenMenDiabetesOutcomes
2010
Hyperglycemia on admission predicts larger infarct size in patients undergoing percutaneous coronary intervention for acute ST-segment elevation myocardial infarction
Cruz-Gonzalez I, Chia S, Raffel O, Sanchez-Ledesma M, Senatore F, Wackers F, Nathan D, Jang I. Hyperglycemia on admission predicts larger infarct size in patients undergoing percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Diabetes Research And Clinical Practice 2010, 88: 97-102. PMID: 20083319, DOI: 10.1016/j.diabres.2010.01.001.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionAcute ST-segment elevation myocardial infarctionPrimary PCILarger infarct sizeElevation myocardial infarctionPercutaneous coronary interventionInfarct sizeCoronary interventionMyocardial infarctionDay 5Final TIMI 3 flowTIMI 3 flowMultivariate linear regression analysisSingle photon emissionAdmission correlateSTEMI patientsBaseline characteristicsDiabetic statusHyperglycemia groupIndependent predictorsHyperglycemiaPatientsLinear regression analysisAdmission
2009
How to Identify the Asymptomatic High-Risk Patient?
Schuijf J, Achenbach S, Zoghbi W, Boersma E, Raggi P, Weber M, Nagel E, Narula J, Wackers F, Poldermans D, Bax J. How to Identify the Asymptomatic High-Risk Patient? Current Problems In Cardiology 2009, 34: 539-577. PMID: 19804855, DOI: 10.1016/j.cpcardiol.2009.07.001.Peer-Reviewed Original ResearchConceptsElevated riskAsymptomatic high-risk patientsCardiovascular disease eventsHigh-risk patientsCause of mortalityUse of biomarkersNoninvasive imaging modalityIntermediate riskAsymptomatic individualsCardiovascular diseaseHigh riskDisease eventsPreventive measuresImaging modalitiesSubstantial proportionMorbidityPatientsRisk assessmentAdditional strategiesRiskMortalityTraditional risk assessmentLarge proportionGreat benefitIndividualsLessons learned from the detection of ischemia in asymptomatic diabetics (DIAD) study
Wackers FJ, Young LH. Lessons learned from the detection of ischemia in asymptomatic diabetics (DIAD) study. Journal Of Nuclear Cardiology 2009, 16: 855-859. PMID: 19685266, DOI: 10.1007/s12350-009-9138-1.Commentaries, Editorials and Letters
2008
Utility of Cardiac Biomarkers in Predicting Infarct Size, Left Ventricular Function, and Clinical Outcome After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction
Chia S, Senatore F, Raffel O, Lee H, Wackers F, Jang I. Utility of Cardiac Biomarkers in Predicting Infarct Size, Left Ventricular Function, and Clinical Outcome After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction. JACC Cardiovascular Interventions 2008, 1: 415-423. PMID: 19463339, DOI: 10.1016/j.jcin.2008.04.010.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryBenzenesulfonatesBiomarkersCardiovascular AgentsCoronary AngiographyCreatine Kinase, MB FormDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionMyocardiumPiperazinesPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentStroke VolumeTime FactorsTomography, Emission-Computed, Single-PhotonTreatment OutcomeTroponin ITroponin TUnited StatesVentricular Function, LeftConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionPrimary PCIElevation myocardial infarctionPercutaneous coronary interventionInfarct sizeClinical outcomesMyocardial infarctionCardiac biomarkersCoronary interventionCreatine kinaseCK-MBLarge ST-segment elevation myocardial infarctionTroponin TIntracellular calcium modulatorsLarger infarct sizeVentricular ejection fractionCardiac biomarker levelsLeft ventricular functionComposite clinical eventsTime-concentration curveEVOLVE trialLower LVEFAdverse eventsEjection fractionDifferent manifestations of coronary artery disease by stress SPECT myocardial perfusion imaging, coronary calcium scoring, and multislice CT coronary angiography in asymptomatic patients with type 2 diabetes mellitus
