2023
Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People With Rheumatic Diseases: A Comparative Analysis of Pandemic Epochs Using the COVID‐19 Global Rheumatology Alliance Registry
Yazdany J, Ware A, Wallace Z, Bhana S, Grainger R, Hachulla E, Richez C, Cacoub P, Hausmann J, Liew J, Sirotich E, Jacobsohn L, Strangfeld A, Mateus E, Hyrich K, Gossec L, Carmona L, Lawson‐Tovey S, Kearsley‐Fleet L, Schaefer M, Ribeiro S, Al‐Emadi S, Hasseli R, Müller‐Ladner U, Specker C, Schulze‐Koops H, Bernardes M, Fraga V, Rodrigues A, Sparks J, Ljung L, Di Giuseppe D, Tidblad L, Wise L, Duarte‐García A, Ugarte‐Gil M, Colunga‐Pedraza I, Martínez‐Martínez M, Alpizar‐Rodriguez D, Xavier R, Isnardi C, Pera M, Pons‐Estel G, Izadi Z, Gianfrancesco M, Carrara G, Scirè C, Zanetti A, Machado P. Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People With Rheumatic Diseases: A Comparative Analysis of Pandemic Epochs Using the COVID‐19 Global Rheumatology Alliance Registry. Arthritis Care & Research 2023, 76: 274-287. PMID: 37643903, DOI: 10.1002/acr.25220.Peer-Reviewed Original ResearchB-cell depleting therapySevere COVID-19Rheumatic diseasesCOVID-19 outcomesUnvaccinated peopleRisk factorsWorse outcomesCOVID-19Severe COVID-19 outcomesTumor necrosis factor inhibitorsHigh disease activityNecrosis factor inhibitorsConnective tissue diseaseCOVID-19 severityCOVID-19 vaccineThird of individualsLogistic regression modelsCOVID-19 diagnosisOrdinal logistic regression modelsLow HDI regionsMore comorbiditiesUnvaccinated patientsDisease activityUnvaccinated individualsFactor inhibitorsOmicron variant infection in inflammatory rheumatological conditions – outcomes from a COVID-19 naive population in Aotearoa New Zealand
Brooks J, Montgomery A, Dalbeth N, Sapsford M, Kee R, Cooper A, Quincey V, Bhana S, Gore-Massy M, Hausmann J, Liew J, Machado P, Sufka P, Sirotich E, Robinson P, Wallace Z, Yazdany J, Grainger R. Omicron variant infection in inflammatory rheumatological conditions – outcomes from a COVID-19 naive population in Aotearoa New Zealand. The Lancet Regional Health - Western Pacific 2023, 38: 100843. PMID: 37520279, PMCID: PMC10372177, DOI: 10.1016/j.lanwpc.2023.100843.Peer-Reviewed Original ResearchInflammatory rheumatic diseasesSARS-CoV-2 infectionHospitalisation/deathOmicron variant infectionConnective tissue diseaseRheumatic diseasesVariant infectionCOVID-19SARS-CoV-2 Omicron variantSingle vaccine doseCOVID-19 hospitalisationMultivariable adjusted modelsCOVID-19 vaccination statusMultivariable logistic regressionCOVID-19 vaccinationHigh vaccination ratesRituximab useVaccine doseInflammatory arthritisVaccination statusClinical factorsTissue diseaseDisease characteristicsVaccination ratesRisk factors
2022
Characteristics and Outcomes of People With Gout Hospitalized Due to COVID‐19: Data From the COVID‐19 Global Rheumatology Alliance Physician‐Reported Registry
