2024
Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review
Chowdhury S, Sirotich E, Guyatt G, Gill D, Modi D, Venier L, Mahamad S, Chowdhury M, Eisa K, Beck C, Breakey V, de Wit K, Porter S, Webert K, Cuker A, O'Connor C, ‐DiRaimo J, Yan J, Manski C, Kelton J, Kang M, Strachan G, Hassan Z, Pruitt B, Pai M, Grace R, Paynter D, Charness J, Cooper N, Fein S, Agarwal A, Nazaryan H, Siddiqui I, Leong R, Pallapothu S, Wen A, Xu E, Liu B, Shafiee A, Rathod P, Kwon H, Dookie J, Zeraatkar D, Thabane L, Couban R, Arnold D. Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review. European Journal Of Haematology 2024 PMID: 39552264, DOI: 10.1111/ejh.14351.Peer-Reviewed Original ResearchImmune thrombocytopeniaCritical bleedingTPO-RAsPlatelet transfusionsCritically bleeding patientsPlatelet count responseSystematic reviewReview of treatmentBleeding patientsIVIGEvidence-based protocolsBleedingBleeding emergenciesCorticosteroidsSystematic review of treatmentsPatientsSplenectomyPatient outcomesIndividualized treatmentThrombocytopeniaPlateletTransfusionEffects of individual treatmentsTreatmentStudy designTreatment of critical bleeding events in patients with immune thrombocytopenia: a protocol for a systematic review and meta-analysis
Sirotich E, Nazaryan H, Chowdhury S, Guyatt G, Agarwal A, Leong R, Wen A, Xu E, Liu B, Pallapothu S, Rathod P, Kwon H, Dookie J, Shafiee A, Charness J, DiRaimo J, Paynter D, Pruitt B, Strachan G, Couban R, Ye Z, Arnold D. Treatment of critical bleeding events in patients with immune thrombocytopenia: a protocol for a systematic review and meta-analysis. Systematic Reviews 2024, 13: 21. PMID: 38184622, PMCID: PMC10770981, DOI: 10.1186/s13643-023-02436-6.Peer-Reviewed Original ResearchConceptsCritical bleedingSystematic reviewEvidence-based treatment protocolsBleeding-related mortalityCochrane Central RegisterEvidence-based recommendationsFull-text screeningBleeding eventsImmune thrombocytopeniaRecommendations AssessmentCentral RegisterControlled TrialsPrimary outcomeSevere thrombocytopeniaPlatelet countEligible studiesPatient outcomesEmergency settingOvid MEDLINEObservational studyTreatment protocolHigh riskMedical emergencyElectronic databasesMethodsLiterature search
2023
Treatment of Critical Bleeding Events in Patients with Immune Thrombocytopenia: A Systematic Review
Sirotich E, Chowdhury S, Guyatt G, Gill D, Modi D, Venier L, Eisa K, Beck C, Breakey V, de Wit K, Porter S, Webert K, Cuker A, O'Connor C, DiRaimo J, Yan J, Manski C, Kelton J, Kang M, Strachan G, Hassan Z, Pruitt B, Pai M, Grace R, Paynter D, Charness J, Cooper N, Fein S, Nazaryan H, Agarwal A, Siddiqui I, Leong R, Pallapothu S, Wen A, Xu E, Liu B, Rathod P, Kwon H, Dookie J, Shafiee A, Couban R, Arnold D. Treatment of Critical Bleeding Events in Patients with Immune Thrombocytopenia: A Systematic Review. Blood 2023, 142: 7239. DOI: 10.1182/blood-2023-179448.Peer-Reviewed Original ResearchPlatelet count responseTPO-RAsImmune thrombocytopeniaPlatelet transfusionsCritical bleedingBleed resolutionTreated with platelet transfusionsPatients treated with splenectomyControlled trialsCritical bleeding eventsManagement of critical bleedingTPO receptor agonistsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsSystematic reviewTreatment of critical bleedingCochrane Central RegisterReview of treatmentEvidence-based treatment protocolsClinical practice guidelinesRandomized controlled trialsCount responseIntraperitoneal bleedingOcular bleedingImpact of iron supplementation on patient outcomes for women with abnormal uterine bleeding: a protocol for a systematic review and meta-analysis
Nazaryan H, Watson M, Ellingham D, Thakar S, Wang A, Pai M, Liu Y, Rochwerg B, Gabarin N, Arnold D, Sirotich E, Zeller M. Impact of iron supplementation on patient outcomes for women with abnormal uterine bleeding: a protocol for a systematic review and meta-analysis. Systematic Reviews 2023, 12: 121. PMID: 37443063, PMCID: PMC10347734, DOI: 10.1186/s13643-023-02222-4.Peer-Reviewed Original ResearchConceptsIron deficiency anemiaQuality of lifeHeavy menstrual bleedingStandard of carePatient outcomesIron interventionsSystematic reviewUterine bleedingCombination therapyIron supplementationIron indicesRed blood cell transfusionIron deficiencyRed blood cell utilizationAbnormal uterine bleedingIntraoperative blood lossBlood cell transfusionEvidence-based clinical practiceMeta-analyzed outcomesSystematic literature searchCost of treatmentWeb of ScienceCell transfusionHospital stayAdverse events
