2014
Predictors of Physical Inactivity in Men and Women With Type 2 Diabetes From the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study
McCarthy M, Davey J, Wackers F, Chyun D. Predictors of Physical Inactivity in Men and Women With Type 2 Diabetes From the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study. The Science Of Diabetes Self-Management And Care 2014, 40: 678-687. PMID: 24942531, PMCID: PMC4169341, DOI: 10.1177/0145721714540055.Peer-Reviewed Original ResearchMeSH KeywordsCanadaDiabetes Mellitus, Type 2Diabetic AngiopathiesExerciseFemaleFollow-Up StudiesHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedMotor ActivityMyocardial IschemiaPeripheral Nervous System DiseasesPredictive Value of TestsPrevalenceProspective StudiesRisk FactorsSedentary BehaviorTime FactorsUnited StatesConceptsAsymptomatic Diabetics (DIAD) studyPhysical inactivityType 2 diabetesDetection of ischemiaDiabetic studyOverweight/obesityPrimary care practicesPhysical activity dataGender-related differencesAsymptomatic patientsAutonomic neuropathySilent ischemiaSecondary data analysisCare practicesType 2Secondary analysisIschemiaDiabetesTime pointsInactivityBaselineWomenMenGender differencesYears
2012
Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: Results from the DIAD study
Tandon S, Wackers F, Inzucchi SE, Bansal S, Staib LH, Chyun DA, Davey JA, Young LH. Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: Results from the DIAD study. Diabetes And Vascular Disease Research 2012, 9: 124-130. PMID: 22228772, DOI: 10.1177/1479164111431470.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsymptomatic DiseasesCanadaCardiovascular DiseasesDiabetes ComplicationsDiabetes Mellitus, Type 2FemaleHumansIncidenceKaplan-Meier EstimateMaleMass ScreeningMiddle AgedMyocardial Perfusion ImagingPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsSex FactorsTime FactorsUnited StatesConceptsType 2 diabetesMyocardial perfusion imagingCardiovascular outcomesStress myocardial perfusion imagingAsymptomatic Diabetics (DIAD) studyBetter cardiac outcomesHigh-risk womenCoronary artery diseaseHigh-risk menDetection of ischemiaMPI abnormalitiesAsymptomatic patientsAsymptomatic menCardiac eventsCardiac outcomesArtery diseaseAsymptomatic womenAbnormal screeningDiabetic studyPerfusion imagingDIAD studyWomenMenDiabetesOutcomes
2008
Utility of Cardiac Biomarkers in Predicting Infarct Size, Left Ventricular Function, and Clinical Outcome After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction
Chia S, Senatore F, Raffel O, Lee H, Wackers F, Jang I. Utility of Cardiac Biomarkers in Predicting Infarct Size, Left Ventricular Function, and Clinical Outcome After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction. JACC Cardiovascular Interventions 2008, 1: 415-423. PMID: 19463339, DOI: 10.1016/j.jcin.2008.04.010.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryBenzenesulfonatesBiomarkersCardiovascular AgentsCoronary AngiographyCreatine Kinase, MB FormDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionMyocardiumPiperazinesPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentStroke VolumeTime FactorsTomography, Emission-Computed, Single-PhotonTreatment OutcomeTroponin ITroponin TUnited StatesVentricular Function, LeftConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionPrimary PCIElevation myocardial infarctionPercutaneous coronary interventionInfarct sizeClinical outcomesMyocardial infarctionCardiac biomarkersCoronary interventionCreatine kinaseCK-MBLarge ST-segment elevation myocardial infarctionTroponin TIntracellular calcium modulatorsLarger infarct sizeVentricular ejection fractionCardiac biomarker levelsLeft ventricular functionComposite clinical eventsTime-concentration curveEVOLVE trialLower LVEFAdverse eventsEjection fraction
2006
The Impact of Screening for Asymptomatic Myocardial Ischemia in Individuals With Type 2 Diabetes
Chyun DA, Katten DM, Melkus GD, Talley S, Davey JA, Wackers FJ. The Impact of Screening for Asymptomatic Myocardial Ischemia in Individuals With Type 2 Diabetes. The Journal Of Cardiovascular Nursing 2006, 21: e1-e7. PMID: 16601520, DOI: 10.1097/00005082-200603000-00015.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAntihypertensive AgentsAnxietyAspirinDepressionDiabetes Mellitus, Type 2EmotionsFemaleFibrinolytic AgentsFollow-Up StudiesHealth BehaviorHumansHypolipidemic AgentsMaleMass ScreeningMiddle AgedMotor ActivityMultivariate AnalysisMyocardial IschemiaPersonal AutonomyProspective StudiesQuality of LifeRisk AssessmentSocioeconomic FactorsConceptsCoronary artery diseaseType 2 diabetesAsymptomatic coronary artery diseasePoor emotional outcomesAsymptomatic myocardial ischemiaRisk factor behaviorsImpact of screeningSelf-administered questionnaireAggressive screeningArtery diseaseProspective studyStudy baselineMyocardial ischemiaScreening TrialMyocardial perfusionEmotional outcomesOutcomesDiabetesBehavior outcomesLaboratory testsLow levelsScreeningHigh levelsIschemiaPerfusion
