1996
Diagnostic utility of tomographic myocardial perfusion imaging with technetium 99m furifosmin (Q12) compared with thallium 201: Results of a phase III multicenter trial
Hendel R, Verani M, Miller D, Wackers F, McMahon M, Cerqueira M, Botvinick E, Kvols L, Gerson M. Diagnostic utility of tomographic myocardial perfusion imaging with technetium 99m furifosmin (Q12) compared with thallium 201: Results of a phase III multicenter trial. Journal Of Nuclear Cardiology 1996, 3: 291-300. PMID: 8799247, DOI: 10.1016/s1071-3581(96)90088-4.Peer-Reviewed Original ResearchConceptsMyocardial perfusion agentPerfusion agentMulticenter trialNormalcy ratePhase III multicenter trialCoronary artery diseaseTomographic myocardial perfusionMyocardial perfusion imagingPanel of readersNew myocardial perfusion agentNew perfusion tracerPeak exerciseArtery diseaseThallium scintigraphyPerfusion scintigraphyMyocardial scintigraphyExercise workloadStudy groupLaboratory alterationsMyocardial perfusionThallium-201Perfusion imagingDiagnostic utilityScintigraphyPerfusion studies
1995
Myocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group.
Zaret B, Rigo P, Wackers F, Hendel R, Braat S, Iskandrian A, Sridhara B, Jain D, Itti R, Serafini A, Goris M, Lahiri A. Myocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group. Circulation 1995, 91: 313-9. PMID: 7805233, DOI: 10.1161/01.cir.91.2.313.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseaseTetrofosmin imagingCoronary angiographyMyocardial perfusionTetrofosmin imagesHealthy subjectsPhase III multicenter trialConventional myocardial perfusionLower likelihoodCentral core laboratoryMyocardial perfusion abnormalitiesNew 99mTcPeak heart rateNegative predictive accuracyMyocardial perfusion imagingNew myocardial imaging agentPlanar 201TlMulticenter trialNormalcy rateCoronary angiogramDouble productPerfusion abnormalitiesMyocardial imaging agentRadiotracer injection
1993
Factors affecting uniformity in interpretation of planar thallium-201 imaging in a Multicenter trial
Wackers F, Bodenheimer M, Fleiss J, Brown M, Investigators T. Factors affecting uniformity in interpretation of planar thallium-201 imaging in a Multicenter trial. Journal Of The American College Of Cardiology 1993, 21: 1064-1074. PMID: 8459059, DOI: 10.1016/0735-1097(93)90226-q.Peer-Reviewed Original ResearchConceptsClinical centersThallium-201 imagesCore laboratoryClinical investigatorsSilent myocardial ischemiaPlanar thallium-201 imagesThallium-201 imagingLack of standardizationCircumferential profile analysisPlanar thallium-201 imagingReproducibility of interpretationMulticenter trialMulticenter studyMyocardial ischemiaMyocardial perfusion imagesSuboptimal reproducibilityInterobserver agreementKappa statisticsPerfusion imagesPoor interlaboratory agreementComputer quantificationObjective criteriaInterlaboratory agreementPoor agreementEffects of standardization