Jatuworapruk K, Montgomery A, Gianfrancesco M, Conway R, Durcan L, Graef E, Jayatilleke A, Keen H, Kilian A, Young K, Carmona L, Cogo A, Duarte‐García A, Gossec L, Hasseli R, Hyrich K, Langlois V, Lawson‐Tovey S, Malcata A, Mateus E, Schafer M, Scirè C, Sigurdardottir V, Sparks J, Strangfeld A, Xavier R, Bhana S, Gore‐Massy M, Hausmann J, Liew J, Sirotich E, Sufka P, Wallace Z, Machado P, Yazdany J, Grainger R, Robinson P. Characteristics and Outcomes of People With Gout Hospitalized Due to COVID‐19: Data From the COVID‐19 Global Rheumatology Alliance Physician‐Reported Registry. ACR Open Rheumatology 2022, 4: 948-953. PMID: 36000538, PMCID: PMC9539246, DOI: 10.1002/acr2.11495.Peer-Reviewed Original ResearchMore comorbiditiesVentilatory supportPoor outcomeCOVID-19COVID-19-related deathsChronic kidney diseasePresence of comorbiditiesCohort of peopleCOVID-19 outcomesCoronavirus disease 2019Outcomes of peopleMedication exposureOverall cohortVentilation supportDiabetes mellitusSupplemental oxygenKidney diseaseMean ageRisk factorsCardiovascular diseaseDisease 2019ComorbiditiesGoutCohortPatientsEnvironmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study
Izadi Z, Gianfrancesco M, Schmajuk G, Jacobsohn L, Katz P, Rush S, Ja C, Taylor T, Shidara K, Danila M, Wysham K, Strangfeld A, Mateus E, Hyrich K, Gossec L, Carmona L, Lawson-Tovey S, Kearsley-Fleet L, Schaefer M, Al-Emadi S, Sparks J, Hsu T, Patel N, Wise L, Gilbert E, Duarte-García A, Valenzuela-Almada M, Ugarte-Gil M, Ljung L, Scirè C, Carrara G, Hachulla E, Richez C, Cacoub P, Thomas T, Santos M, Bernardes M, Hasseli R, Regierer A, Schulze-Koops H, Müller-Ladner U, Pons-Estel G, Tanten R, Nieto R, Pisoni C, Tissera Y, Xavier R, Marques C, Pileggi G, Robinson P, Machado P, Sirotich E, Liew J, Hausmann J, Sufka P, Grainger R, Bhana S, Gore-Massy M, Wallace Z, Yazdany J, Registry C, Dahou B, Gómez G, Roberts K, Baez R, Coello V, Salinas M, Maldonado F, Reyes A, Alle G, Tanten R, Ficco H, Nieto R, Gobbi C, Tissera Y, Pisoni C, Paula A, Albiero J, Schmid M, Cosatti M, Gamba M, Leandro C, Cusa M, German N, Bellomio V, Takashima L, Pera M, Cogo K, Elkin M, Medina M, Savio V, Tessel R, Alamino R, Werner M, Ornella S, Casalla L, de la Vega M, Severina M, García M, Lucero L, Romeo C, Moyano S, Barbich T, Bertoli A, Baños A, Petruzzelli S, Matellan C, Conti S, Lazaro M, Gil G, Risueño F, Quaglia M, Scafati J, Cuchiaro N, Rebak J, Pineda S, Calvo M, Picco E, Yanzi J, Maid P, Guaglianone D, Morbiducci J, Porta S, Herscovich N, Zamora J, Kisluk B, Menescardi M, Gallo R, Martire M, Maldini C, Goizueta C, de la Vega Fernandez S, Aeschlimann C, Subils G, Rath E, Piette Y, Devinck M, Maeyaert B, Ribeiro F, Ribeiro S, Pinheiro M, Ibáñez S, Trubert A, Dong L, Cajas L, Barešić M, Anić B, Ćulo M, Pavelić T, Stranski K, Karanovic B, Vencovsky J, Píchová M, Filkova M, Hamoud H, Vassilopoulos D, Melgar G, So H, Király M, Vojdanian, Gurman A, Abutiban F, Zepa J, Bulina I, Bukauskiene L, Montiel B, Ortiz A, Tehozol E, Morales D, Rosete D, Nares E, Reyna T, Gabayet M, Rodríguez D, Irazoque F, Jimenez X, van Bon L, Zijlstra T, Hoekstra M, Al Adhoubi N, Salim B, Giraldo E, Salinas A, Gil M, Nowakowski J, Conway R, Flood R, McCarthy G, Felea I, Filipescu I, Rednic S, Groseanu L, Tamas M, Mlynarikova V, Skamlova M, Zlnay M, Mičeková D, Capova L, Macejova Z, Šteňová E, Raffayova H, Belakova G, Strakova E, Senčarová M, Žlnayová S, Sabová A, Spisakova D, Oetterová M, Lukacova O, Bakosova M, Hocevar A, de la Torre Rubio N, Sancho J, Coro M, Garcia J, Martin M, Campos J, Puerta J, Yardimci G, Akar S, Icacan O, ÇELİK S, Vasylets V, Yeoh S, Vandevelde C, Dunt S, Leeder J, Macphie