Featured Publications
Definition of a critical bleed in patients with immune thrombocytopenia: Communication from the ISTH SSC Subcommittee on Platelet Immunology
Sirotich E, Guyatt G, Gabe C, Ye Z, Beck C, Breakey V, Cooper N, Cuker A, Charness J, de Wit K, DiRaimo J, Fein S, Grace R, Hassan Z, Jamula E, Kang M, Manski C, O'Connor C, Pai M, Paynter D, Porter S, Pruitt B, Strachan G, Webert K, Yan J, Kelton J, Bakchoul T, Arnold D. Definition of a critical bleed in patients with immune thrombocytopenia: Communication from the ISTH SSC Subcommittee on Platelet Immunology. Journal Of Thrombosis And Haemostasis 2021, 19: 2082-2088. PMID: 34327824, DOI: 10.1111/jth.15368.Peer-Reviewed Original ResearchConceptsImmune thrombocytopeniaSevere thrombocytopeniaGuideline panelCritical anatomical sitesLow platelet countISTH SSC SubcommitteeBleeding eventsMajor bleedsOngoing bleedPlatelet immunologyCompartment syndromeHemodynamic instabilityRespiratory compromisePhysiologic riskPlatelet countAutoimmune diseasesUrgent treatmentPatient representativesAnatomical sitesThrombocytopeniaUpcoming guidelinesPatientsBleedStandardized definitionsClinical expertsPerformance characteristics of platelet autoantibody testing for the diagnosis of immune thrombocytopenia using strict clinical criteria
Gabe C, Sirotich E, Li N, Ivetic N, Nazy I, Smith J, Kelton J, Arnold D. Performance characteristics of platelet autoantibody testing for the diagnosis of immune thrombocytopenia using strict clinical criteria. British Journal Of Haematology 2021, 194: 439-443. PMID: 34109621, DOI: 10.1111/bjh.17566.Peer-Reviewed Original ResearchConceptsPlatelet autoantibody testingImmune thrombocytopeniaAutoantibody testingPlatelet autoantibodiesITP patientsDiagnosis of ITPCertain patient subsetsAnti-glycoprotein IIb/IIIaStrict clinical criteriaHigh pretest probabilityAntigen capture assayIIb/IIIaPatient subsetsClinical criteriaPretest probabilityTreatment responsePatientsHigher optical density valuesOptical density valuesThrombocytopeniaAutoantibodiesCapture assayDiagnosisSpecificityTesting
2024
Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review
Chowdhury S, Sirotich E, Guyatt G, Gill D, Modi D, Venier L, Mahamad S, Chowdhury M, Eisa K, Beck C, Breakey V, de Wit K, Porter S, Webert K, Cuker A, O'Connor C, ‐DiRaimo J, Yan J, Manski C, Kelton J, Kang M, Strachan G, Hassan Z, Pruitt B, Pai M, Grace R, Paynter D, Charness J, Cooper N, Fein S, Agarwal A, Nazaryan H, Siddiqui I, Leong R, Pallapothu S, Wen A, Xu E, Liu B, Shafiee A, Rathod P, Kwon H, Dookie J, Zeraatkar D, Thabane L, Couban R, Arnold D. Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review. European Journal Of Haematology 2024 PMID: 39552264, DOI: 10.1111/ejh.14351.Peer-Reviewed Original ResearchImmune thrombocytopeniaCritical bleedingTPO-RAsPlatelet transfusionsCritically bleeding patientsPlatelet count responseSystematic reviewReview of treatmentBleeding patientsIVIGEvidence-based protocolsBleedingBleeding emergenciesCorticosteroidsSystematic review of treatmentsPatientsSplenectomyPatient outcomesIndividualized treatmentThrombocytopeniaPlateletTransfusionEffects of individual treatmentsTreatmentStudy design
2023
Patient perspectives on telemedicine use in rheumatology during the COVID-19 pandemic: survey results from the COVID-19 Global Rheumatology Alliance
Maheswaranathan M, Miller B, Ung N, Sinha R, Harrison C, Egeli B, Degirmenci H, Sirotich E, Liew J, Grainger R, Chock E. Patient perspectives on telemedicine use in rheumatology during the COVID-19 pandemic: survey results from the COVID-19 Global Rheumatology Alliance. Clinical Rheumatology 2023, 43: 543-552. PMID: 37552351, DOI: 10.1007/s10067-023-06717-2.Peer-Reviewed Original ResearchConceptsRheumatic diseasesPerson visitsTelemedicine useMedication changesCOVID-19 pandemicCare of patientsPerspectives of patientsMethodsAn anonymous online surveyPerspectives of telemedicineDisease activityComplete responseMost patientsPatient's perspectiveTelemedicine effectivenessPatientsAnonymous online surveyFree-text responsesSimilar effectivenessDiseaseVisitsTelemedicine usersRheumatologyYounger participantsTelemedicineClinical tasks
