2016
Apoptosis in response to microbial infection induces autoreactive TH17 cells
Campisi L, Barbet G, Ding Y, Esplugues E, Flavell RA, Blander JM. Apoptosis in response to microbial infection induces autoreactive TH17 cells. Nature Immunology 2016, 17: 1084-1092. PMID: 27455420, PMCID: PMC5079524, DOI: 10.1038/ni.3512.Peer-Reviewed Original Research
2003
CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis
Sancho D, Gómez M, Viedma F, Esplugues E, Gordón-Alonso M, García-López MA, de la Fuente H, Martínez-A C, Lauzurica P, Sánchez-Madrid F. CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis. Journal Of Clinical Investigation 2003, 112: 872-882. PMID: 12975472, PMCID: PMC193672, DOI: 10.1172/jci19112.Peer-Reviewed Original ResearchConceptsCollagen-induced arthritisCD69-/- miceAutoimmune reactivitySeverity of CIAProinflammatory cytokine mRNA levelsB cell immune responsesProinflammatory cytokines IL-1betaCD69-deficient miceRole of CD69Cell immune responsesCytokine mRNA levelsCytokines IL-1betaActivation of leukocytesTGF-beta1 productionNegative cell linesSplenocyte subsetsProinflammatory mediatorsBeta antibodyIL-1betaInflammatory fociLocal injectionSynovial leukocytesImmune responseCIA severityInflammatory sites