E, Salerno R, Graver C, Williams K, O'Reilly S, Devine K, Tyler J, Warner E, Pilcher J, Patel S, Nikiphorou E, Chadwick L, Jones C, Harrison B, Thornton L, O'Kane D, Fusi L, Low A, Horton S, Jatwani S, Baig S, Bajwa H, Berglund V, Dahle A, Dorman W, Hargrove J, Hilton M, Lebedoff N, Leonard S, Morgan J, Pfeifer E, Skemp A, Wilson J, Wolff A, Cepeda E, Todd D, Hare D, Calabrese C, Adams C, Khosroshahi A, Kilian A, White D, Winter M, Fields T, Siegel C, Daver N, Harvey M, Kramer N, Lamore C, Hogarty S, Yeter K, Siddique F, Ban B, Tanner T, Ruderman E, Davis W, Quinet R, Scopelitis E, Toribio K, Detiege T, Zakem J, Abbass K, Kepecs G, Miranda L, Guma M, Haikal A, Mody S, Mueller D, Jayatilleke A, Zell J, Bays A, Dao K, Ezzati F, Parks D, Karp D, Quiceno G. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study. The Lancet Rheumatology 2022, 4: e603-e613. PMID: 35909441, PMCID: PMC9313519, DOI: 10.1016/s2665-9913(22)00192-8.Peer-Reviewed Original ResearchRheumatic diseasesCOVID-19 outcomesRisk factorsObservational studyCOVID-19COVID-19-related deathsClinical risk factorsMultivariable logistic regressionCOVID-19 severity levelsIndividual-level risk factorsPrimary endpointMean ageIndependent associationHigher oddsAmerican CollegeLower oddsLogistic regressionHospital bedsMortalityDiseaseSocietal factorsMixed effects modelsDeathRheumatologyAssociationDevelopment of a Prediction Model for COVID‐19 Acute Respiratory Distress Syndrome in Patients With Rheumatic Diseases: Results From the Global Rheumatology Alliance Registry
Izadi Z, Gianfrancesco M, Aguirre A, Strangfeld A, Mateus E, Hyrich K, Gossec L, Carmona L, Lawson‐Tovey S, Kearsley‐Fleet L, Schaefer M, Seet A, Schmajuk G, Jacobsohn L, Katz P, Rush S, Al‐Emadi S, Sparks J, Hsu T, Patel N, Wise L, Gilbert E, Duarte‐García A, Valenzuela‐Almada M, Ugarte‐Gil M, Ribeiro S, de Oliveira Marinho A, de Azevedo Valadares L, Di Giuseppe D, Hasseli R, Richter J, Pfeil A, Schmeiser T, Isnardi C, Torres A, Alle G, Saurit V, Zanetti A, Carrara G, Labreuche J, Barnetche T, Herasse M, Plassart S, Santos M, Rodrigues A, Robinson P, Machado P, Sirotich E, Liew J, Hausmann J, Sufka P, Grainger R, Bhana S, Costello W, Wallace Z, Yazdany J, Registry G. Development of a Prediction Model for COVID‐19 Acute Respiratory Distress Syndrome in Patients With Rheumatic Diseases: Results From the Global Rheumatology Alliance Registry. ACR Open Rheumatology 2022, 4: 872-882. PMID: 35869686, PMCID: PMC9350083, DOI: 10.1002/acr2.11481.Peer-Reviewed Original ResearchAcute respiratory distress syndromeRisk score calculatorCOVID-19 acute respiratory distress syndromeRespiratory distress syndromeScore calculatorCOVID-19 diagnosisDistress syndromeRheumatic diseasesCoronavirus disease 2019 acute respiratory distress syndromeIndependent registriesCOVID-19 disease progressionRegression modelsKey risk factorsRisk stratificationARDS outcomeRisk factorsDisease progressionHighest mean AUCHigh riskPatientsMean AUCClinical settingRegistryMonoclonal antibodiesSyndromeBaseline factors associated with self-reported disease flares following COVID-19 vaccination among adults with systemic rheumatic disease: results from the COVID-19 global rheumatology alliance vaccine survey