Scholte A, Schuijf J, Kharagjitsingh A, Dibbets-Schneider P, Stokkel M, Jukema J, van der Wall E, Bax J, Wackers F. Different manifestations of coronary artery disease by stress SPECT myocardial perfusion imaging, coronary calcium scoring, and multislice CT coronary angiography in asymptomatic patients with type 2 diabetes mellitus. Journal Of Nuclear Cardiology 2008, 15: 503-509. PMID: 18674717, DOI: 10.1016/j.nuclcard.2008.02.015.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCalcinosisComorbidityCoronary Artery DiseaseDiabetes Mellitus, Type 2FemaleHumansIncidenceMaleMiddle AgedNetherlandsReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedVentricular Dysfunction, LeftConceptsType 2 diabetes mellitusCoronary artery diseaseMSCT coronary angiographyAsymptomatic patientsCoronary angiographyDiabetes mellitusPositive CAC scoreMyocardial perfusion imagingCAC scoreCoronary atherosclerosisArtery diseaseCAC scoringCalcium scoringPerfusion imagingAbnormal diagnostic test resultsSilent coronary artery diseaseStress single-photon emissionCoronary artery calcium scoringMultislice CT coronary angiographyTomography myocardial perfusion imagingStress SPECT myocardial perfusion imagingSilent coronary atherosclerosisSPECT myocardial perfusion imagingRelative prognostic valueTomographic coronary angiography
2007
A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: Evaluation of MCC-135 for left ventricular salvage in acute myocardial infarction (EVOLVE)
Jang I, Weissman N, Picard M, Zile M, Pettigrew V, Shen S, Tatsuno J, Hibberd M, Tzivoni D, Wackers F, Investigators T. A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: Evaluation of MCC-135 for left ventricular salvage in acute myocardial infarction (EVOLVE). American Heart Journal 2007, 155: 113.e1-113.e8. PMID: 18082500, DOI: 10.1016/j.ahj.2007.08.020.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryBenzenesulfonatesCardiac CatheterizationCombined Modality TherapyCoronary AngiographyDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleElectrocardiographyFemaleFollow-Up StudiesHumansInfusions, IntravenousMaleMiddle AgedMyocardial InfarctionPiperazinesProbabilityReference ValuesRisk AssessmentSalvage TherapyStroke VolumeSurvival RateTreatment OutcomeVentricular Function, LeftConceptsPrimary percutaneous coronary interventionLeft ventricular ejection fractionST-elevation myocardial infarctionPrimary PCIMCC-135Percutaneous coronary interventionAcute myocardial infarctionInfarct sizeMyocardial infarctionDay 5Coronary interventionClinical outcomesCalcium overloadPreservation of LVEFAcute ST-elevation myocardial infarctionEnd pointTarget populationComposite clinical outcomeLeft Ventricular SalvagePlacebo-controlled studyPrimary end pointSecondary end pointsLow-dose groupVentricular ejection fractionHigh-dose group
2006
Screening Asymptomatic Diabetic Patients for Coronary Artery Disease Why Not?
