CD84 Functions as a Homophilic Adhesion Molecule and Enhances IFN-γ Secretion: Adhesion Is Mediated by Ig-Like Domain 1
Martin M, Romero X, de la Fuente M, Tovar V, Zapater N, Esplugues E, Pizcueta P, Bosch J, Engel P. CD84 Functions as a Homophilic Adhesion Molecule and Enhances IFN-γ Secretion: Adhesion Is Mediated by Ig-Like Domain 1. The Journal Of Immunology 2001, 167: 3668-3676. PMID: 11564780, DOI: 10.4049/jimmunol.167.7.3668.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntigens, CDBinding, CompetitiveCell AdhesionCell Adhesion MoleculesCells, CulturedChildChild, PreschoolCOS CellsHumansImmunoglobulinsInterferon-gammaLymphocyte ActivationMembrane GlycoproteinsMiceProtein Structure, TertiarySignaling Lymphocytic Activation Molecule FamilyThymus GlandT-LymphocytesTumor Cells, CulturedConceptsFusion proteinExtracellular domainSoluble Ig fusion proteinDomain 1Homophilic adhesion moleculeFirst extracellular domainLymphoproliferative disease geneReceptor-ligand interactionsIg-like domains 1Cytoplasmic tailProtein 1ADisease genesCell surface moleculesHuman CD84Ligand-receptor recognitionCD2 familyMature T cellsCD84Own ligandConcurrent ligationMouse chimerasReceptor recognitionIg fusion proteinProteinCell maturation