Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response
Serebrenik YV, Hellerschmied D, Toure M, López-Giráldez F, Brookner D, Crews CM. Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response. Molecular Biology Of The Cell 2018, 29: 1284-1298. PMID: 29851555, PMCID: PMC5994893, DOI: 10.1091/mbc.e17-11-0693.Peer-Reviewed Original ResearchMeSH KeywordsGene OntologyGolgi ApparatusHEK293 CellsHeLa CellsHumansHydrophobic and Hydrophilic InteractionsModels, BiologicalProtein StabilityProtein UnfoldingStress, PhysiologicalTranscription, GeneticConceptsStress responseTranscriptional stress responseChemical biology strategyStress response mechanismsGolgi structural integrityRNA sequence profilesUncharacterized genesEssential organellesEukaryotic cellsCellular homeostasisMisfolded proteinsGolgi targetingTranscriptional responseProtein substratesOrganelle structureProtein modificationHomeostasis mechanismsGolgi apparatusSecretory systemTargeted proteinsProtein unfoldingFurther revealsMajor siteProteinPrecise processing