Miller T, Redberg R, Wackers F. Screening Asymptomatic Diabetic Patients for Coronary Artery Disease Why Not? Journal Of The American College Of Cardiology 2006, 48: 761-764. PMID: 16904546, DOI: 10.1016/j.jacc.2006.04.076.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseAsymptomatic diabetic patientsDiabetic patientsArtery diseaseSilent coronary artery diseaseStress single-photon emissionImportant coronary artery diseaseAnti-ischemic medicationNon-diabetic patientsClinical scoring systemAbnormal SPECT imagesSingle photon emissionCardiovascular eventsAggressive treatmentDiabetes statusPatient subsetsHigh prevalenceScreening programElevated riskHigh riskPatientsConsensus documentTrue prevalenceScoring systemDIAD studyThe Impact of Screening for Asymptomatic Myocardial Ischemia in Individuals With Type 2 Diabetes
Chyun DA, Katten DM, Melkus GD, Talley S, Davey JA, Wackers FJ. The Impact of Screening for Asymptomatic Myocardial Ischemia in Individuals With Type 2 Diabetes. The Journal Of Cardiovascular Nursing 2006, 21: e1-e7. PMID: 16601520, DOI: 10.1097/00005082-200603000-00015.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAntihypertensive AgentsAnxietyAspirinDepressionDiabetes Mellitus, Type 2EmotionsFemaleFibrinolytic AgentsFollow-Up StudiesHealth BehaviorHumansHypolipidemic AgentsMaleMass ScreeningMiddle AgedMotor ActivityMultivariate AnalysisMyocardial IschemiaPersonal AutonomyProspective StudiesQuality of LifeRisk AssessmentSocioeconomic FactorsConceptsCoronary artery diseaseType 2 diabetesAsymptomatic coronary artery diseasePoor emotional outcomesAsymptomatic myocardial ischemiaRisk factor behaviorsImpact of screeningSelf-administered questionnaireAggressive screeningArtery diseaseProspective studyStudy baselineMyocardial ischemiaScreening TrialMyocardial perfusionEmotional outcomesOutcomesDiabetesBehavior outcomesLaboratory testsLow levelsScreeningHigh levelsIschemiaPerfusionTo the editor
Venkataraman R, Al-Shaer M, Wackers F. To the editor. Journal Of Nuclear Cardiology 2006, 13: 300-300. DOI: 10.1007/bf02971255.Peer-Reviewed Original ResearchAdultAgedBlood Flow VelocityBrachial ArteryCoronary Artery DiseaseData Interpretation, StatisticalEndothelium, VascularExercise TestFemaleHumansIncidenceMaleRadionuclide ImagingRadiopharmaceuticalsReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificitySeverity of Illness IndexThalliumUltrasonographyLetter to the Editor
Venkataraman R, Al-Shaer M, Wackers F. Letter to the Editor. Journal Of Nuclear Cardiology 2006, 13: 300. PMID: 16580967, DOI: 10.1016/j.nuclcard.2006.01.009.Peer-Reviewed Original ResearchAdultAgedBlood Flow VelocityBrachial ArteryCoronary Artery DiseaseData Interpretation, StatisticalEndothelium, VascularExercise TestFemaleHumansIncidenceMaleRadionuclide ImagingRadiopharmaceuticalsReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificitySeverity of Illness IndexThalliumUltrasonographyScreening of asymptomatic patients with type 2 diabetes mellitus for silent coronary artery disease: Combined use of stress myocardial perfusion imaging and coronary calcium scoring
Scholte A, Bax J, Wackers F. Screening of asymptomatic patients with type 2 diabetes mellitus for silent coronary artery disease: Combined use of stress myocardial perfusion imaging and coronary calcium scoring. Journal Of Nuclear Cardiology 2006, 13: 11-18. PMID: 16464712, DOI: 10.1016/j.nuclcard.2005.11.002.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsCalcinosisComorbidityCoronary Artery DiseaseDiabetes Mellitus, Type 2Diagnosis, Computer-AssistedExercise TestHumansIncidenceMass ScreeningPrognosisRadionuclide ImagingReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificitySurvival RateVentricular Dysfunction, LeftConceptsSilent coronary artery diseaseCoronary artery diseaseCoronary calcium scoringType 2 diabetes mellitusMyocardial perfusion imagingArtery diseaseDiabetes mellitusCalcium scoringPerfusion imagingAsymptomatic individualsStress myocardial perfusion imagingRadionuclide myocardial perfusion imagingEarly appropriate treatmentRecent prospective studiesRates of morbidityAsymptomatic patientsCardiovascular complicationsProspective studyOverall prevalenceClinical combinationAppropriate treatmentClinical investigationMellitusClinical importanceDisease
