2023
SARS-CoV-2-encoded small RNAs are able to repress the host expression of SERINC5 to facilitate viral replication
Meseguer S, Rubio M, Lainez B, Pérez-Benavente B, Pérez-Moraga R, Romera-Giner S, García-García F, Martinez-Macias O, Cremades A, Iborra F, Candelas-Rivera O, Almazan F, Esplugues E. SARS-CoV-2-encoded small RNAs are able to repress the host expression of SERINC5 to facilitate viral replication. Frontiers In Microbiology 2023, 14: 1066493. PMID: 36876111, PMCID: PMC9978209, DOI: 10.3389/fmicb.2023.1066493.Peer-Reviewed Original ResearchViral infectionSARS-CoV-2 viral infectionSARS-CoV-2 infectionCOVID-19 patientsMitochondrial antiviral signaling proteinInnate immunity factorsInnate immune responseVero E6 cellsSARS-CoV-2Viral proteinsImmune responseE6 cellsTherapeutic potentialViral replicationInfectionVero E6Immunity factorsSmall viral RNAsCertain virusesProtein 5SERINC5 expressionViral RNAHost expressionDifferent virusesVirus
2011
Development of Autoimmune Diabetes in the Absence of Detectable IL-17A in a CD8-Driven Virally Induced Model
Van Belle TL, Esplugues E, Liao J, Juntti T, Flavell RA, von Herrath MG. Development of Autoimmune Diabetes in the Absence of Detectable IL-17A in a CD8-Driven Virally Induced Model. The Journal Of Immunology 2011, 187: 2915-2922. PMID: 21832162, PMCID: PMC3169711, DOI: 10.4049/jimmunol.1000180.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell SeparationDiabetes Mellitus, Type 1Disease Models, AnimalFemaleFlow CytometryGene Knock-In TechniquesGenes, ReporterGreen Fluorescent ProteinsInterleukin-17Lymphocytic choriomeningitis virusMaleMiceMice, Inbred C57BLVirus DiseasesConceptsType 1 diabetesIL-17AIL-17IL-17A.T cellsViral infectionAutoimmune diabetes developmentVirus-induced modelIL-17 levelsIL-17A productionΓδ T cellsLymphocytic choriomeningitis virusAutoimmune diabetesAutoimmune disordersChronic inflammationDiabetes developmentViral eliminationReporter miceDiabetesBacterial infectionsInfectionCD8Recent studiesCellsInflammationControl of TH17 cells occurs in the small intestine
Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O’Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. Control of TH17 cells occurs in the small intestine. Nature 2011, 475: 514-518. PMID: 21765430, PMCID: PMC3148838, DOI: 10.1038/nature10228.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesCD3 ComplexCD4-Positive T-LymphocytesCell MovementChemokine CCL20Disease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleGene Expression ProfilingGene Expression RegulationInfluenza A virusInterleukin-17Intestine, SmallMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicOrthomyxoviridae InfectionsReceptors, CCR6SepsisStaphylococcal InfectionsTh17 CellsConceptsTh17 cellsImmune systemSmall intestineCD3-specific antibodiesT helper cellsModel of sepsisNumerous autoimmune diseasesRheumatoid arthritisMultiple sclerosisAutoimmune diseasesHelper cellsGastrointestinal tractViral infectionIntestineCellsSepsisTh17ArthritisSclerosisPathogenesisInfectionInfluenzaDiseaseMiceTract