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INFORMATION FOR

    Emmanuelle Schindler, MD, PhD

    Assistant Professor
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    Additional Titles

    Medical Director, Headache Center of Excellence, VA Connecticut Healthcare System

    About

    Titles

    Assistant Professor

    Positions outside Yale

    Medical Director, Headache Center of Excellence, VA Connecticut Healthcare System

    Biography

    Among my efforts to optimize the management of headache disorders, I have developed and executed the first controlled trials investigating the effects and mechanisms of action of psilocybin in cluster, migraine, and post-traumatic headache. Previously, I studied the neuropharmacology of psychedelics and other serotonergic compounds in the context of receptor binding and intracellular signaling. Currently, I’m seeking to identify the source of sustained reductions in headache burden after limited dosing of psychedelic and related compounds, considering several neurobiological systems involved in both headache pathology and the known actions of psychedelic compounds.

    Another endeavor of mine is to enhance the understanding of and improve the lives of patients with cluster headache, a severely painful headache disorder also known as “suicide headache.” Recognition and proper management of this condition is woefully lacking. While novel therapies are finally emerging, further research is desperately needed. In addition to better treatments, basic gold-standard therapies, such as inhaled oxygen, remain out of reach for many patients. Education on many levels, including federal regulatory bodies, is required to best serve this patient population that itself has demonstrated immense resilience and optimism in the face of their disease.

    Appointments

    Education & Training

    Advanced Research Fellow
    VA Connecticut Healthcare System (2018)
    Resident
    Yale School of Medicine (2016)
    MD
    Drexel University College of Medicine (2012)
    PhD
    Drexel University College of Medicine, Neuroscience (2010)
    BS
    College of William & Mary, Biological Psychiatry (2003)

    Research

    Overview

    Medical Research Interests

    Cluster Headache; Migraine Disorders; Post-Traumatic Headache

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Emmanuelle Schindler's published research.

    Publications

    2025

    2024

    2023

    Academic Achievements & Community Involvement

    • activity

      American Academy of Neurology

    • activity

      American Headache Society

    • activity

      International Headache Society

    • activity

      International Society for Research on Psychedelics

    • honor

      Kindness Award

    Clinical Care

    Overview

    Emmanuelle Schindler, MD, PhD, is a neurologist focused on the management of headache disorders, with a particular interest in cluster headache.

    “The pain associated with cluster headache is rated higher than other painful states, such as childbirth or passing a kidney stone,” Dr. Schindler says. “And the headaches themselves can happen multiple times a day, nonstop for years on end, which makes it an important headache to manage and improve treatment for.”

    Unfortunately, people with cluster headache are often misdiagnosed as having another headache disorder, such as migraine or sinus headache, and treatments they have tried are not effective, Dr. Schindler adds.

    One of the best parts of her job, Dr. Schindler says, is bringing headache patients relief from pain. “If you help lower a patient’s blood pressure or blood sugar, they might not thank you because it meant they had to stop eating their favorite foods, for example,” she says. “But even if I reduce a patient’s number of headaches by 25% to 30%, they are extremely grateful because it makes a huge difference in their life and allows them to get back to work or return to social activities instead of isolating themselves.”

    An active researcher, she is exploring how limited dosing of psilocybin (a psychedelic that comes from so-called “magic mushrooms”) can help in the management of cluster, migraine, and post-traumatic headache (those that occur within days of a head injury).

    Her research provides even more promise for better treatments for her patients. “It’s exciting to be studying a completely new way of treating headache disorders. I want to help those for whom existing treatments aren’t quite working for them,” Dr. Schindler says.

    Clinical Specialties

    Neurology

    Board Certifications

    • Neurology

      Certification Organization
      AB of Psychiatry & Neurology
    • Headache Medicine

      Certification Organization
      United Council for Neurologic Subspecialties

    Get In Touch

    Contacts

    Locations

    • Patient Care Locations

      Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.