2004
Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics–Brachial Artery Reactivity study)
Papaioannou GI, Seip RL, Grey NJ, Katten D, Taylor A, Inzucchi SE, Young LH, Chyun DA, Davey JA, Wackers FJ, Iskandrian AE, Ratner RE, Robinson EC, Carolan S, Engel S, Heller GV. Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics–Brachial Artery Reactivity study). The American Journal Of Cardiology 2004, 94: 294-299. PMID: 15276091, DOI: 10.1016/j.amjcard.2004.04.022.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAlbuminuriaBrachial ArteryCoronary Artery DiseaseC-Reactive ProteinDiabetes Mellitus, Type 2Diabetic AngiopathiesEndothelium, VascularFemaleHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisProspective StudiesReference ValuesRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexSex FactorsUltrasonography, DopplerVasoconstrictionVasodilationConceptsEndothelium-independent vasodilationEndothelium-dependent vasodilationBrachial artery reactivityType 2 diabetes mellitusHormone replacement therapyDiabetes mellitusC-reactive proteinSystemic inflammationAsymptomatic patientsEndothelial dysfunctionIndependent predictorsReplacement therapyNovel atherosclerotic risk factorAsymptomatic Diabetics (DIAD) studyAtherosclerotic risk factorsPresence of microalbuminuriaFuture cardiovascular eventsSimilar baseline characteristicsDetection of ischemiaCardiovascular eventsBaseline characteristicsBrachial arteryVascular dysfunctionEntire cohortRisk factorsAcute rest myocardial perfusion imaging for chest pain
Kontos M, Wackers F. Acute rest myocardial perfusion imaging for chest pain. Journal Of Nuclear Cardiology 2004, 11: 470-481. PMID: 15295416, DOI: 10.1016/j.nuclcard.2004.05.004.Peer-Reviewed Original Research
1996
Detection and significance of myocardial ischemia in women versus men within six months of acute myocardial infarction or unstable angina
Moriel M, Benhorin J, Brown M, Raubertas R, Severski P, Van Voorhees L, Bodenheimer M, Tzivoni D, Wackers F, Moss A, Group T. Detection and significance of myocardial ischemia in women versus men within six months of acute myocardial infarction or unstable angina. The American Journal Of Cardiology 1996, 77: 798-804. PMID: 8623730, DOI: 10.1016/s0002-9149(97)89172-2.Peer-Reviewed Original ResearchConceptsAcute coronary eventsThallium-201 stress scintigraphyPrimary end pointCoronary eventsEnd pointUnstable anginaStress scintigraphyPatient 1Myocardial infarctionNoninvasive testsExercise electrocardiogramAmbulatory electrocardiogramIschemia detectionCardiac event rateNonfatal myocardial infarctionSubsequent cardiac eventsAcute myocardial infarctionCardiac eventsIschemia testCardiac deathCox analysisPrognostic significanceMyocardial ischemiaEvent ratesWomen
1994
Limited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulator patients several months after recovery from an acute coronary event: Implications for management of stable coronary heart disease
Krone R, Gregory J, Freedland K, Kleiger R, Wackers F, Bodenheimer M, Benhorin J, Schwartz R, Parker J, van Voorhees L, Moss A, Group F. Limited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulator patients several months after recovery from an acute coronary event: Implications for management of stable coronary heart disease. Journal Of The American College Of Cardiology 1994, 24: 1274-1281. PMID: 7930250, DOI: 10.1016/0735-1097(94)90109-0.Peer-Reviewed Original ResearchConceptsStable coronary diseaseAcute coronary eventsNonfatal myocardial infarctionThallium-201 scintigraphyCardiac eventsCoronary eventsCoronary diseaseCardiac deathHospital admissionMyocardial infarctionNonfatal infarctionEnd pointUnstable anginaExercise testingObstructive coronary artery diseaseStable coronary heart diseaseExercise testing variablesSubsequent cardiac eventsCoronary artery diseaseGroup of patientsCoronary heart diseaseProportional hazards modelThallium perfusionCardiac causesIdentifies patients