2020
Response to “Trials for depressive disorder in adolescents: the emperor's new clothes,” a letter to the editor by Alain Braillon, MD, PhD
Butcher N, Mew E, Monsour A, Szatmari P, Monga S, Offringa M, co-authors A. Response to “Trials for depressive disorder in adolescents: the emperor's new clothes,” a letter to the editor by Alain Braillon, MD, PhD. Journal Of Clinical Epidemiology 2020, 128: 159-161. PMID: 32860976, PMCID: PMC7449977, DOI: 10.1016/j.jclinepi.2020.08.010.Peer-Reviewed Original ResearchSystematic scoping review identifies heterogeneity in outcomes measured in adolescent depression clinical trials
Mew E, Monsour A, Saeed L, Santos L, Patel S, Courtney D, Watson P, Szatmari P, Offringa M, Monga S, Butcher N. Systematic scoping review identifies heterogeneity in outcomes measured in adolescent depression clinical trials. Journal Of Clinical Epidemiology 2020, 126: 71-79. PMID: 32561367, DOI: 10.1016/j.jclinepi.2020.06.013.Peer-Reviewed Original ResearchConceptsOutcome measurement instrumentsOutcome heterogeneityMajor depressive disorder trialsMajor depressive disorderDepressive symptom severityOutcome termsSingle trialDepression clinical trialPrimary outcomeClinical trialsDepressive disorderDepression trialsSymptom severityLife impactStudy designIdentified outcomesTrial resultsTrialsOutcomesIdentifies heterogeneityDescriptive analysisMeasurement instrumentsTherapySeverityPrimary outcome reporting in adolescent depression clinical trials needs standardization
Monsour A, Mew E, Patel S, Chee-a-tow A, Saeed L, Santos L, Courtney D, Watson P, Monga S, Szatmari P, Offringa M, Butcher N. Primary outcome reporting in adolescent depression clinical trials needs standardization. BMC Medical Research Methodology 2020, 20: 129. PMID: 32450810, PMCID: PMC7247139, DOI: 10.1186/s12874-020-01019-6.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsPrimary outcomeSingle primary outcomeClinical trialsOutcome assessmentDiagnosis of MDDChecklist itemsOutcome assessorsDepression clinical trialClinical guidelinesAdolescent MDDOutcome analysisRCT publicationsMost trialsTrial publicationsOutcome reportingReporting ItemsTreatment interventionsTrial outcomesOutcome informationTrialsHealth careOutcomesSignificant differencesMinimal criteria
2019
Improving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT)
Butcher NJ, Monsour A, Mew EJ, Szatmari P, Pierro A, Kelly LE, Farid-Kapadia M, Chee-a-tow A, Saeed L, Monga S, Ungar W, Terwee CB, Vohra S, Fergusson D, Askie LM, Williamson PR, Chan AW, Moher D, Offringa M. Improving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT). Trials 2019, 20: 161. PMID: 30841935, PMCID: PMC6404348, DOI: 10.1186/s13063-019-3248-0.Peer-Reviewed Original ResearchConceptsClinical trialsTrial protocolTrial reportsExpert consensus meetingClinical trial reportsCONSORT reporting guidelinesIntegrated knowledge translation approachSystematic review authorsKnowledge translation approachReview authorsConsensus-based standardsPatient outcomesConsensus meetingDiverse disease areasInternational Delphi studyTrial designGuideline developersGuideline developmentCONSORT extensionDelphi studyTrial outcomesEQUATOR NetworkCandidate outcomesTrialsPoor quality outcomes