CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis
Sancho D, Gómez M, Viedma F, Esplugues E, Gordón-Alonso M, García-López MA, de la Fuente H, Martínez-A C, Lauzurica P, Sánchez-Madrid F. CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis. Journal Of Clinical Investigation 2003, 112: 872-882. PMID: 12975472, PMCID: PMC193672, DOI: 10.1172/jci19112.Peer-Reviewed Original ResearchConceptsCollagen-induced arthritisCD69-/- miceAutoimmune reactivitySeverity of CIAProinflammatory cytokine mRNA levelsB cell immune responsesProinflammatory cytokines IL-1betaCD69-deficient miceRole of CD69Cell immune responsesCytokine mRNA levelsCytokines IL-1betaActivation of leukocytesTGF-beta1 productionNegative cell linesSplenocyte subsetsProinflammatory mediatorsBeta antibodyIL-1betaInflammatory fociLocal injectionSynovial leukocytesImmune responseCIA severityInflammatory sitesEnhanced Antitumor Immunity in Mice Deficient in CD69
Esplugues E, Sancho D, Vega-Ramos J, Martínez-A C, Syrbe U, Hamann A, Engel P, Sánchez-Madrid F, Lauzurica P. Enhanced Antitumor Immunity in Mice Deficient in CD69. Journal Of Experimental Medicine 2003, 197: 1093-1106. PMID: 12732655, PMCID: PMC2193974, DOI: 10.1084/jem.20021337.Peer-Reviewed Original ResearchConceptsAnti-tumor responseCD69-/- miceEnhanced anti-tumor responseWT miceMHC class I- tumorsT cell productionTGF-beta productionChemokine MCP-1Wild-type miceTGF-beta regulationLocal lymphocytesAntitumor immunityVivo blockadeNK cellsAntibody treatmentI tumorsMCP-1CD69 expressionLymphocyte apoptosisMice DeficientTherapy of tumorsTumor growthCD69MiceVivo role