2024
Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support
Radford M, Estcourt L, Sirotich E, Pitre T, Britto J, Watson M, Brunskill S, Fergusson D, Dorée C, Arnold D. Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support. 2024, 2024: cd011305. PMID: 38780066, PMCID: PMC11112982, DOI: 10.1002/14651858.cd011305.pub3.Peer-Reviewed Original ResearchConceptsRed blood cell transfusion strategyHaematopoietic stem cell transplantationLiberal transfusion strategyClinically significant bleedingRestrictive transfusion strategyNon-randomised studiesTransfusion strategyIntensive chemotherapyRandomised controlled trialsRed blood cellsSignificant bleedingAll-cause mortalityLength of hospital admissionAcute leukemiaHaematological malignanciesRisk of clinically significant bleedingHaematopoietic stem cell supportProspective non-randomised studyRisk ratioControlled trialsQuality of lifeStem cell supportStem cell transplantationMalignant haematological disordersCochrane Central Register of Controlled Trials
2023
“I’d like more options!”: Interviews to explore young people and family decision-making needs for pain management in juvenile idiopathic arthritis
Toupin-April K, Gaboury I, Proulx L, Huber A, Duffy C, Morgan E, Li L, Stringer E, Connelly M, Weiss J, Gibbon M, Sachs H, Sivakumar A, Sirois A, Sirotich E, Trehan N, Abrahams N, Cohen J, Cavallo S, Hindi T, Ragusa M, Légaré F, Brinkman W, Fortin P, Décary S, Lee R, Gmuca S, Paterson G, Tugwell P, Stinson J. “I’d like more options!”: Interviews to explore young people and family decision-making needs for pain management in juvenile idiopathic arthritis. Pediatric Rheumatology 2023, 21: 74. PMID: 37491246, PMCID: PMC10369758, DOI: 10.1186/s12969-023-00849-0.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentArthritis, JuvenileChildDecision Making, SharedHumansPainPain ManagementQualitative ResearchQuality of LifeConceptsPain management optionsHealth care providersParents/caregiversPain managementIdiopathic arthritisPediatric health care providersBackgroundJuvenile idiopathic arthritisPain management discussionsPediatric rheumatic conditionsOttawa Decision Support FrameworkHealth-related qualityJuvenile idiopathic arthritisQualitative descriptive study designYears of ageDecision support interventionsBetter health outcomesDescriptive study designEvidence-based informationManagement optionsQuality improvement networkRheumatology nursesRheumatology consultationJoint painHCP trainingNonpharmacological approachesImpact of iron supplementation on patient outcomes for women with abnormal uterine bleeding: a protocol for a systematic review and meta-analysis
Nazaryan H, Watson M, Ellingham D, Thakar S, Wang A, Pai M, Liu Y, Rochwerg B, Gabarin N, Arnold D, Sirotich E, Zeller M. Impact of iron supplementation on patient outcomes for women with abnormal uterine bleeding: a protocol for a systematic review and meta-analysis. Systematic Reviews 2023, 12: 121. PMID: 37443063, PMCID: PMC10347734, DOI: 10.1186/s13643-023-02222-4.Peer-Reviewed Original ResearchConceptsIron deficiency anemiaQuality of lifeHeavy menstrual bleedingStandard of carePatient outcomesIron interventionsSystematic reviewUterine bleedingCombination therapyIron supplementationIron indicesRed blood cell transfusionIron deficiencyRed blood cell utilizationAbnormal uterine bleedingIntraoperative blood lossBlood cell transfusionEvidence-based clinical practiceMeta-analyzed outcomesSystematic literature searchCost of treatmentWeb of ScienceCell transfusionHospital stayAdverse events
2021
Health-Related Quality-of-Life and Cost Utility Analyses in Critical Care: A Systematic Review.
Lau V, Xie F, Basmaji J, Cook D, Fowler R, Kiflen M, Sirotich E, Iansavichene A, Bagshaw S, Wilcox M, Lamontagne F, Ferguson N, Rochwerg B. Health-Related Quality-of-Life and Cost Utility Analyses in Critical Care: A Systematic Review. Critical Care Medicine 2021, 49: 575-588. PMID: 33591013, DOI: 10.1097/ccm.0000000000004851.Peer-Reviewed Original ResearchMeSH KeywordsCost-Benefit AnalysisCritical CareHumansIntensive Care UnitsQuality of LifeQuality-Adjusted Life YearsConceptsCost-utility analysisQuality-adjusted life yearsUtility analysisLife yearsNational Health Service Economic Evaluation DatabaseUK National Health Service Economic Evaluation DatabaseCost utilityUtility measuresEconomic Evaluation DatabaseHealth-related qualityHealth utility measuresCritical careTime horizonEvaluation DatabaseIncremental costUtility reportingSystematic reviewFuture cost-utility analysesQuantity of lifeBaseline health-related qualityPhysicians Journal ClubDatabase of AbstractsCostReviews of EffectsAnalyse studies