2022
Association Between Race/Ethnicity and COVID‐19 Outcomes in Systemic Lupus Erythematosus Patients From the United States: Data From the COVID‐19 Global Rheumatology Alliance
Ugarte‐Gil M, Alarcón G, Seet A, Izadi Z, Montgomery A, Duarte‐García A, Gilbert E, Valenzuela‐Almada M, Wise L, Sparks J, Hsu T, D'Silva K, Patel N, Sirotich E, Liew J, Hausmann J, Sufka P, Grainger R, Bhana S, Wallace Z, Jacobsohn L, Strangfeld A, Mateus E, Hyrich K, Gossec L, Carmona L, Lawson‐Tovey S, Kearsley‐Fleet L, Schaefer M, Machado P, Robinson P, Gianfrancesco M, Yazdany J. Association Between Race/Ethnicity and COVID‐19 Outcomes in Systemic Lupus Erythematosus Patients From the United States: Data From the COVID‐19 Global Rheumatology Alliance. Arthritis Care & Research 2022, 75: 53-60. PMID: 36239292, PMCID: PMC9874592, DOI: 10.1002/acr.25039.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusCOVID-19 outcomesRace/ethnicitySevere COVID-19 outcomesSystemic lupus erythematosus patientsImmunosuppressive drug useLupus erythematosus patientsCOVID-19 severityUS general populationLogistic regression modelsOrdinal logistic regression modelsGlucocorticoid doseDisease activityPandemic time periodSD ageLupus erythematosusPossible confoundersSevere outcomesMultivariable modelHigher oddsGeneral populationPatientsDrug useHealth disparitiesOutcome categoriesFactors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry
Yeoh S, Gianfrancesco M, Lawson-Tovey S, Hyrich K, Strangfeld A, Gossec L, Carmona L, Mateus E, Schäfer M, Richez C, Hachulla E, Holmqvist M, Scirè C, Lorenz H, Voll R, Hasseli R, Jayatilleke A, Hsu T, D’Silva K, Pimentel-Quiroz V, del Mercado M, Shinjo S, dos Reis Neto E, da Rocha L, de Oliveira e Silva Montandon A, Pons-Estel G, Ornella S, Exeni M, Velozo E, Jordan P, Sirotich E, Hausmann J, Liew J, Jacobsohn L, Gore-Massy M, Sufka P, Grainger R, Bhana S, Wallace Z, Robinson P, Yazdany J, Machado P. Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry. RMD Open 2022, 8: e002508. PMID: 36100295, PMCID: PMC9471207, DOI: 10.1136/rmdopen-2022-002508.Peer-Reviewed Original ResearchConceptsIdiopathic inflammatory myopathiesSevere COVID-19Prednisolone-equivalent doseHigh disease activityDisease activityInflammatory myopathiesMale sexSevere outcomesCOVID-19Multivariable ordinal logistic regressionOlder ageHigher comorbidity burdenLarge registry dataCOVID-19 diagnosisComorbidity burdenRituximab exposureClinical characteristicsRisk stratificationOrdinal logistic regressionRegistry dataHospitalisationSeverity ScaleDemographic dataLogistic regressionPatientsCharacteristics and Outcomes of People With Gout Hospitalized Due to COVID‐19: Data From the COVID‐19 Global Rheumatology Alliance Physician‐Reported Registry
Jatuworapruk K, Montgomery A, Gianfrancesco M, Conway R, Durcan L, Graef E, Jayatilleke A, Keen H, Kilian A, Young K, Carmona L, Cogo A, Duarte‐García A, Gossec L, Hasseli R, Hyrich K, Langlois V, Lawson‐Tovey S, Malcata A, Mateus E, Schafer M, Scirè C, Sigurdardottir V, Sparks J, Strangfeld A, Xavier R, Bhana S, Gore‐Massy M, Hausmann J, Liew J, Sirotich E, Sufka P, Wallace Z, Machado P, Yazdany J, Grainger R, Robinson P. Characteristics and Outcomes of People With Gout Hospitalized Due to COVID‐19: Data From the COVID‐19 Global Rheumatology Alliance Physician‐Reported Registry. ACR Open Rheumatology 2022, 4: 948-953. PMID: 36000538, PMCID: PMC9539246, DOI: 10.1002/acr2.11495.Peer-Reviewed Original ResearchMore comorbiditiesVentilatory supportPoor outcomeCOVID-19COVID-19-related deathsChronic kidney diseasePresence of comorbiditiesCohort of peopleCOVID-19 outcomesCoronavirus disease 2019Outcomes of peopleMedication exposureOverall cohortVentilation supportDiabetes mellitusSupplemental oxygenKidney diseaseMean ageRisk factorsCardiovascular diseaseDisease 2019ComorbiditiesGoutCohortPatientsDevelopment of a Prediction Model for COVID‐19 Acute Respiratory Distress Syndrome in Patients With Rheumatic Diseases: Results From the Global Rheumatology Alliance Registry