2004
Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics–Brachial Artery Reactivity study)
Papaioannou GI, Seip RL, Grey NJ, Katten D, Taylor A, Inzucchi SE, Young LH, Chyun DA, Davey JA, Wackers FJ, Iskandrian AE, Ratner RE, Robinson EC, Carolan S, Engel S, Heller GV. Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics–Brachial Artery Reactivity study). The American Journal Of Cardiology 2004, 94: 294-299. PMID: 15276091, DOI: 10.1016/j.amjcard.2004.04.022.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAlbuminuriaBrachial ArteryCoronary Artery DiseaseC-Reactive ProteinDiabetes Mellitus, Type 2Diabetic AngiopathiesEndothelium, VascularFemaleHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisProspective StudiesReference ValuesRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexSex FactorsUltrasonography, DopplerVasoconstrictionVasodilationConceptsEndothelium-independent vasodilationEndothelium-dependent vasodilationBrachial artery reactivityType 2 diabetes mellitusHormone replacement therapyDiabetes mellitusC-reactive proteinSystemic inflammationAsymptomatic patientsEndothelial dysfunctionIndependent predictorsReplacement therapyNovel atherosclerotic risk factorAsymptomatic Diabetics (DIAD) studyAtherosclerotic risk factorsPresence of microalbuminuriaFuture cardiovascular eventsSimilar baseline characteristicsDetection of ischemiaCardiovascular eventsBaseline characteristicsBrachial arteryVascular dysfunctionEntire cohortRisk factors
1996
Comparison of Nifedipine GITS and Hydrochlorothiazide in the Management of Elderly Patients with Stage I–III Diastolic Hypertension*
Dey H, Soufer R, Hoffer P, Wackers F, Black H. Comparison of Nifedipine GITS and Hydrochlorothiazide in the Management of Elderly Patients with Stage I–III Diastolic Hypertension*. American Journal Of Hypertension 1996, 9: 598-606. PMID: 8783785, DOI: 10.1016/0895-7061(96)00168-9.Peer-Reviewed Original ResearchConceptsNifedipine gastrointestinal therapeutic systemGastrointestinal therapeutic systemDiastolic blood pressureBlood pressureDiastolic hypertensionStage IVentricular massCardiovascular functionTreatment differencesGoal diastolic blood pressureSignificant blood pressure reductionWeek placebo washout phasePlacebo washout phaseWeek maintenance phaseBlood pressure reductionGoal blood pressureDiastolic filling rateRenal blood flowGlomerular filtration rateLeft ventricular massBlood urea nitrogenShort-term therapyAdverse side effectsSignificant adverse effectsDiuretic therapy
1995
Preoperative Dipyridamole Thallium Imaging and Ambulatory Electrocardiographic Monitoring as a Predictor of Perioperative Cardiac Events and Long-term Outcome
Fleisher L, Rosenbaum S, Nelson A, Jain D, Wackers F, Zaret B. Preoperative Dipyridamole Thallium Imaging and Ambulatory Electrocardiographic Monitoring as a Predictor of Perioperative Cardiac Events and Long-term Outcome. Anesthesiology 1995, 83: 906-917.. PMID: 7486176, DOI: 10.1097/00000542-199511000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overDipyridamoleElectrocardiography, AmbulatoryFemaleHeart DiseasesHumansIntraoperative ComplicationsMaleMiddle AgedPostoperative ComplicationsPredictive Value of TestsPreoperative CarePrognosisProspective StudiesRadionuclide AngiographySensitivity and SpecificitySurvival AnalysisThallium RadioisotopesVasodilator AgentsConceptsPerioperative cardiac eventsPredictive valueDipyridamole thalliumCardiac eventsPreoperative dipyridamole thallium imagingLong-term cardiac survivalGreatest likelihood ratioNoncardiac surgery patientsPerioperative cardiac morbidityDipyridamole-thallium imagingLong-term mortalityLong-term prognosisAmbulatory electrocardiographic monitoringShort-term outcomesLong-term outcomesLikelihood ratioPositive predictive valueLog-rank statisticsNuclear cardiology laboratoryCardiac morbidityNoncardiac surgerySurgery patientsThallium imagingCardiac survivalElectrocardiographic monitoring
1993
Detection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group.