Rider L, Parks C, Wilkerson J, Schiffenbauer A, Kwok R, Farhadi P, Nazir S, Ritter R, Sirotich E, Kennedy K, Larche M, Levine M, Sattui S, Liew J, Harrison C, Moni T, Miller A, Putman M, Hausmann J, Simard J, Sparks J, Miller F, Akpabio A, Alpizar-Rodriguez D, Berenbaum F, Bulina I, Conway R, Singh A, Duff E, Durrant K, Gheita T, Hill C, Howard R, Hoyer B, Hsieh E, Kibbi L, Kilian A, Kim A, Liew D, Lo C, Miller B, Mingolla S, Nudel M, Palmerlee C, Singh J, Singh N, Ugarte-Gil M, Wallace J, Young K, Bhana S, Costello W, Grainger R, Machado P, Robinson P, Sufka P, Wallace Z, Yazdany J, Foster G, Thabane L, Angevare S, Beesley R, Chock E, Degirmenci B, Felix C, Jin S, Mateus E, Peirce A, Sari E, Tseng R, Wang L, Zamora E. Baseline factors associated with self-reported disease flares following COVID-19 vaccination among adults with systemic rheumatic disease: results from the COVID-19 global rheumatology alliance vaccine survey. Rheumatology 2022, 61: si143-si150. PMID: 35460240, PMCID: PMC9248066, DOI: 10.1093/rheumatology/keac249.Peer-Reviewed Original ResearchConceptsSystemic rheumatic diseasesCOVID-19 vaccinationRisk factorsDisease flareRheumatic diseasesHigher oddsSARS-CoV-2 severityFlare of diseaseIdiopathic inflammatory myopathiesSystemic lupus erythematosusOxford-AstraZeneca vaccineMultivariable logistic regressionHistory of reactionPotential risk factorsPfizer-BioNTech vaccineLarge international studyImmunosuppressive medicationsInternational studiesVaccines surveyAdverse eventsInflammatory myopathiesPolymyalgia rheumaticaProspective cohortPsoriatic arthritisBaseline factors
2021
Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study
Sattui S, Conway R, Putman M, Seet A, Gianfrancesco M, Beins K, Hill C, Liew D, Mackie S, Mehta P, Neill L, Gomez G, Salinas M, Maldonado F, Mariz H, de Sousa Studart S, Araujo N, Knight A, Rozza D, Quartuccio L, Samson M, Bally S, Maria A, Chazerain P, Hasseli R, Müller-Ladner U, Hoyer B, Voll R, Torres R, Luis M, Ribeirio S, Al-Emadi S, Sparks J, Hsu T, D’Silva K, Patel N, Wise L, Gilbert E, Almada M, Duarte-García A, Ugarte-Gil M, Jacobsohn L, Izadi Z, Strangfeld A, Mateus E, Hyrich K, Gossec L, Carmona L, Lawson-Tovey S, Kearsley-Fleet L, Schaefer M, Sirotich E, Hausmann J, Sufka P, Bhana S, Liew J, Grainger R, Machado P, Wallace Z, Yazdany J, Robinson P, Alliance G, Dahou B, Rath E, Piette Y, Devinck M, Maeyaert B, Ribeiro F, Ribeiro S, Pinheiro M, Quintana R, Gómez G, Roberts K, Baez R, Coello V, Salinas M, Maldonado F, Torres A, Alle G, Tanten R, Ficco H, Nieto R, Gobbi C, Tissera Y, Pisoni C, Paula A, Albiero J, Schmid M, Cosatti M, Gamba M, Leandro C, Cusa M, German N, Bellomio V, Takashima L, Pera M, Cogo K, Elkin M, Medina M, Savio V, Tessel I, Alamino R, Werner M, Ornella S, Casalla L, de la Vega M, Severina M, García M, Lucero L, Romeo C, Moyano S, Barbich T, Bertoli A, Baños A, Petruzzelli S, Matellan C, Conti S, Lazaro M, Gil G, Risueño F, Quaglia M, Scafati J, Cuchiaro N, Rebak J, Pineda S, Calvo M, Picco E, Yanzi J, Maid P, Guaglianone D, Morbiducci J, Porta S, Herscovich N, Zamora J, Kisluk B, Menescardi M, Gallo R, Martire M, Maldini C, Goizueta C, de la Vega Fernandez S, Aeschlimann C, Subils G, Ibáñez S, Chassin-Trubert A, Dong L, Cajas L, Barešic M, Anic B, Culo M, Pavelic T, Stranski K, Karanovic