2010
CD69 limits early inflammatory diseases associated with immune response to Listeria monocytogenes infection
Vega‐Ramos J, Alari‐Pahissa E, del Valle J, Carrasco‐Marín E, Esplugues E, Borràs M, Martínez‐A C, Lauzurica P. CD69 limits early inflammatory diseases associated with immune response to Listeria monocytogenes infection. Immunology And Cell Biology 2010, 88: 707-715. PMID: 20440294, DOI: 10.1038/icb.2010.62.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteApoptosisDendritic CellsDNA-Binding ProteinsImmunity, InnateInflammationInterferon Type IInterferon-gammaLectins, C-TypeListeriosisLiverMacrophages, PeritonealMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutSpleenT-LymphocytesTransforming Growth Factor beta1ConceptsListeria monocytogenes infectionMonocytogenes infectionT cellsLM-specific T cellsEarly inflammatory diseaseInfection-induced immunopathologyPotent inflammatory responseBone marrow-derived macrophagesMarrow-derived macrophagesWild-type controlsDendritic cellsTh1 cytokinesImmune pathologyLM infectionInflammatory diseasesInflammatory responseImmune responseLymphocyte apoptosisHost protectionSpleen damageDay 1CD69Mouse infectionCell activationIFN enhancement
2003
Enhanced Antitumor Immunity in Mice Deficient in CD69
Esplugues E, Sancho D, Vega-Ramos J, Martínez-A C, Syrbe U, Hamann A, Engel P, Sánchez-Madrid F, Lauzurica P. Enhanced Antitumor Immunity in Mice Deficient in CD69. Journal Of Experimental Medicine 2003, 197: 1093-1106. PMID: 12732655, PMCID: PMC2193974, DOI: 10.1084/jem.20021337.Peer-Reviewed Original ResearchConceptsAnti-tumor responseCD69-/- miceEnhanced anti-tumor responseWT miceMHC class I- tumorsT cell productionTGF-beta productionChemokine MCP-1Wild-type miceTGF-beta regulationLocal lymphocytesAntitumor immunityVivo blockadeNK cellsAntibody treatmentI tumorsMCP-1CD69 expressionLymphocyte apoptosisMice DeficientTherapy of tumorsTumor growthCD69MiceVivo role