Moss A, Goldstein R, Hall W, Bigger J, Fleiss J, Greenberg H, Bodenheimer M, Krone R, Marcus F, Wackers F. Detection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group. JAMA 1993, 269: 2379-85. PMID: 8479063, DOI: 10.1001/jama.269.18.2379.Peer-Reviewed Original ResearchConceptsAcute coronary eventsSymptomatic myocardial ischemiaCoronary eventsST depressionMyocardial ischemiaExercise-induced ST depressionReversible thallium-201 defectsSubsequent coronary eventsHigh-risk subsetST-segment depressionThallium-201 scintigraphyThallium-201 defectsAcute myocardial infarctionNoninvasive test resultsPrimary eventFirst primary eventsNon-invasive testingPostcoronary patientsRecent hospitalizationSegment depressionUnstable anginaAmbulatory outpatientsStable patientsExercise durationLung uptake
1991
Thallium-201 for assessment of myocardial viability: Quantitative comparison of 24-hour redistribution imaging with imaging after reinjection at rest
Kayden D, Sigal S, Soufer R, Mattera J, Zaret B, Wackers F. Thallium-201 for assessment of myocardial viability: Quantitative comparison of 24-hour redistribution imaging with imaging after reinjection at rest. Journal Of The American College Of Cardiology 1991, 18: 1480-1486. PMID: 1939949, DOI: 10.1016/0735-1097(91)90678-3.Peer-Reviewed Original ResearchConceptsInjection of thalliumRedistribution imagesDefect reversibilityThallium-201 reinjectionThallium-201 defectsLate redistribution imagingPoor quality studiesDiagnostic informationClinical variablesRedistribution imagingThallium defectsThallium imagesMyocardial viabilityReversible defectsStress imagingThallium-201PatientsBetter diagnostic informationStress testingExercisePresent studyQuality studiesInjectionLate redistributionReinjection
1990
Silent left ventricular dysfunction during routine activity after thrombolytic Therapy for acute myocardial infarction
Kayden D, Wackers F, Zaret B. Silent left ventricular dysfunction during routine activity after thrombolytic Therapy for acute myocardial infarction. Journal Of The American College Of Cardiology 1990, 15: 1500-1507. PMID: 2345230, DOI: 10.1016/0735-1097(90)92817-l.Peer-Reviewed Original ResearchConceptsTransient left ventricular dysfunctionLeft ventricular dysfunctionSilent left ventricular dysfunctionVentricular dysfunctionMyocardial infarctionCardiac eventsHospital dischargeEjection fractionThrombolytic therapySubmaximal supine bicycle exerciseNormal activityBaseline ejection fractionExercise test resultsSubsequent cardiac eventsSupine bicycle exerciseVentricular function monitoringAcute myocardial infarctionChest painPeak exerciseBicycle exerciseAmbulatory patientsElectrocardiographic changesPoor outcomePrognostic informationFunction monitoring
1989
Early image acquisition after administration of indium-111 platelets in clinically suspected deep venous thrombosis
Farlow D, Ezekowitz M, Rao S, Martinez C, Denny D, Morse S, Decho J, Wackers F, Strauss E. Early image acquisition after administration of indium-111 platelets in clinically suspected deep venous thrombosis. The American Journal Of Cardiology 1989, 64: 363-368. PMID: 2502903, DOI: 10.1016/0002-9149(89)90536-5.Peer-Reviewed Original ResearchConceptsDeep venous thrombosisVenous thrombosisPlatelet scintigraphyEarly imagingAsymptomatic high-risk patientsSymptomatic deep venous thrombosisAcute deep venous thrombosisIndium-111 platelet scintigraphyHigh-risk patientsIndium-111 plateletsEarly image acquisitionIndium-111 oxinePlatelet injectionPlatelet scanAnticoagulated patientsSymptomatic patientsContrast venographyRecent onsetTimely institutionIntravenous administrationScintigraphyBlinded observersPatientsThrombosisLow sensitivity
1988
Electrophysiologic effects of thrombolytic therapy in patients with a transmural anterior myocardial infarction complicated by left ventricular aneurysm formation
Sager P, Perlmutter R, Rosenfeld L, McPherson C, Wackers F, Batsford W. Electrophysiologic effects of thrombolytic therapy in patients with a transmural anterior myocardial infarction complicated by left ventricular aneurysm formation. Journal Of The American College Of Cardiology 1988, 12: 19-24. PMID: 3379204, DOI: 10.1016/0735-1097(88)90350-6.Peer-Reviewed Original ResearchConceptsGroup B patientsLeft ventricular aneurysm formationTransmural anterior myocardial infarctionGroup A patientsVentricular aneurysm formationAnterior myocardial infarctionThrombolytic therapyB patientsVentricular tachycardiaA patientsVentricular arrhythmiasMyocardial infarctionAneurysm formationNew bundle branch blockPeak creatine kinase-MB levelsLeft ventricular ejection fractionCreatine kinase-MB levelsClinical arrhythmic eventsEarly thrombolytic therapyCongestive heart failureVentricular ejection fractionSustained ventricular tachycardiaInduced ventricular arrhythmiasBundle branch blockPostmyocardial infarction patients