2006
CD69 targeting differentially affects the course of collagen-induced arthritis
Sancho D, Gómez M, del Hoyo G, Lamana A, Esplugues E, Lauzurica P, Martinez-A C, Sánchez-Madrid F. CD69 targeting differentially affects the course of collagen-induced arthritis. Journal Of Leukocyte Biology 2006, 80: 1233-1241. PMID: 16921025, DOI: 10.1189/jlb.1205749.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAntibodies, MonoclonalAntigens, CDAntigens, Differentiation, T-LymphocyteArthritis, ExperimentalCell ProliferationCollagen Type IIImmunoglobulin GInflammationInterferon-gammaLectins, C-TypeLymphocyte DepletionMiceMice, Inbred BALB CMice, Inbred DBAMice, KnockoutT-LymphocytesConceptsCollagen-induced arthritisCII-specific T cellsLymphocyte proliferative responsesChronic inflammatory diseaseActivation of leukocytesWild-type animalsInflammation correlatesAdoptive transferDBA/1 miceProinflammatory cytokinesInflammatory diseasesInflammatory fociCD69 expressionCD69 mAbT cellsImmune responseIFN-gammaInflammatory sitesProliferative responseCD69Type II collagenArthritisDecreased productionDiseaseMice
2005
Induction of tumor NK-cell immunity by anti-CD69 antibody therapy
Esplugues E, Vega-Ramos J, Cartoixà D, Vazquez BN, Salaet I, Engel P, Lauzurica P. Induction of tumor NK-cell immunity by anti-CD69 antibody therapy. Blood 2005, 105: 4399-4406. PMID: 15692061, DOI: 10.1182/blood-2004-10-3854.Peer-Reviewed Original ResearchConceptsAntitumor responseNK cell cytolytic activityMonoclonal antibodiesCD69 monoclonal antibodiesNK cell immunityNK cytotoxic activityInterferon-gamma productionTGF-beta productionActivation marker CD69Production of cytokinesInnate immune systemReceptor-independent mannerNK cellsAntibody therapyLung metastasesCD69 expressionTherapeutic administrationCD69 mAbImmune responseCytolytic activityGamma productionImmune systemTumor growthTumor primingCD69