2021
Assessments of risk of bias in systematic reviews of observational nutritional epidemiologic studies are often not appropriate or comprehensive: a methodological study
Zeraatkar D, Kohut A, Bhasin A, Morassut R, Churchill I, Gupta A, Lawson D, Miroshnychenko A, Sirotich E, Aryal K, Azab M, Beyene J, de Souza R. Assessments of risk of bias in systematic reviews of observational nutritional epidemiologic studies are often not appropriate or comprehensive: a methodological study. BMJ Nutrition Prevention & Health 2021, 4: e000248. PMID: 35028518, PMCID: PMC8718856, DOI: 10.1136/bmjnph-2021-000248.Peer-Reviewed Original ResearchCharacteristics and quality of systematic reviews and meta-analyses of observational nutritional epidemiology: a cross-sectional study
Zeraatkar D, Bhasin A, Morassut R, Churchill I, Gupta A, Lawson D, Miroshnychenko A, Sirotich E, Aryal K, Mikhail D, Khan T, Ha V, Sievenpiper J, Hanna S, Beyene J, de Souza R. Characteristics and quality of systematic reviews and meta-analyses of observational nutritional epidemiology: a cross-sectional study. American Journal Of Clinical Nutrition 2021, 113: 1578-1592. PMID: 33740039, PMCID: PMC8243916, DOI: 10.1093/ajcn/nqab002.Peer-Reviewed Original ResearchConceptsCertainty of evidenceSystematic reviewNutritional epidemiology studiesEpidemiology studiesDose-response associationPoor methodological qualityCross-sectional studyRigorous systematic reviewOne-quarterCochrane DatabaseNonrandomized studyCancer morbidityDietary recommendationsMethodological qualityNutritional exposuresNutritional epidemiologyReplicable search strategySuboptimal practicesMeta-analytic modelOne-thirdRandom sampleMost reviewsReviewMethodological evaluationNutritionHealth-Related Quality-of-Life and Cost Utility Analyses in Critical Care: A Systematic Review.
Lau V, Xie F, Basmaji J, Cook D, Fowler R, Kiflen M, Sirotich E, Iansavichene A, Bagshaw S, Wilcox M, Lamontagne F, Ferguson N, Rochwerg B. Health-Related Quality-of-Life and Cost Utility Analyses in Critical Care: A Systematic Review. Critical Care Medicine 2021, 49: 575-588. PMID: 33591013, DOI: 10.1097/ccm.0000000000004851.Peer-Reviewed Original ResearchConceptsCost-utility analysisQuality-adjusted life yearsUtility analysisLife yearsNational Health Service Economic Evaluation DatabaseUK National Health Service Economic Evaluation DatabaseCost utilityUtility measuresEconomic Evaluation DatabaseHealth-related qualityHealth utility measuresCritical careTime horizonEvaluation DatabaseIncremental costUtility reportingSystematic reviewFuture cost-utility analysesQuantity of lifeBaseline health-related qualityPhysicians Journal ClubDatabase of AbstractsCostReviews of EffectsAnalyse studies
2019
Impact of Iron Supplementation on Patient Outcomes in Women Undergoing Gynecological Procedures: Systematic Review and Meta-Analysis of Randomized Trials
Sirotich E, Jamula E, Wang A, Arnold D, Zeller M. Impact of Iron Supplementation on Patient Outcomes in Women Undergoing Gynecological Procedures: Systematic Review and Meta-Analysis of Randomized Trials. Blood 2019, 134: 59. DOI: 10.1182/blood-2019-122269.Peer-Reviewed Original ResearchPerioperative RBC transfusionPreoperative Hb levelErythropoietin-stimulating agentsRBC transfusion ratesAdverse eventsIron supplementationGynecological proceduresRBC transfusionPatient outcomesHb levelsSystematic reviewPostoperative HbTransfusion rateHemoglobin levelsIron supplementsPerioperative red blood cell transfusionIncidence of AEsOccurrence of AEsRed blood cell transfusionNumber of AEsPatient blood management strategiesPostoperative Hb levelsPreoperative iron supplementationBlood cell transfusionRisk of anemia
2017
Longitudinal studies that use data collected as part of usual care risk reporting biased results: a systematic review
Farzanfar D, Abumuamar A, Kim J, Sirotich E, Wang Y, Pullenayegum E. Longitudinal studies that use data collected as part of usual care risk reporting biased results: a systematic review. BMC Medical Research Methodology 2017, 17: 133. PMID: 28877680, PMCID: PMC5588621, DOI: 10.1186/s12874-017-0418-1.Peer-Reviewed Original ResearchConceptsUsual careVisit timeSystematic reviewLongitudinal studyCare risksPart of patientsOutcomes of interestTotal followEmbase databasesNumber of visitsEligible articlesLack of needLack of awarenessPatientsImportant predictorVisitsLack of useCareLower proportionRiskPredictorsReviewMEDLINEFollowStudy