Izadi Z, Gianfrancesco M, Aguirre A, Strangfeld A, Mateus E, Hyrich K, Gossec L, Carmona L, Lawson‐Tovey S, Kearsley‐Fleet L, Schaefer M, Seet A, Schmajuk G, Jacobsohn L, Katz P, Rush S, Al‐Emadi S, Sparks J, Hsu T, Patel N, Wise L, Gilbert E, Duarte‐García A, Valenzuela‐Almada M, Ugarte‐Gil M, Ribeiro S, de Oliveira Marinho A, de Azevedo Valadares L, Di Giuseppe D, Hasseli R, Richter J, Pfeil A, Schmeiser T, Isnardi C, Torres A, Alle G, Saurit V, Zanetti A, Carrara G, Labreuche J, Barnetche T, Herasse M, Plassart S, Santos M, Rodrigues A, Robinson P, Machado P, Sirotich E, Liew J, Hausmann J, Sufka P, Grainger R, Bhana S, Costello W, Wallace Z, Yazdany J, Registry G. Development of a Prediction Model for COVID‐19 Acute Respiratory Distress Syndrome in Patients With Rheumatic Diseases: Results From the Global Rheumatology Alliance Registry. ACR Open Rheumatology 2022, 4: 872-882. PMID: 35869686, PMCID: PMC9350083, DOI: 10.1002/acr2.11481.Peer-Reviewed Original ResearchAcute respiratory distress syndromeRisk score calculatorCOVID-19 acute respiratory distress syndromeRespiratory distress syndromeScore calculatorCOVID-19 diagnosisDistress syndromeRheumatic diseasesCoronavirus disease 2019 acute respiratory distress syndromeIndependent registriesCOVID-19 disease progressionRegression modelsKey risk factorsRisk stratificationARDS outcomeRisk factorsDisease progressionHighest mean AUCHigh riskPatientsMean AUCClinical settingRegistryMonoclonal antibodiesSyndrome
2020
Characteristics associated with Covid-19 in patients with Rheumatic Disease in Latin America: data from the Covid-19 Global Rheumatology Alliance physician-reported registry
Ugarte-Gil M, Marques C, Alpizar-Rodriguez D, Pons-Estel G, Xibille-Friedmann D, Paiva E, Zamora-Tehozol E, Gamboa-Cárdenas R, Quintana R, Rodriguez-Reyna T, Sepúlveda A, Gianfrancesco M, Evans M, Wallace Z, Sirotich E, Omedo E, Hausmann J, Alarcón G, Robinson P, Yazdany J. Characteristics associated with Covid-19 in patients with Rheumatic Disease in Latin America: data from the Covid-19 Global Rheumatology Alliance physician-reported registry. Global Rheumatology 2020 DOI: 10.46856/grp.10.e003.Peer-Reviewed Original ResearchOdds ratioRheumatic diseasesConfidence intervalsCharacteristics of patientsSystemic lupus erythematosusMultivariable logistic regressionFrequent rheumatic diseasesCOVID-19 diagnosisVentilatory supportLupus erythematosusRheumatoid arthritisDisease featuresPatientsLogistic regressionCOVID-19T-testMortalityDiseaseGroupErythematosusComorbiditiesHospitalizationArthritisRegistryPhysiciansAirmen and health-care providers’ attitudes toward the use of genomic sequencing in the US Air Force: findings from the MilSeq Project
Pereira S, Hsu R, Islam R, Robinson J, Ramapriyan R, Sirotich E, Maxwell M, Majumder M, Blout C, Christensen K, Mehlman M, Parasidis E, Gardner C, Killian J, De Castro M, Green R, McGuire A. Airmen and health-care providers’ attitudes toward the use of genomic sequencing in the US Air Force: findings from the MilSeq Project. Genetics In Medicine 2020, 22: 2003-2010. PMID: 32807975, PMCID: PMC7710566, DOI: 10.1038/s41436-020-0928-9.Peer-Reviewed Original Research
2017
Longitudinal studies that use data collected as part of usual care risk reporting biased results: a systematic review
Farzanfar D, Abumuamar A, Kim J, Sirotich E, Wang Y, Pullenayegum E. Longitudinal studies that use data collected as part of usual care risk reporting biased results: a systematic review. BMC Medical Research Methodology 2017, 17: 133. PMID: 28877680, PMCID: PMC5588621, DOI: 10.1186/s12874-017-0418-1.Peer-Reviewed Original ResearchConceptsUsual careVisit timeSystematic reviewLongitudinal studyCare risksPart of patientsOutcomes of interestTotal followEmbase databasesNumber of visitsEligible articlesLack of needLack of awarenessPatientsImportant predictorVisitsLack of useCareLower proportionRiskPredictorsReviewMEDLINEFollowStudy