2024
A Convolutional Neural Network Approach to Personalized Neuropil Density Prediction
Chang B, Akif A, Onofrey J, Hyder F. A Convolutional Neural Network Approach to Personalized Neuropil Density Prediction. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/4846.Peer-Reviewed Original ResearchConvolutional neural networkSuccess of machine learning methodsConvolutional neural network approachCell countNeural network approachMachine learning methodsNeural cell countNeural networkLearning methodsMetabolic imagingMulti-modal MRINetwork approachSynaptic densityPatient-specificBrain energeticsQuantify electrical activityNeural cellsEnergy budgetDensity predictionElectrical activityIn vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjects
2022
A 3D atlas of functional human brain energetic connectome based on neuropil distribution
Yu Y, Akif A, Herman P, Cao M, Rothman D, Carson R, Agarwal D, Evans A, Hyder F. A 3D atlas of functional human brain energetic connectome based on neuropil distribution. Cerebral Cortex 2022, 33: 3996-4012. PMID: 36104858, PMCID: PMC10068297, DOI: 10.1093/cercor/bhac322.Peer-Reviewed Original ResearchConceptsSynaptic densityCortical regionsHigher synapse densityHuman cortical circuitsFunctional imaging studiesCortical activity mapsVivo PET imagingNeuropil distributionGlucose oxidationSynapse densityCortical circuitsMetabolic rateSynaptic connectionsCortical energeticsImaging studiesHuman cortexPET imagingHistological stainingRecent evidenceCortexHuman brainBrainVoxel levelActivity ratesAtlas