B, Vencovsky J, Píchová M, Filkova M, Hamoud H, Vassilopoulos D, Melgar G, So H, Király M, Vojdanian, Balbir-Gurman A, Abutiban F, Zepa J, Bulina I, Bukauskiene L, Zaueta B, Ortiz A, Tehozol E, Vega D, Rosete D, Nares E, Rodriguez-Reyna T, Gabayet M, Alpízar-Rodríguez D, Irazoque F, Jimenez X, Bon L, Zijlstra T, Hoekstra M, Al-Adhoubi N, Salim B, Giraldo E, Salinas A, Ugarte-Gil M, Nowakowski J, Al-Emadi S, Conway R, Flood R, McCarthy G, Felea I, Filipescu I, Rednic S, Groseanu L, Tamas M, Mlynarikova V, Skamlova M, Zlnay M, Miceková D, Capova L, Macejova Z, Štenová E, Raffayova H, Belakova G, Strakova E, Sencarová M, Žlnayová S, Sabová A, Spisakova D, Oetterová M, Lukacova O, Bakosova M, Hocevar A, de la Torre-Rubio N, Sancho J, Coro M, Garcia J, Martin M, Campos J, Puerta J, Yardimci G, Akar S, Icacan O, Çelik S, Vasylets V, Yeoh S, Vandevelde C, Dunt S, Leeder J, Macphie E, Salerno R, Graver C, Williams K, O'Reilly S, Devine K, Tyler J, Warner E, Pilcher J, Patel S, Nikiphorou E, Chadwick L, Jones C, Harrison B, Thornton L, O'Kane D, Fusi L, Low A, Horton S, Jatwani S, Baig S, Bajwa H, Berglund V, Dahle A, Dorman W, Hargrove J, Hilton M, Lebedoff N, Leonard S, Morgan J, Pfeifer E, Skemp A, Wilson J, Wolff A, Cepeda E, D'Silva K, Hsu T, Patel N, Sparks J, Todd D, Wallace Z, Hare D, Calabrese C, Adams C, Khosroshahi A, Kilian A, White D, Winter M, Fields T, Siegel C, Daver N, Harvey M, Kramer N, Lamore C, Hogarty S, Yeter K, Wise L, Siddique F, Ban B, Tanner T, Ruderman E, Davis W, Quinet R, Scopelitis E, Toribio K, Webb-Detiege T, Zakem J, Abbass K, Kepecs G, Miranda L, Guma M, Haikal A, Mody S, Mueller D, Jayatilleke A, Zell J, Bays A, Dao K, Fatemeh E, Parks D, Karp D, Quiceno G. Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study. The Lancet Rheumatology 2021, 3: e855-e864. PMID: 34778843, PMCID: PMC8570701, DOI: 10.1016/s2665-9913(21)00316-7.Peer-Reviewed Original ResearchPrimary systemic vasculitisCOVID-19 outcomesPoor COVID-19 outcomesNumber of comorbiditiesRetrospective cohort studySystemic vasculitisPolymyalgia rheumaticaSupplemental oxygenDisease activityCohort studyRisk factorsOdds ratioMultivariable ordinal logistic regression analysisSevere COVID-19 outcomesHigh-dose glucocorticoidsLow disease activitySevere disease activityGiant cell arteritisUnmodifiable risk factorsLogistic regression analysisOrdinal logistic regression analysisCOVID-19Eligible patientsGlucocorticoid useMore comorbidities
2020
Management of major bleeds in patients with immune thrombocytopenia
Mithoowani S, Cervi A, Shah N, Ejaz R, Sirotich E, Barty R, Li N, Nazy I, Arnold D. Management of major bleeds in patients with immune thrombocytopenia. Journal Of Thrombosis And Haemostasis 2020, 18: 1783-1790. PMID: 32219982, DOI: 10.1111/jth.14809.Peer-Reviewed Original ResearchConceptsMajor bleedsImmune thrombocytopeniaEmergency departmentITP patientsEvidence-based treatment strategiesIntravenous immune globulinRetrospective cohort studyPermanent neurological disabilityITP therapyMajor bleedingRecurrent bleedsHemodynamic instabilityMinor bleedingCohort studyED visitsGross hematuriaImmune globulinAcute treatmentNeurological disabilityArterial thrombosisPlatelet transfusionsSevere thrombocytopeniaSignificant morbidityMale sexRisk factors