2024
Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support
Radford M, Estcourt L, Sirotich E, Pitre T, Britto J, Watson M, Brunskill S, Fergusson D, Dorée C, Arnold D. Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support. 2024, 2024: cd011305. PMID: 38780066, PMCID: PMC11112982, DOI: 10.1002/14651858.cd011305.pub3.Peer-Reviewed Original ResearchConceptsRed blood cell transfusion strategyHaematopoietic stem cell transplantationLiberal transfusion strategyClinically significant bleedingRestrictive transfusion strategyNon-randomised studiesTransfusion strategyIntensive chemotherapyRandomised controlled trialsRed blood cellsSignificant bleedingAll-cause mortalityLength of hospital admissionAcute leukemiaHaematological malignanciesRisk of clinically significant bleedingHaematopoietic stem cell supportProspective non-randomised studyRisk ratioControlled trialsQuality of lifeStem cell supportStem cell transplantationMalignant haematological disordersCochrane Central Register of Controlled Trials
2023
Restrictive Versus Liberal Red Blood Cell Transfusion Strategies for Patients with Hematologic Malignancies Receiving Intensive Chemotherapy
Radford M, Watson M, Sirotich E, Pitre T, Britto J, Brunskill S, Fergusson D, Arnold D, Estcourt L. Restrictive Versus Liberal Red Blood Cell Transfusion Strategies for Patients with Hematologic Malignancies Receiving Intensive Chemotherapy. Blood 2023, 142: 5573. DOI: 10.1182/blood-2023-180430.Peer-Reviewed Original ResearchRed blood cell transfusion strategyHematopoietic stem cell transplantationLiberal transfusion strategyRestrictive transfusion strategyTransfusion strategyRed blood cellsCertainty of evidenceIntensive chemotherapyHematologic malignanciesRisk ratioRed blood cell transfusionConfidence intervalsMean differenceRed blood cell unitsRed blood cell usageClinically significant bleedingCochrane's standard methodological proceduresStem cell transplantationMalignant hematological disordersCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsLow hemoglobin levelRegister of Controlled TrialsReview's primary outcomesCochrane Central Register