1995
Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia.
Shi CQ, Sinusas AJ, Dione DP, Singer MJ, Young LH, Heller EN, Rinker BD, Wackers FJ, Zaret BL. Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia. Journal Of Nuclear Medicine 1995, 36: 1078-86. PMID: 7769431.Peer-Reviewed Original ResearchConceptsIschemic regionMyocardial ischemiaBlood flowEx vivo SPECTRegional myocardial blood flowPartial coronary occlusionMicrosphere blood flowMyocardial blood flowOpen-chest canine modelVivo SPECT imagesSPECT imagesVivo planarCentral ischemic regionCoronary occlusionDemand ischemiaBMS181321Technetium-99mIntravenous injectionLiver ratioMyocardial imagingCanine modelPositive imagingHepatic clearanceLiver activityArterial sampling
1992
Tc-99m SestaMIBI: Will it replace Tl-201 in clinical cardiology?
Wackers F. Tc-99m SestaMIBI: Will it replace Tl-201 in clinical cardiology? Developments In Cardiovascular Medicine 1992, 128: 239-248. DOI: 10.1007/978-94-011-2666-3_16.Peer-Reviewed Original ResearchCoronary artery diseaseArtery diseaseEjection fractionPharmacological vasodilatationPhysical exerciseTl-201Regional wall motion studiesFirst-pass ejection fractionVentricular ejection fractionSize of infarctionAcute myocardial infarctionMyocardial perfusion imagingRegional wall motionMyocardial blood flowWall motion studiesThousands of patientsLower extraction fractionMyocardial salvageThrombolytic therapyVentricular functionCoronary occlusionMyocardial infarctionMyocardial ischemiaSestamibi imagingMyocardial viability
1990
Thrombolytic therapy for myocardial infarction: Assessment of efficacy by myocardial perfusion imaging with technetium-99m sestamibi
Wackers F. Thrombolytic therapy for myocardial infarction: Assessment of efficacy by myocardial perfusion imaging with technetium-99m sestamibi. The American Journal Of Cardiology 1990, 66: e36-e41. PMID: 2145744, DOI: 10.1016/0002-9149(90)90610-d.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorThrombolytic therapyMyocardial infarctionFirst acute myocardial infarctionInfarct-related artery patencyInitial risk areaPersistent coronary occlusionAcute chest painAcute myocardial infarctionAssessment of efficacyFuture clinical researchImaging agentNew thrombolytic agentsTissue-type plasminogen activatorArtery patencyChest painInfarct arterySuccessful thrombolysisConventional therapyCoronary occlusionHypoperfused myocardiumThrombolytic agentsMyocardial perfusionPatientsEnd point
1989
Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy
Wackers F, Gibbons R, Verani M, Kayden D, Pellikka P, Behrenbeck T, Mahmarian J, Zaret B. Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy. Journal Of The American College Of Cardiology 1989, 14: 861-873. PMID: 2507612, DOI: 10.1016/0735-1097(89)90456-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorAcute myocardial infarctionPatent infarct-related arteryInfarct-related arteryThallium-201 imagingThrombolytic therapyMyocardial infarctionPlanar technetiumMyocardial perfusionExercise thallium-201 imagingFirst acute myocardial infarctionInfarct-related artery patencyInitial risk areaPersistent coronary occlusionSuccess of reperfusionMyocardial blood flowNew myocardial perfusionTissue-type plasminogen activatorArtery patencyChest painCoronary occlusionRepeat imagingBlood flowInfarctionThallium-201